OLI Workshop Master Class

“It is already possible to live to be well over 120 years (…) In my own laboratory at UCLA Medical Center, we have extended the maximum life span of fish by 300 percent.” Maximum Life Span”, NY: W. W. Norton, 1983  by Roy L. Walford, M.D.

Introductory Workshop-Seminar

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Location & Schedule (Next Workshop Pending)

 For all info and in order to register, please email at info@happinenessmedicine.com.

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The Happiness Medicine Institute’s Three Days Master Class Training “Coach” Program on Aging Research, Rejuvenation & Holistic Medicine

This Section is under construction

For Days Two and Three of the Workshop, click here

Coach Certification

To get certified as a Happiness Medicine and Optimal Longevity coach, the workshopee needs to attend  the three days of training and pass a certification test at the end of the Program, after which he or she will get the Institute’s Certificate. This section is pending.

Day One: Introduction to Holistic Rejuvenation Medicine

From Theory to Practical Tools to Reach 120 years in good shape 

A full-day Seminar animated by a French biogerontologist, Professor Joubert

Day One is a general introduction to this Master Class where we cover Theory and Praxis. Once we have the tools to better understand the fundamental mechanisms of  holistic living and aging, we can then delve into some clinical experience,  starting with the first holistic priority which is Holistic Cardiology. Thereafter, we analyse the Gut-Brain axis, (with a special focus on Alzheimer’s Disease and Depression) as well as the gastro-intestinal system, holistic dentistry and the body’s six detoxification pathways in association with brain health enhancement, the endocannabinoid system’s regulation, bio-physics and a few other longevity techniques. Diet being essential, we will examine different nutritional approaches as well as aromatherapy, wine medicine, thermal therapies, microbiota diversity, holistic cancer protocols, circadian biology, restorative sleep and more. To become an effective coach, the workshopee will need to understand Methodology, Medical Law and the inner Saboteur paradox (psycho-neuro-immunology). We will conclude this Day One Seminar with an overview on  supplementation and different Longevity enhancement techniques that target the mitochondria, senescent cells, autophagy, hormonal imbalance, telomerase activation, genes, stem cells regeneration and Lab monitoring and more.

We will also give an update on the latest bio-tech and  innovative research, some of which are in clinical trials.

The workshop’s Presentations are supported with Strong Science

The Workshop’s three Seminars’ content will be supported with strong published peer-reviewed evidence that will be visible either via internet posts, power point and-or video. For an introduction to the subject presented by Professor Joubert, see  video A below. For a general overview on where we are today in terms of innovative Bio-Tech Research and longevity genes, see video D from Professor Sinclair.

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The following Workshop program comes from the Happiness Medicine Institute’s Book on Optimal Longevity

(Working Tool for the Three Days Master Class)

This Section is under construction

To help the workshopees with the assimilation of the Workshop’s content, we are producing scientific data that supports some of  the Workshop’s Recommendations. Most of this information comes from a Longevity Medicine book we are still working  on.

Preliminary Longevity & Mind Enhancement Meditation Exercise

“And the LORD said, My spirit shall not always strive with man, for that he also is flesh: yet his days shall be one hundred and twenty years.” (Genesis 6:3: King James Version)

Researchers at the University of California were the first to show that meditators have significantly higher telomerase activity than non-meditators. More supporting published evidence from the Workshop’s presentation will later corroborate this piece of assertion. Furthermore, the regular practice of specific types of Meditations will simultaneiously signal longevity genes to activate telomerase and sharpen both intuition and focus. As a bonus, intellectual assimilation of the content of this Workshop will be enhanced. We will therefore begin this 8 hours workshop with a guided Meditation practice of 20 minutes or so.

GifYogaBalance

The Magic of Meditation:  From Genomic Expression to JDV Consciousness Activation

In 2011, researchers at Harvard were among the first to demonstrate that just eight weeks of mindfulness meditation training caused significant increase in the thickness of the hippocampus, one of the key brain organs. (Source) In this perspective, the same team of Harvard researchers also found that mindfulness meditation decreases brain cell volume in the amygdala, the part of our brain responsible for fear, anxiety and stress. (Source) These changes matched with the participants’ self-reports of their stress levels, demonstrating how changes in the brain correlate with subjective perception and feelings as well. Since focusing our attention on an object (ex: breath or mantra) is one of the central practices of meditation, it’s no surprise that meditation should help improve our ability to focus and be less susceptible to distractions. (Source) Improved concentration and attention is one of the most well-studied benefits of meditation. This is why it makes sense to start off this Workshop with some mind-blowing meditation which we will teach you.

Session A: Introduction to Holistic Rejuvenation Medicine

“The field of ageing research has been completely transformed in the past decade. . . . When single genes are changed, animals that should be old stay young. In humans, these mutants would be analogous to a ninety year old who looks and feels forty-five. On this basis we begin to think of ageing as a disease that can be cured, or at least postponed. . . . The field of ageing is beginning to explode, because so many are so excited about the prospect of searching for – and finding – the causes of ageing, and maybe even the fountain of youth itself”. (Guarente and Kenyon, Nature, 2000)

For millennia, the aging process has been considered to be uncontrollable, even when the average lifespan did not surpass 40 years, which was just a little over 100 years ago. That changed with Professor Elizabeth Blackburn’s discovery of the telomerase gene. (Source) Furthermore, in the early nineties, research on C. elegans, (a tiny nematode worm) confirmed that a single gene mutation extended its life, and that another mutation blocked that extension. (Source) The idea that age could be tweaked by twiddling a few control genetic switches ignited a research and investment boom. As more geroscientists  got better motivated to attempt to break and hack the Longevity Code, new findings started to reveal key biological clocks that epigenically switched on and off longevity genes.

In this perspective, various clinical interventions did increase the worm’s lifespan by a factor of ten and those of lab mice by a factor of two. (Source) Thereafter, telomeres of skin cells were tweaked to lengthen considerably, thanks to a new Lab procedure fine-tuned by Stanford university School of Medicine scientists, these cells were able to divide up to 40 more times more than untreated cells, which means that human somatic cells have been shown to surpass the Hayflick limit and potentially extend their lifespan 40 times more than before. “Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells”. (Source)

The scientific consensus thus transformed. Aging went from being a God given blessing or Satan’s curse, to an inevitable final stage (Cf  Time cover from 1958: “Growing Old Usefully”), followed by a social issue (Time, 1970: “Growing Old in America: The Unwanted Generation”) to this avoidable “je ne sais quoi” phenomenon (1996: “Forever Young”) that could defer death to 142 years for starts (Cf 2015: Time “This Baby Could Live to Be 142 Years Old”).

However, the excitement was not long lasting, if only because it was discovered not too long ago that telomerase was not the central longevity engine. The Longevity Code cook-book is far more complex for mammals and even more so for humans than for a C. Elegans worm, fly, mouse or even the bat (who has an exceptionally long lifespan). Hence, the presentor’s scientific attitude is to prefer the known fundamentals that work to at least 122 years of age while being open to and expecting the best of bio-tech longevity engineering stratagems, many of which are still in the early phases of clinical trials and concomitant marketing schemes.

As we will see, notwithstanding the total and irresponsible lack of drug-supplement interactions, there are many dozens of ongoing drugs and supplements that are already being used in today’s anti-aging and baby-boomer communities, from telomerase activators and senescent cell removal, (senolytics) to autophagy inducers, caloric restriction mimickers, blood donor plasma transfer, nano-robots, mTOR drugs like rapamycin, gene editing, stem cell cyro-preservation, sirtuin-activating molecules, insulin-modulating drugs like  metformin and more. Some of these products are still under investigation in different clinical trials. Not only it can take many years for many of these anti-aging human trials to be completed, but thereafter, many of these anti-aging products will be too expensive for the general public and many of these products are not immune from deleterious side effects. As a consequence, risks may outweigh benefits, especially for people who are relatively healthy and are just seeking to add 30 or 40 extra years to their lifespan. Thus, waiting a few years before some of these bio-tech longevity hacks may be accessible and proven safe and effective is not cellularly or financially responsible, if only because today we have the knowledge that key holistic tools can significantly help to rejuvenate, repair and restore most metabolically impaired tissues. Holistic and Happiness medicine can also meaningfully help to offset and significantly delay Evolution’s programmed aging process.

Distinction between Accelerated and Delayed Aging

For the Happiness Medicine Team, there is no question that aging is less an irreversible metabolic process of accumulated damage and systemic debilitation than a genetic and evolutionary-based “mise à mort” (death process) program that is plastic, meaning modifiable. The evidence does confirm that once we have self-replicated to both share and pass on our genes for the benefit of Community, Nature or Evolution puts in place via specific genetic expression signals a program to destroy fertility, stamina and a healthy long lifespan, especially for those who choose to live unholistically. As a result, signaling molecules that broadcast  identifiable instructions inundate the  bloodstream to accelerate inflammation, in particular via the Cox2 and NF-Tb pathways, the growth of debilitating senescent cells, oxidative stress and, among others, cancer. Concomitantly, youthful hormones, repair mechanisms, small RNAsmicro-proteins and the like are decelerated. While the anti-aging industry strives to attempt to fix these problems with gene therapy and symptom-targeting drugs and supplements, we at the Happiness Medicine Institute show that both preventive care and holistic savoir-faire can promote enough homeostasis and rejuvenation for most humans to be able to reprogram and-or fine-tune the mainstream Genetic Code so that genetic expression de-activates the chronic disease genes and pathways while upregulating the healthy and longevity ones. Until proof of the contrary, all living forms eventually die, including the great tortoises and the small naked mole rats. Humans are no exception. Different from certain species of tortoises who live over 200 years, the more women age, the less fertile they become (for a species of tortoise, with age there are more & more eggs). But what most biogerontologists miss and even dismiss is happiness and holistic medicine as a meaningful vector of rejuvenation in terms of reversing the mainstream accelerated aging culture (code) to one that is characterized by a smooth healthy delayed aging process, based on holistic savoir-faire and abundance, including an abundance of simplicity, consciousness and digestive rest. Just like with conventional medicine, too many gerontologists are focused on a symptom-based approach to aging, treating one damaged organ at a time without a holistic approach. By a holistic approach, we don’t only mean a root-cause lab-test analysis of a chronic disease. Often, an oxytocin-abundant hug, an extra pay check bonus or a clear-conscious spiritual awakening will have an “anti-age” effect that is clinically superior to a sirtuin or synolitic pill. In this context, the zip code (where and with whom a person lives) can therefore “over-ride” the genetic code.

The Happiness Medicine and O.L. Institutes’ central Premise on Aging and Longevity

When young, the body is flexible, strong, fertile and repairs quickly damage. When older, the body gradually destroys itself with inflammation, eliminating nerve and muscle cells via apoptosis and more. Today, we can identify a few mechanisms of action that promote these two evolutionary states of being, one of which are circulating hormonal signals that travel in the blood’s plasma. When hormones and other blood factors emit the message “old, your self-replication time is up” we get older and vice versa. This basic premise rests on a hypothesis that has been empirically tested with success, as we will see during the development of this workshop. As a consequence, happiness and holistic medicine may be the best ever health approach to gently upregulate the youthful signals and staunchly downregulate the disease and accelerated death instructions we have allowed to be part of human Consciousness’ genetic program.

Exhibit A

Video Excerpt on a 2016  Optimal Longevity Medicine Lecture from Professor Joubert (Optimal Longevity Institute)

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The Basics of Biogerontology

“The idea is to die young as late as possible.” (Ashley Montagu)

After a brief introduction, the workshopees will be introduced to the evidence that corroborates the reality of healthy long human lifespans (in between 110 and 122 years of age). In this  context, we will examine supercentenarian individuals like Jeanne Calment (who reached 122 years), the longevity valleys and blue zones as well as the scientific debates regarding maximum human lifespans. These analyses will help us to identify the key longevity factors that characterize some of these geographical areas where healthy centenarians are abundant. Thereafter, we will examine the aging and longevity biomarkers as well as the  major hallmarks or biochemical pathways of aging.

Nobel Professors of Physiology whose recent findings have meaningfully enhanced the value of Rejuvenation Medicine

In this Presentation, we will review a few Nobel laureates who have greatly contributed to the understanding of the Longevity Code, from a Japanese Professor’s work on autophagy (for which he received a Nobel prize in 2016) (Source) as well as from recent discoveries regarding a Circadian clock that governs much of mammalian biology, (Source), Professor Blackburns’ discoveries on Telomerase as well as Yamanaka and John Gurdon efforts, who were awarded the Nobel Prize for Physiology in 2012 for the discovery that mature cells can be converted back in time to stem cells. (Source) Professor Horvath, who fined-tuned another biological clock called the Epigenetic clock has also helped to redirect biogerontology to one of the key hallmarks of aging, the epigenome, as well as a few other Nobel laureates.

Biomarkers (Aging and Longevity)

During the last few years, multiple efforts have been made to better quantify biological aging. One of the first  institutes to work on this project are the National Aging Institute (cf. the Baltimore Longitudinal Study of Aging (BLSA)) and the N.I.H’s Nhanes  survey. (Source). The European MARK-AGE brought together over 20 European countries to also contribure in this endeavor, while a group of scientists in New Zealand recently looked at 18 aging biomarkers in a cohort of young adults that were followed for 12 years. This New Zealand study, called the “Dunedin Study”, suggests that rates of aging can be measured even in relatively young adults.  (Cf. Daniel W. Belsky et al., Quantification of biological aging in young adults, PNAS, Jul 2015, 112 (30) E4104-E4110).

Once we have reviewed most of the significant physical, biological and genetical (DNA) biomarkers that have been worked on, we will select the most relelvant biomarkers that appear to be the best suited to assess at any given moment a person’s biological age as well as his or her  healthy lifespans predictors. These evaluations can also help to better address age-related diseases and one’s optimal longevity potential. One of the impotant challenges for future clinicians will be to integrate these aging and longevity biomarkers  with the  physiological and biochemical markers that are already in use in medicine.

The Epigenetic Clock

Of all of the biological clocks (telomere clock, circadian clock, hypothalamus clock etc) that can be biomarkers of aging, the Epigenetic Clock is one of the more reliable ones, recently considered by the biogerontology experts to be even more reliable than the Telomerase Shortening clock. Based on DNA methylation, histone modification and other factors, this “senescence-measuring” clock had been determined to be 98 percent accurate. (Source) Over 300 methylation sites have been correlated with biological age. Professor Steve Horvath, a biostatistician from UCLA, published a key article  in which he analyzed the way gene expression changes with age. A semi-permanent factor in gene expression is methylation of the DNA, and Horvath showed that a person’s age can be determined by using a statistical template he developed to analyze which genes are methylated. UCLA professors are still working on this clock’s fine-tuning. (Source) Once this tool gets perfected and becomes better recognized, it may be a great way to monitor rejuvenation techniques, whether this supplement or that lifestyle change or drug does in fact slow or stop the biologically “programed” organismal senescence process. In this Presentation, we will show the evidence supporting this claim. To know if such and such a longevity measure is working, we would normally need many years of clinical trial experimentation to ascertain the safety and efficicacy of longevity tools.  However, with dependable biomarkers, health professionals can better monitor progress at a quicker pace, a bit like with cancer biomarkers. From the holistic viewpoint, the use of guided intuition to determine the best personalized pathway to optimal longevity is still an option. But because so many people are out of synch with their intuition, tools like this epigenetic clock and other biomarkers can be useful.

Case studies of a few Humans and Animals who have significantly outlived their peers

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Top: The French Mediterranean dancer, who is the Happiness Medicine Institute’s Hero,  Madame Jeanne Calment, a Piscean born on February 21, 1875,  is still  the  Optimal Longevity Champion. Having reached 122.5 years, according to her claims,  she “allowed” herself to die. In other words, she could have continued to live. Her age was confirmed via birth certificate and the Guiness Record scientist-investigators confirmed this fact. In this picture, she was 120.

In this Presentation, we will study the Life and thoughts of the Mediterranean Extreme Longevity Champion Jeanne Calment whose longevity record has never been broken. (Source) We will also look at her lifestyle, her diet and her medical records that span from 111 years to 118. Thereafter, we will make an evidence-based determination as to what kept her going for over 122 years. A few other super centenarians as well as animals will be compared to this all time longevity record breaker. And yes, she drank red wine with her Med-diet meals, (with, on occasion A2 quality cheese & wild fish), had a great sense of humor and enjoyed lots of dark chocolate, up to one kilo a week (2.2. pounds). (Source) But according to Jeanne herself, French scientists and her doctor, her healthy lifespan secret was something else.

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Are there genetic variants or determinants that account for extreme longevity in humans ?

“Centenarians are the best example of extreme human longevity, and they represent a selected population in which the appearance of major age-related diseases, such as cancer, and cardiovascular diseases among others, has been consistently delayed or escaped. The study of the long-lived individual genetic profile has the purpose to possibly identify the genes and the allelic variations influencing extended life expectancy, hence considering them as biomarkers of age-related diseases onset and development. The present study shows no significant differences between allelic variations of ABO blood groups among a group of centenarians from Western Sicily”. (Source)
Longevity scientists have been researching “protective longevity genes” for a long time. Some of these “life extension” genes function via cellular defense compensatory mechanisms, in particular with regard to oxidative stress, autophagy and inflammation. In this field, we will look at three of the more important families of genes that modulate age-related pathways. These  are the SIRTUINS, APOEs and FOXOs (FOXO1 and FOXO3) (Cf. Willcox et al., 2006 and Soerensen et al., 2010, 2015 and Brooks‐Wilson, 2013). The variant FOXO3A  for example, is found in many German centenarians as well as in a few other ethnic groups around the world, (Source). On the other hand, FOXO4 has a role in maintaining the harmful state of cellular senescence by sabotaging that specific mechanism that has been shown to selectively push senescent cells into self destruction. So not all FOXO variants have been created equal. On the other hand, the sirtuin genes modulate noly only anti-aging pathways, but also helps with chronic diseases. (Source) And wine’s resveratrol is a sirtuin 1 activator. While APOE4 is problematic, its variant (allele) APOE2 is anti-aging. (Source)In this Presentation, we will briefly assess what is the relevance of longevity genes in relation to stochastic, environmental and epigentic factors upon which humans have control. Later on in the workshop, we will give a list of foods and supplements that can help to activate these and other longevity genes whose ribosomes produce proteins that have beneficial effects on multiple longevity pathways. (See ultra). What is important to underline at this juncture is that genes are downstream to what is quintessential: lifestyle, metabolic processes and holistic tweaking. Just like with cancer. To resolve the cancer challenge, we must focus upstream from genes. Same approach with longevity. We need to focus upstream from longevity and anti-longevity genes. Hence, the importance of rejuvenation and restorative therapies that address the root causes of aging. And by ricochet, this holistic approach helps to express (activate) the good genes and down regulate (de-activate) the harmful accelerated death genes. But before we examine these techniques, we need to better undersand the major hallmarks of biological aging.

Session B. The Biology of Aging: Understanding the Mechanisms that Spur Accelerated & Delayed Aging

“Medicine is not only a science; it is also an art. It does not consist of compounding pills and plasters; it deals with the very processes of life, which must be understood before they may be guided.” Paracelsus

To be motivated to adopt a Holistic Restorative and Rejuvenation Lifestyle, it is first necessary to understand the mechanisms that govern normal aging in relation to accelerated aging and slow holistic “delayed” aging. When we see that Lifestyle and holistic savoir-faire impact all of the major hallmarks of aging, including gene expression, it is then easier to pay attention to what is important in Life, provided one desires a healthy supercentenarian existence. But one must genuinely and vividly desire to achieve this Life potential. The supercentenarian life is not for the faint of heart. To achieve this high vibrational level of Life, resistance against toxicity and activation of holistic techniques, including in the fields of relaxation, detox, exercises, meditation, up-beat attitude, hormesis, quality nutrition, sleep and vibrant water intake, among other elements,  are more important than the genetic or zip codes.

What is Biological Aging & Senescence ?

“ ..aging can be modulated by genetic pathways and biochemical processes which are evolutionarily conserved” (Lopez‐Otin et al., 2013))

Mainstream conventional non-holistic biological aging (or senescence) is characterized by a progressive loss of physiological integrity, leading to impaired function, accumulated damage, rampant frailty, complete infertility and death in an expensive hospital bed, usually after a hefty morphine drip hook-up, but a little before the morgue industry arrives. I’ve also heard some gerontolists say that aging is the declining ability to respond to stress characterized by increased homeostatic imbalances and functional degradation occurring in a stochastic (random) fashion that leads to the accumulation of cellular damage, tissue decline and death (i.e., cerebral hypoxia, i.e., lack of oxygen to the brain, is the immediate cause of all human deaths).

On the other hand, there’s the holistic way to age, where the death candidate thrives until the last weeks and thereafter, leaves his or her body in his or her sleep and-or with full consciousness on the terrain with little if any painful experience.

Because the structural bio-chemical and genetic causes of aging and chronic diseases share similar pathways and since we can control and reverse most chronic diseases with holistic and innovative medicine, it necessarily follows that aging can be less a business than a  ritual celebrating the ending or crowning of a human life at it’s full potential, for now at 122 years.

Cellular and Organismal Senescence is not shared by all Living Beings

Senescence is not the inevitable fate of all living organisms. The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats and the existence of species that have negligible senescence and even no biological aging have been documented for a long time.

A careful examination of the data shows that Life, of which humans are part, exudes multiple forms that experience very slow or no biological aging. Indeed, different living organisms who share the same genes as humans experience chronological decrease in mortality, for all or part of their life cycle  (Cf. Ainsworth, C; Lepage, M (2007). “Evolution’s greatest mistakes”. New Scientist. 195 (2616): 36–39 Source). Species like the Hydra are quasi immortal while other species become more fertile with chronological age, like large turtles. The rock fish, like his lobster cousin can live for hundreds of years if it were not for predators and human toxic dumps. Some even exhibit negligible and even negative senescence, in which mortality falls with age, in disagreement with the Gompertz–Makeham “law” which provides that mortality rates accelerate exponentially with age.

Let us consider the Hydra. Today, the best natural scientists have not refuted that Hydra stem cells have a capacity for indefinite self-renewal. The transcription factor, forkhead box O” (FoxO) has been identified as a critical driver of the continuous self-renewal of Hydra. (Boehm, Khalturin, Anton-Erxleben, Hemmrich, Klostermeier, Lopez-Quintero, Oberg, Puchert, Rosenstiel, Wittlieb, Bosch; Khalturin; Anton-Erxleben; Hemmrich; Klostermeier; Lopez-Quintero; Oberg; Puchert; Rosenstiel; Wittlieb; Bosch (2012). “FoxO is a critical regulator of stem cell maintenance in immortal Hydra“. Proceedings of the National Academy of Sciences. 109 (48): 19697. (Source)

Other living organisms like planarian flatworms, and certain sponges, corals, and jellyfish do not die of old age and exhibit potential immortality. (Petralia, Ronald S.; Mattson, Mark P.; Yao, Pamela J. (2014). “Aging and longevity in the simplest animals and the quest for immortality”Ageing Res Rev. 16: 66–82. (Source).

Jellyfish are also known to defy time. The jellyfish known as Turritopsis doohmii, or more commonly, the immortal jellyfish bypasses death by actually reversing its aging process. If the jellyfish is injured or sick, it returns to its polyp stage over a three-day period, transforming its cells into a younger state that will eventually grow into adulthood all over again. (Source) Flatworms are also known for the biological “immortality”.  Also called planarian worms, they are  famous for their regeneration abilities. Even with a severed body, they will grow it back pronto.(Source) Then we have the Deinococcus radiodurans, a poly-extremophilic bacterium who is radiation-resistant. These immortal animals can also die and come back to life thanks to their  DNA repair mechanism. According to Ira S. Pastor,  “[They] can survive cold, dehydration, vacuum, and acid, and [have] been listed as the world’s toughest bacterium.”The Guinness Book of Records states that they “can resist 1.5 million rads of gamma radiation, about 3,000 times the amount that would kill a human”. As for the tardigrade, these creatures are capable of sticking around for thousands of years or even indefinitely “by entering a state of cryptobiosis, whereby their metabolism comes to a halt.” (Source).

Different Theories of Biological Aging

There are multiple theories as to why senescence occurs. Some groups of scientists posit it is programmed by gene expression changes, others that it is the cumulative damage caused by biological processes liked to mitochondrial dysfunction, ROS accumulation, cellular senescence and the P53  while still others believe that cellular senescence is the result of the body’s exhaustion of stem and repair cells in association with telomere attrition etcetera.

While there are many incertitudes in this field, what appears to be irrefutable is that the “terrain”, the “field”, the “milieu” tends to prevail over the “unit”, Life forms. For example, the same stem cells placed in three different petri dishes with a different milieu (terrain) will differentiate differently. Likewise, identical cells (like human twins) that are genetically identical, but have substantially different outside stimuli (bioterrains) will respond differently and hence have different lifespans. These facts indicate that the “terrain”, the “milieu”, the epigenetic factors play a key role in gene expression. (Ryley J; Pereira-Smith OM (2006). “Microfluidics device for single cell gene expression analysis in Saccharomyces cerevisiae”. Yeast. 23 (14–15): 1065–73. (Source)).

Cancer cells & Supercentenarians: Common threads

The current status of aging research exhibits many parallels with that of cancer research. The cancer field gained major momentum in 2000 with the publication of a landmark paper that enumerated six hallmarks of cancer (Hanahan and Weinberg, 2000), and that has been recently expanded to ten hallmarks (Hanahan and Weinberg, 2011). This categorization has helped to conceptualize the essence of cancer and its underlying mechanisms upon which good medicine can intervene.

In this perspective, the condition of cancer and aging may seem opposite processes, but in reality, they share common origins and pathways. What unites both these phenomena is the time-dependent accumulation of cellular DNA damage, which is a major hallmark of both aging and cancer. Therefore, cancer and aging can be regarded as two different manifestations of the same underlying process, namely, the accumulation of cellular damage and genomic instability. In addition, several of the pathologies associated with aging, such as atherosclerosis and inflammation, involve uncontrolled cellular overgrowth (Blagosklonny, 2008).

Furthermore, cancer and supercentenarians share a common “ally”, the telomerase enzyme. By activating its telomerase enzyme to keep telomeres long, over 90 percent of cancer cells have learnt, to become quasi-immortal. As long as they have fuel, cancer cells  continuously divide thanks to the self-replicating telomerase enzyme, hence they are not subject to the Hayflick limit (50 to 70 cell divisions) or the laws of senescence death. (Source). As a result, they don’t age. Similarly, those supercentenarians who reach long lifespans also have more active telomerase and longer telomeres, while children who age very quickly (like this proragia girl in the picture below) have very short telomeres.

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Top: A young infant girl who suffers from  Proregia syndrome. She is only around 2 years old, but appears much more. Also known as Hutchinson-Gilford syndrome, this disease is  genetic. It is characterized by accelerated aging that is accompanied with the age-related diseases.  The mean age at death of these patients is 12.5 years. These children die “old” before 15 or 20, at which point they look like 80 years old.

Case study A: Ultra rapid metabolic accelerating-aging

To better understand a few of the mechanisms behind normal and delayed aging, it’s useful to study cases where aging proceeds very fast and very slow. In humans, there’s a genetic disease called Proregia syndrome, also known as Cockayne syndrome (CS), Hutchinson-Gilford syndrome , Werner’s syndrome (WS), Bloom’s syndrome and trichothiodystrophy. All of these diseases are  autosomal recessive disorders with progeroid symptoms. These disorders are rare genetic diseases characterized with extreme premature aging and a shortened life expectancy. All of the hallmarks of aging are manifested, including cessation of growth, liver, kidney and bone abnormalities, retinopathy, hearing loss, sarcopenia, neurodegeneration, sensitivity to UV light, and a premature aged appearance due to kyphosis, baldness, loss of subcutaneous fat, and, inter alia, dry wrinkled skin. (Source)

Children with progeria have a mutation on the gene that encodes for lamin A, a protein that holds the nucleus of the cell together. This protein is also known as progerin. The defective protein makes the nucleus unstable and short-lived. (Source)  The mean age at death of these patients is 12.5 years. (ibid) There is currently no treatment for these syndromes and the clinical management of patients is essentially palliative. Although some differences exist in the pathology of these conditions, the central causal factor of all these syndromes lies in impaired genome maintenance due to DNA repair deficiencies and genome instability. (Source). Two other hallmarks of aging, the depletion of stem cells as well as telomeres attrition, have also been identified to correlate with this disease.

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Top: A 16 years old little girl who stopped growing at 11 months.

Case Study B: Ultra-slow Growth: Children who do not Age, genetically “frozen” in Time

In contradistinction to children who senesce fast, there are other children who don’t senesce at all or extremely slowly. They also eventually die young,  from complications. The understanding of this medical phenomenon is recent, it started only in 2009 with the report about 16-year-old girl who seemed to be “frozen in time.” She was the size of an infant, with the mental capacity of a toddler rather than a teenager. (Source) See also Brown, Bob (23 June 2006). “Doctors Baffled, Intrigued by Girl Who Doesn’t Age”HealthABC News.

This genetic disease used to be called Syndrome X, but now it is labeled as “neotenic complex syndrome” (NCS). After having sequenced the genome of a few of these diseased children, the researchers found key de novo mutations (DNMs) in two development genes ((DDX3X and HDAC8), located on the X chromosome and affecting transcription regulation and chromatin modification, inter alia. (Source). See also Walker, R.; Pakula, L.; Sutcliffe, M.; Kruk, P.; Graakjaer, J.; Shay, J. (2009). “A case study of “disorganized development” and its possible relevance to genetic determinants of aging”. Mechanisms of ageing and development. 130 (5): 350–356. (Source))

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Roundworms Experimentations confirm: aging and lifespan is regulated in part through the insulin/IGF-1 and mTOR pathways.

Top: the  transparent nematodeC. elegans.This roundworm is one of the most studied for neurodegeneration and longevity. Scientists have been able to significantly extend its lifespans by tweaking its genes. 

In order to study key age-related genes, gerontology specialists examine many different types of genes that come from different animals. According to the GenAge database of aging-related genes, there are over 1800 genes altering lifespan in model organisms: 838 in the soil roundworm (Caenorhabditis elegans), 883 in the bakers’ yeast (Saccharomyces cerevisiae), 170 in the fruit fly (Drosophila melanogaster) and 126 in the mouse (Mus musculus). (Source).

The first mutation found to increase longevity in an animal was the age-1 gene in Caenorhabditis elegans. (Top Picture) Michael Klass discovered that lifespan of C. elegans could be altered by genetic tweaking (mutations), but Klass believed that the effect was due above all to the reduced food consumption (calorie restriction) regime the Elegans worm was put under. He published his results in 1983. (Source). Thomas Johnson later showed that life extension of up to 65% was due to the mutation in gene age-1 itself rather than due to calorie restriction. The age-1 gene encodes the catalytic subunit of class-I phosphatidylinositol 3-kinase (PI3K). (Source)

A decade after Johnson’s discovery, one of the two genes that are essential for dauer larva formation, the “daf-2”, once mutated, was shown by Cynthia Kenyon to double C. elegans lifespan. Nature. 366 (6454): 461–464 (Cf, Dorman, Jennie B.; Albinder, Bella; Shroyer, Terry; Kenyon, Cynthia (1995). See also “The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans”. Genetics. 141 (4): 1399–1406). See (Source).

The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. (Source). DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. (Source). Subsequent genetic modification (PI3K-null mutation) to C. elegans was shown to extend maximum life span tenfold. (Source) See also Shmookler Reis RJ, Bharill P, Tazearslan C, Ayyadevara S (2009). “Extreme-longevity mutations orchestrate silencing of multiple signaling pathways”. Biochimica et Biophysica Acta. 1790 (10): 1075–1083. (Source)

The IGF-1 & mTOR pathways

Research into the interaction between diet and the insulin/IGF-1 pathway has shown sugar intake to be negatively correlated with DAF-16 activity and longevity. In this perspective, Wild type C. elegans was fed a diet that included 2% glucose. It was subsequently shown that Daf-16 activity was reduced and lifespan was shortened by 20% compared to worms fed on glucose-free media. These findings raise the possibility that a low-sugar diet might have beneficial effects on life span in higher organisms. (Lee, S. J.; Murphy, C. T.; Keyon, C. (2009). “Glucose shortens the life span of c. elegans by downregulating daf-16/foxo activity and aquaporin gene expression”Cell Metabolism. 10 (5): 379–391. (Source)).

Many studies in yeast, and in a wide range of multicellular lower and higher organisms, have shown that caloric restriction (CR) simultaneously increases lifespan while improving mitochondrial activity while the inhibition of nutrient sensing (NS)  signaling pathways, such as the Insulin/IGF-1 (Source) and mechanistic target of rapamycin (mTOR) (Source)  pathways, led to similar results.

Several metabolic pathways and molecules regulate lifespan in response to nutrient availability and balance energy expenditure with mitochondrial function. The insulin and IGF1 pathway was the first evolutionarily conserved pathway shown to regulate lifespan. Mammalian target of rapamycin (mTOR) signalling has also been implicated (Source ASource B). There is increasing recognition that these metabolic pathways are intimately interconnected. For instance, AMP-activated protein kinase (AMPK), which is a central sensor of energy homeostasis that modulates mTOR signalling, activates forkhead box O (FOXO) transcription factors, which are targets of insulin and IGF1 signalling. This increases the expression of genes that are involved in stress resistance and energy balance (Source). Decreased activity of the insulin and IGF1 pathway is associated with improved mitochondrial function, as demonstrated in long-lived Ames mice (which have very low levels of IGF1) and in mice with decreased levels of insulin receptor substrate 2 (IRS2) (Source) Reduced insulin and IGF1 signalling results in the activation of FOXO transcription factors, which induce the expression of antioxidants, such as manganese superoxide dismutase (MnSOD) and catalase; accordingly, FOXO-deficient mice display increased levels of ROS and stem cell depletion (Source A,Source B). The 20 percent shortening of the C Elegans’ lifespan with 2 percent glucose in the diet observation only suggests that sugar may be a problem with regard to longevity optimization. The worm was not fed human complex carbs, let alone organic fresh complex carbs, furthermore, healthy carbs for humans may fuel longevity pathways instead of a shortening lifespan because sugar is different from healthy carbs and mammals like humans are different from worms, even if we share common genes, biochemical pathways and wiggly manners. At this juncture, what the facts appear to be suggesting is that in higher organisms, aging is likely to be regulated in part through the insulin/IGF-1 and mTOR pathways.

In Search for a Working Hypothesis of the Key mechanism(s) of Aging

Since the discoveries invoked above, the interest in the molecular pathways that control aging has exploded. In this perspective, many mutations in metabolic pathways have been shown to affect lifespan in different model systems, ranging from yeast to mice. Studies suggest that new pathways are even more relevant for human lifespan than the insulin-IGF-1 and mTOR nutrient sensing ones. Among others, maintenance of mitochondrial function has been suggested to be a key mechanism of extending lifespan, as decreased mitochondrial function, impaired ATP generation and increased reactive oxygen species (ROS) levels have all been shown to be implicated in driving the aging process. Even though mitochondrial homeostasis impairment is clearly associated with aging, the high complexity of aging phenotypes, and their underlying molecular mechanisms, make the deciphering of the real causing elements nonetheless difficult. Moreover, the discovery of mitohormesis in stress response and ROS signaling pathways modified the meaning of mitochondrial oxidative stress. Indeed, as described above, increased ROS and less active mitochondria has been shown to also promote healthy aging and long lifespans. (Source) Likewise with telomerase enhancement, the epigenetic pathways, mTOR inhibition and other pathways. In order to hone in on a core mechanism hypothesis then, we should first better examine what the major molecular mechanisms that are responsible for the aging process are.

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The Major Molecular Mechanisms that best Explain the Aging Process

In this Presentation, we will identify and categorize the recognized cellular and molecular hallmarks (ie, the major mechanisms of action) that govern the process of aging.

There are nine major hallmarks: genomic instability, mitochondrial dysfunction, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication. There is a general consensus in the biogerontoloty community that these hallmarks are the most significant ones insofar as the process of aging is concerned. To these hallmarks, the Happiness Medicine Institute will add a few others.

Ideally, each hallmark should  fulfill the following five criteria: (a) it should manifest during normal aging; (b) its experimental worsening should accelerate the aging process and (c) its experimental improvement should delay the normal aging process in a meaningful way, (d) any  or all illnesses and chronic diseases that accompany those who are experimenting favorably with the targeted hallmark should attenuate if not reverse. Given the holistic principle of inter-connectedness, activating the Life-enhancing elements of one Hallmark should also activate other Hallmarks in a way that restores homeostasis via identifiable compensatory mechanisms. This Presentation will thus look at the major macro-mechanisms or hallmarks that characterize the evolutionary-sculpted aging cascade and whose control and fine-tuning promote healthy lifespans.

The Nine Central Hallmarks of Aging

The scientific community on biogerontology and geroscience is more or less in unison with the following hallmarks of aging that are briefly described below and which will be better developed during the power point presentation. They were summed up and developed in an article written by Carlos Lopez-Otin et al and published in the peer reviwed Journal “Cell” in 2013  (The hallmarks of aging, Cell, June 2013, 153 (6); 1194-1217). However, not all scientists  agree on all of the causes that explain these nine hallmarks of aging, and in particular, the hierarchy of causation (which causes are the most important)..

1. Genomic instability.

Genome instability is defined as  higher than normal rates of DNA mutation. Mutation is not necessarily bad, but under the circumstances of today, it is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution.  But as we see today, genomic instability has catastrophic consequences for age-related diseases such as cancer and other chronic diseases as well as accelerated aging.

In terms of causation, mutations arise either from the  molecular inactivation of DNA repair pathways or as a result of an overload of genotoxic stress from cellular processes such as transcription and replication that overwhelm high-fidelity DNA repair. As we will see in the power point presentation, exposure to external genotoxic agents (pollution) is a huge driver to genomic instability. (Annu Rev Genet. 2013;47:1-32. Source)

2. Mitochondrial DNA Break-down & Dysfunction

Mitochondrial function has a profound impact on the aging process. As cells and organisms age under non holistic conditions, the efficacy of the respiratory chain tends to greatly diminish, thus increasing electron leakage and reducing ATP generation. This mitochondrial decline is especially noticeable in tissues with high energy demand such as the heart and the brain.  In this context, mutations and deletions in aged mtDNA contributes all the more to aging that the oxidative microenvironment of the mitochondria lacks protective histones in the mtDNA. (Human mitochondrial DNA (mtDNA) is a double-stranded, circular molecule of 16,569 bp and contains 3 genes encoding 13 proteins, 22 tRNAs, and 2 rRNAs. Recent mitochondrial transcriptome analyses revealed the existence of small RNAs derived from mtDNA). Likewise with the gradual erosion of the mtDNA repair mechanisms.

In eukaryotic (human) cells, most of the genetic material is nuclear, stored in the nucleus of the cell, where it is strongly protected. On the other hand, the genetic material within these bacteria-derived mitochondria is less protected. Hence, their significant contribution to both chronic diseases and accelerated aging. The loss of AMPK expression as well as Telomere Length and TERT (telomerase) loss have also been associated with mitochondrial biogenesis dysfunction.   (Source)

3. Telomere Shortening and Telomerase Depletion

Normal aging is accompanied by telomere attrition in mammals. Which means, the more somatic cells divide, the less long are telomeres. Once this cellular division reaches what is called the Hayflick peak or limit, they go into Sencescence. Molecularly, telomeres are short sequences of nucleotide repeats found at both ends of each chromosomes. Telomere length shortens with each cell division, which contributes  to the normal process of cellular aging and sets an upper limit on cell lifetimes.

Telomeres provide genomic stability to normal cells and act as a tumor suppression mechanism. (Source). Telomere shortening takes place faster in animals that age faster than those that age slowly. Likewise with Proregia children where pathological telomere dysfunction dramatically accelerates their aging. On the other hand, the experimental stimulation of telomerase delays aging in both mice as well as in human cells in vitro. In Longevity medicine, the more one’s telomeres are maintained in good shape, in general, the longer he or she can extend lifespan. However, there are a few new findings that redefine the longevity implications of telomerase. In this Presentation, we will review telomere biology and where we are at in terms of whether or not this pathway is the Core aging pathway we are looking for.

4. Epigenetic Alterations

The epigenome appears to be the master program which controls the expression of the genetic code by switching off and on genes and their proteins. There are multiple lines of evidence suggesting that aging is accompanied by epigenetic switches and that epigenetic perturbations can provoke, among other examples, progeroid syndromes in model organisms.

Furthermore, SIRT6 exemplifies an epigenetically relevant enzyme whose loss-of-function reduces longevity and whose gain-of-function extends longevity in mice (Kanfi et al., 2012; Mostoslavsky et al., 2006). Collectively, these works suggest that understanding and manipulating the epigenome holds promise for improving age-related pathologies and extending healthy lifespan. (Talens et al., 2012). In this Presentation, we will see more in detail how epigenetic changes involve alterations in (a) DNA methylation patterns, (b) post-translational modification of histones, and (c) chromatin remodeling.

5. Loss of Proteostasis

The decline in the protein quality of our cells, called the loss of protein homeostatis or proteostasis, is a fundamental mechanism of aging. (Powers et al., 2009). Even though our bodies have defenses against cellular stress,  after decades of repeated assaults by stressors such as free radicals, waste material and toxins, the proteins in our cells become damaged. As a result, they misfold. Amyloidosis from which many supercentenarian die is a misfoldment of protein problem All cells take advantage of an array of quality control mechanisms to preserve the stability and functionality of their proteomes.

Proteostasis involves mechanisms for the stabilization of correctly folded proteins, most prominently the heat-shock family of proteins, and mechanisms for the degradation of proteins by the proteasome or the lysosome (Hartl et al., 2011; Koga et al., 2011; Mizushima et al., 2008). The activities of the two principal proteolytic systems implicated in protein quality control, namely, the autophagy-lysosomal system and the ubiquitin-proteasome system, decline with aging (Rubinsztein et al., 2011; Tomaru et al., 2012), supporting the idea that collapsing proteostasis constitutes a common feature of old age. However, there are holistic and genetic ways to to improve proteostasis.

6. Deregulated Nutrient-sensing

The “deregulated nutrient sensing” was the first hallmarks to be described to influence aging in animals, through the insulin and IGF‐1 signaling pathway (IIS) (Kenyon, 2005). IGF‐1 is produced by several cells types (mainly hepatocytes) in response to GH release from the anterior pituitary. IGF‐1 has been shown to trigger the same intracellular signaling pathways stimulated by insulin. The IIS pathway is the most evolutionarily conserved pathway of aging, shown to modulate lifespan in model organisms across a great evolutionary distance from Caenorhabditis elegans to mice (Kimura et al., 1997; Tatar et al., 2001; Fontana et al., 2010; Kenyon, 2010b; Mercken et al., 2013). Accordingly, genetic polymorphisms/mutations that cause loss of function of GH, IGF‐1 receptor, insulin receptor or its downstream factors, have been implicated in human longevity as in model organisms (Fontana et al., 2010; Kenyon, 2010b; Tazearslan et al., 2011; Barzilai et al., 2012; Milman et al., 2014). Dietary restriction is a well‐known environmental signal shown to expand lifespan in eukaryote species, from yeast to primates (Colman et al., 2009; Fontana et al., 2010; Mattison et al., 2012).

The “longevity response” to dietary restriction is regulated by several nutrient‐sensing pathways: the kinase TOR, AMP kinase, sirtuins, and the IIS (Kenyon, 2005). Current available evidence  supports the idea that anabolic signaling accelerates aging, and decreased nutrient signaling extends longevity (Fontana et al., 2010). Even more, a pharmacological manipulation that mimics a state of limited nutrient availability, such as rapamycin, can extend longevity in mice (Harrison et al., 2009). In other words, less is more when it comes to this signaling pathway, as shown with worms, flies and mice (Fontana, op cit.) In addition to the IIS pathway that participates in glucose-sensing, there are three other pathways to the nutrient-sensing systems: mTOR, for the sensing of high amino acid concentrations; AMPK, which senses low energy states by detecting high AMP levels; and sirtuins. In Holistic medicine, we have techniques to help modulate these pathways.

7. Cellular Senescence

When telomeres shorten, cells can’t divide anymore, at which point they become senescent. When we are vibrant, senescent cells are thought to be cleared by the immune system, but when we are older, they stick around secreting harmful inflammation molecules and sticking to healthy cells. Canakinumab was manufactured to dampen this senescence inflammation called infammaging. But this drug has its limits. On the other hand, with holistic medicine, we have tools to assist in the removal of these inflammatory pro-aging senescent cells. (Source)

Technically, cellular senescence can be defined as a stable arrest of the cell cycle coupled to phenotypic changes (Campisi and d’Adda di Fagagna, 2007; Collado et al., 2007; Kuilman et al., 2010)  This phenomenon was originally described by Hayflick in human fibroblasts serially passaged in culture (Hayflick and Moorhead, 1961). Today, we know that the senescence observed by Hayflick is caused by telomere shortening (Bodnar et al., 1998), but there are other aging-associated stimuli that trigger senescence independently of this telomeric process. Most notably, non-telomeric DNA damage and de-repression of the INK4/ARF locus, both of which progressively occur with chronological aging, are also capable of inducing senescence (Collado et al., 2007).

In addition to DNA damage, excessive mitogenic signaling is the other stress most robustly associated to senescence. A recent account listed more than 50 oncogenic or mitogenic alterations that are able to induce senescence (Gorgoulis and Halazonetis, 2010).  All in all,  cellular senescence appears to be a beneficial compensatory response to damage that becomes deleterious and accelerates aging when tissues exhaust their regenerative capacity. It’s been shown that a moderate enhancement of the senescence-inducing tumor suppressor pathways appears to be able to extend longevity (Matheu et al., 2009; Matheu et al., 2007), and, at the same time, elimination of senescent cells in an experimental progeria model has delayed age-related pathologies (Baker et al., 2011). Therefore, two interventions that are conceptually opposite are able to extend healthspan. In this Presentation, we will examine the four phases of cellular senescence and conclude with a work on their relevance insofar as optimal longevity is concerned.

8. Stem Cell Exhaustion

Stem cell exhaustion unfolds as the integrative consequence of multiple types of aging-associated damages and likely constitutes one of the ultimate culprits of tissue and organismal aging. The decline in the regenerative potential of tissues is one of the most obvious characteristics of aging. For example, hematopoiesis declines with age, resulting in a diminished production of adaptive immune cells, a process termed immunosenescence, and in an increased incidence of anemia and myeloid malignancies (Shaw et al., 2010). A similar functional attrition of stem cells has been found in essentially all adult stem cell compartments, including the mouse forebrain (Molofsky et al., 2006), the bone (Gruber et al., 2006), or the muscle fibers (Conboy and Rando, 2012). Studies on aged mice have revealed an overall decrease in cell cycle activity of hematopoietic stem cells (HSCs), with old HSCs undergoing fewer cell divisions than young HSCs (Rossi et al., 2007). This correlates with the accumulation of DNA damage (Rossi et al., 2007), and with the overexpression of cell cycle-inhibitory proteins such as p16INK4a (Janzen et al., 2006).

As we oxidize (ie, age by losing electrons) our stem cells eventually lose their ability to divide and thus go into decline, at which point our bodies are unable to replace the stem cells that have migrated, differentiated, or died. Hence, the increase of age-related disorders, if only because the main function of stem cells is to replace damaged tissues. Because stem cell exhaustion is an important hallmark of aging, geroscientists are working on attempts to rejuvenate stem cells.  Promising studies suggest that stem cell rejuvenation may reverse the aging phenotype at the organismal level (Rando and Chang, 2012). Integrative and regenerative medicine focuses on the  early “banking” (storage) of stem cells that can be inoculated to worn out tissues when needed. Holistic medicine’s focus is on preserving and boosting one’s own stem cells. (Source)

9. Altered Intercellular Communication

Beyond cell-autonomous alterations, aging also involves changes at the level of intercellular communication, be it endocrine, neuroendocrine or neuronal (Laplante and Sabatini, 2012; Rando and Chang, 2012; Russell and Kahn, 2007; Zhang et al., 2013). As a consequence, neurohormonal signaling (eg, renin-angiotensin, adrenergic, insulin-IGF1 signaling) tends to be deregulated in aging as inflammatory reactions increase, immuno-surveillance against pathogens and premalignant cells declines, and the composition of the extracellular environment changes, thereby affecting the mechanical and functional properties of all tissues.

A prominent aging-associated alteration in intercellular communication is ‘inflammaging’, i.e. a smoldering pro-inflammatory phenotype that accompanies aging in mammals (Salminen et al., 2012). Inflammaging may result from multiple causes such as the accumulation of pro-inflammatory tissue damage, the failure of an ever more dysfunctional immune system to effectively clear pathogens and dysfunctional host cells, the propensity of senescent cells to secrete pro-inflammatory cytokines (see section on Cellular Senescence), the enhanced activation of the NF-κB transcription factor, or the occurrence of a defective autophagy response and SIRT6 may also down-regulate the inflammatory response through deacetylation of NF-kB subunits and transcriptional repression of their target genes (Kawahara et al., 2009; Rothgiesser et al., 2010).

Beyond inflammation, accumulating evidence indicates that aging-related changes in one tissue can lead to aging-specific deterioration of other tissues, explaining the inter-organ coordination of the aging phenotype. In addition to inflammatory cytokines, there are other examples of ‘contagious aging’ or bystander effects in which senescent cells induce senescence in neighboring cells via gap junction-mediated cell-cell contacts and processes involving ROS (Nelson et al., 2012). The microenvironment contributes to the age-related functional defects of CD4 T cells, as assessed by using an adoptive transfer model in mice (Lefebvre et al., 2012). Likewise, impaired kidney function can increase the risk of heart disease in humans (Sarnak et al., 2003).

Summary on the First Nine Hallmarks

The common characteristic of the first four hallmarks is the fact that they are all pretty much delerious to the body’s ability self-repair and thrive. This is the case of DNA damage, (including chromosomal aneuploidies), mitochondrial DNA mutations, telomere loss, epigenetic drift, and defective proteostasis. These hallmarks are often initiating and their damaging events progressively accumulate with time.

The next hallmarks appear to generate compensatory mechanisms that can mitigate the nefarious effects of the first hallmarks. However, while at low levels, they mediate beneficial effects,  at high levels, they can become deleterious. This is the case for senescence, which protects the organism from cancer, but in excess  promotes protein misfoldment and aging. Similarly, reactive oxygen species (ROS) mediate cell signaling and survival, but at chronic high levels  produce cellular damage. And while optimal nutrient-sensing and anabolism  mechanisms are key for survival,  in excess then become counter-productive.  These hallmarks can be viewed as designed for protecting the organism from damage or from nutrient scarcity, but when exacerbated or chronic, they generate further damage.

As for the last two hallmarks, stem cell exhaustion and altered intercellular communication, these can further messed up the body’s integrity by impacting its entire tissue homeostasis system. Notwithstanding the interconnectedness between all of these hallmarks and their evolutionary “conspiracy” to bury the host, happiness and holistic medicine can attenuate some of these mechanisms while reversing others.

Complementary Hallmarks

The Happiness Medicine Institute’s excutive committee has identified additional hallmarks that both account for aging and offer possibilities for rejuvenation. First off, we have the Autophagy system whose mechanism of action is key insofar as removing metabolic wastes. Likewise with the  Lysosome Degradation system. As for the Tissue and DNA repair system, new findings show that humans have some control over its reinforcment. Then we have Circadian Rythms mechanism. This hallmark relative to the circadian pathway is relatively new. The 2017 Nobel Prize in Physiology (Medicine) went to scientists who dug deep to unravel some of the mysteries of circadian biology. When humans don’t respect Nature’s rhythms like the sleep-wake (melatonin-cortisol) cycle, aging is accelerated big time.

Another new player is the Circular RNAs (circRNAs) system. CircRNAs are a newly appreciated class of RNAs found across phyla that are generated most commonly from back-splicing of protein-coding exons. Recent profiling of circRNAs genome-wide has shown that hundreds of circRNAs dramatically increase in expression during aging in the brains of multiple organisms. No other class of transcripts has been found to show such a strong correlation with aging as circRNAs. They could play a key role aging process. (Source)

Then we have the Endocannabinoid engine. The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system. (Source) The endocannabinoid system is also involved in regulating a variety of physiological and cognitive processes including but not limited to general homeostasis and fertility, pregnancy, postnatal development, appetite, pain-sensation, mood, memory, neurogenesis, inflammation, the immune system and, among other biological systems,  the longevity pathways, including, but not limited to brain rejuvenation (neurogenesis),  significant Lou Gehrig’s Disease life extension and general longevity via the dietary restriction signaling pathway. This biological ECS system is at the heart of evolutionary biology, ontological experience and optimal longevity.  It is so important that scientists have created a new deficiency disease called “Clinical Cannabinoid Deficiency” disorder. (Source)

While the body is able to activate the ECS’s endocannibinoid receptors on its own, given mainstream’s toxicity, stress and conventional synthetic drug and trauma based medicine, much of the human and mamalian endocannabinoid system is under-activated or inhibited. Hence, the lack of wellbeing and joie de vivre.. A holisti lifestyle with certain cannabinoid plants can partially remedy this deficiency, thanks to which a healthy lifespan can be better expressed  Helichrysum, Echinacea, (containing cannabinoids called N-alkylamides),  liverwortblack pepper and a few others plants that contain cannabinoids can help, but cannabis is by far the most abundant and rich in healthy and longevity producing cannabinoids, over 80 of them, all integrated within the “whole” in the right proportions. (Source)

With the recent “revolution” in medicine concerning the microbiome, (which in reality is over one hundred years old), we feel that we must  characterize this field as a major hallmark of aging, if only because these little critters within, 700 trillion of them, have close to 8 million genes that cross-talk with our 23,000 eukaryotic genes. (ie, most medical journals speak about 2.4 million genes, but official sources point to 8 million, Source). Indeed, the Microbiota’s and the Microbiome’s networking are key not only in health and diseases, but also in longevity. As we will see, the very same bacteria who have been so essential in the complexification of Life over the last 65 millions of years are living in our guts churning away to make us either sick and short lived or healthy and long lived. For example, supercentenarians have a diversed amount of youthful bacteria whereas sick people who die young have lots of dysbiosis. Microbiome science has been one of the most recent scientific revolutions in Medicine, disproving a big chunk of mainstream medical dogmas. Today, to the bacteria-laden microbiome, micro-biologists have identified inter-related networks of viruses, archeae, fungi, yeast and parasites that all contribute one way or another to the process of human biology, chronic diseases and aging. There are few other mechanisms that we see as Hallmarks, but for now, the ones we have mentioned should be enough to better understand and act upon Evolution’s “genetic curse” or mistakes: short human lifespans characterized by narcissistic predation, diseases, suffering and the deficiency of JDV.

Longevity Mechanisms in supercentenarian & long-lived animals

In this Presentation, we will examine a few survival and longevity mechanisms that allow certain animals to both avoid cancer and optimize longevity way better than most humans. First, we will look at a few large animals. According mainstream science theory, the larger the animal, the more the animals risk for cancer should go up. This correlation has often been confirmed in humans , i.e., the larger and taller humans have way more cancers than smaller humans. (Source) The explanation is straightforward. In a multicellular organism, cells must go through a cell cycle that includes growth and division. Every time a human cell divides, it must copy its six billion base pairs of DNA, and it inevitably makes some mistakes. These mistakes are called somatic mutations and carry with them high risks for carcinogenesis. Therefore, in theory, large bodied and long-lived organisms should face a higher lifetime risk of cancer simply due to the fact that their bodies contain more cells and will undergo more cell divisions over the course of their lifespan. At least way more than a  smaller human. The evidence proves the contrary .(Source)

However, a close look at data confirms that this above-mentioned correlation does not apply to animals, including mammals, as long as they are in the wild.  In effect, as long as they are in the wild and kept away for human corporate garbage food and pollution, large animals like whales (who have 2000 times more cells, so they should have 2000 times more random cancer risks (Source)), sharks and elephants not only have very little (if any) cancer, but they surpass Hayflicks “biological clock” limit way better than humans by living hundreds of years.

By sequencing the genes of some of these animals, scientists were able to determine that these animals have perfected  some of the same biological mechanisms humans have. For the  bowhead whale (Balaena mysticetus)  mammal, its innate intelligence has developed, inter alia, strong tumor suppressor genes (Source), hence, it’s ability to multiply trillion and trillions of cells without getting cancer and living over 200 years, as long as they avoid fishermen’s nets. (Source)

The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance”(Source)

Let’s look at lobsters. There is a debate among the scientific community whether these red ocean dwellers are biologically immortal animals or not because they continuously grow and reproduce, unless killed by predators.  One lobster captured off the coast of Newfoundland was estimated to be 140 years old. (Source)  These lobsters are like those big female turtles (tortoises) who also get to reach the supercentenarian status, the more they age, the more eggs and fertility they have. The New York Times reports that turtles might even be able to live indefinitely if they are able to avoid predators and disease.

Then we have a special A islandica clam called “Ming the Mollusk”,who was able to have reached over 500 years. (Source) Scientists believe that the ocean quahog’s longevity is related to its resistance to oxidative stressors.

 “Our findings demonstrate an association between longevity and resistance to oxidative stress–induced cell death in A islandica, consistent with the oxidative stress hypothesis of aging and provide justification for detailed evaluation of pathways involving repair of free radical–mediated macromolecular damage and regulation of apoptosis in the world’s longest-living non-colonial animal.” (Source)

Greenland sharks are also interesting super supercentenarians since they can surpass 400 years old and the don’t seem to reach sexual maturity until they are 150 years old, which is quite an anti-Darwinian behavior. The deep sea Rockfish also live for hundreds of years. What are their secrets ? Brandt’s bats, small mammals found throughout Eastern Europe and parts of Asia also live long lifespans, over 40 years, as long as they stay in the wild and are not killed. (Source)  Maybe their secret is enjoying “siesta”., because this species loves to hibernate. They also have interesting hormone receptors. As for the Proteus fish, these can live for over 100 years. Proteus has a high tolerance to low oxygen levels, something that’s also true of naked mole rats and ocean quahogs.

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Top: The naked mole rat who also broke the world record for longevity in its category. He-she is one of the H.M. Institute’s Heros as the NM Rat has demonstrated successful Longevity pathways that are relevant to the H.M. Institute’s Optimal Longevity Model.

Negligible senescence in the longest living rodents, the naked mole-rats & their DNA repair system

Another animal, in this case a mammal, that is studied a lot in longevity medicine is the naked mole rat. This rodent is smaller than the common rat, but lives  up to 32, as opposed to 3 years for the common rodent and like Jeanne Calment, holds the record for the longest living sentient being in its category, in this case the rodent genus. (Buffenstein R, Jarvis JU (May 2002). “The naked mole rat–a new record for the oldest living rodent”. Science of Aging Knowledge Environment. 2002 (21): pe7. (Source) And this naked rat lives long by staying healthy nearly to the end of their lives just like Jeanne Calment. What is his or her secret ? One possible secret may be hyaluronic acid. Just like one of  Calment’s “secrets” to her smooth skin was Mediterranean oil olive she loved to pour on her skin, the naked rat also produces a vast amount of hylaluronic acid juice for an extra glowing naked body, which may be in part due to the overexpression of the gene that controls this natural beauty molecule. Indeed, the Naked mole rat produces an unusual form of hyaluronic acid, and in very high quantities, so that very large and de-bonded acid molecules saturate the tissues, providing antioxidant properties and  possibly blocking cancer growth. There are other theories why the naked rat is resistant to cancer. (Source) This mammal also benefits from a clean and healthy vascularture, much more robust that the shorter-living rats. (Source) The reason for their longevity is still not settled, but at this point, it’s believed to be related to their ability to substantially reduce their metabolism during hard times, and so prevent aging-induced damage from oxidative stress. (Source) Their longevity has also been attributed to “protein stability.” (Pérez VI, Buffenstein R, Masamsetti V, Leonard S, Salmon AB, Mele J, Andziak B, Yang T, Edrey Y, Friguet B, Ward W, Richardson A, Chaudhuri A (March 2009). “Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat”Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3059–64. Thanks to their extraordinary longevity, an international effort was put into place to sequence their genome. Further transcriptome sequencing (ie,  transcriptome is the set of all RNA molecules in one cell or a population of cells) revealed genes related to mitochondria and oxidation reduction processes to have high expression levels in the naked mole-rat when compared to mice. (Source) In this perspective, the DNA repair transcriptomes of the liver of humans, naked mole rats and mice were compared. (Source) And low and behold, it was proven beyond any reasonable dought that these naked rats expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher level than did the other rodents.  mouse. Furthermore,  several DNA repair pathways in both humans and naked mole rats appeared to be well activated (expressed or up-regulated) in relation to the other rodents. (Source) These findings suggest that  DNA repair is Key in longevity.

Gompertz Aging law and  Biological “Immortality”

Biological immortality (sometimes referred to bio-indefinite mortality) is a state in which the rate of mortality from senescence is stable or decreasing, thus decoupling it from chronological age. Negligentable senescence can be included in this realm. Various unicellular and multicellular species, including some vertebrates, achieve this state either throughout their existence or after living a very long lifespan, cruising without diseases in a phase called “late-life mortality plateau” which some supercentenarian humans like Ms Calment have experienced. A biologically immortal living being can still die from means other than senescence, such as through injury or disease. Or they can slowly die at a very old age from a lack of ATP energy, like some lobsters, when they don’t have enough energy to build a new big shell to protect themselves from predators. According to mainstream Darwinian thinking, senescence or aging is necessary among humans because first, aged beings can’t reproduce well past their “prime” and make strong & healthy offsprings and second, there are not enough resources for everyone if people stayed around for too long.

In this Presentation, we will debunk both these propositions. Similary with Gompertz Aging law. This law provides (mathematically) that the increase in mortality with the passage of time (aging) tends to be logarithmic (exponential) (Source)  In other words, the more we live, especially after 40 years old, the faster and faster our tissues get metabolically impaired. Concomitantly, the expression of deleterious genes accompany this maccabre dance to the graveyard. While it’s true that some people can oxidize and age faster and faster as death approaches, (Source), holistic lifestyle can significantly minimize this pace while optimizing the JDV space.

Tentative Concluding Remarks  on Senescence and Aging mechanisms

One of the key lessons the ageless Hydra gives us is based on stem cells that don’t decline over time. (cf stem cell biology of the hydra). With an abundant and continuous supply strong stem cells and an ability to eliminate the cumulative buildup of misfolded proteins and aggregate waste products, the entire Hydra organism can be replaced over a short period of time provided it can find the metabolic resources to do so (ie, as it does  with its symbiotic friendship with algae and corrol reefs).

Thomas Bosch from the Zoological Institute of Kiel University, who led an important Hydra study wrote that the longevity gene  “… FoxO has been found to be particularly active in centenarians – people older than one hundred years – which is why we believe that FoxO plays a key role in ageing – not only in Hydra but also in humans”(Source) And one of the reasons that this longevity gene FoxO is important is because it:

“ .. plays a decisive role in the maintenance of stem cells. It thus determines the life span of animals, from cnidarians to humans”.(Source)

As suspected then, The “Grand Master” called Evolution or God has designed foxy genes to better control and activate longevity via multiple mechanisms including but not limited via the production of an abundant supply of telomerase-rich stem cells.

“These findings contribute to a molecular understanding of Hydra’s immortality, indicate an evolutionarily conserved role of FoxO in controlling longevity from Hydra to humans, and have implications for understanding cellular aging (Source)

To optimize longevity then, what is therefore needed is a continuous supply of quality food and stem cells and a system or systems of removing aggregate debris and senescent cells. With a little help from our trillions and trillions of gut critters (archae, bacteria, fungi, and, inter alia viruses) and holistic savoir-faire, the immune and autophagy systems can satisfactorily accomplish this last task.

The Workshop’s Guiding Hypothesis on a unified theory of aging

For now, the Happiness Medicine Institute’s working hypothesis derives from what we have advanced so far, in particular that the organismal process of aging and perhaps life itself appear to be strongly influenced if not governed by an ancestral bacteria, the mitochondria, whose intelligence wiggled itself into an eukariotic cell and thanks to its small genome, cross talked with the eukariotic cell’s own nuclear genes for the synergistic benefit of both entities (the eukariotic cell and the mitochondria), thanks to which Life and it’s maintenance were able to fine-tune from over one billion years ago to today. After many millions of years, this process evolved in millions of  different Life forms, including human life.

One piece of evidence that supports this claim that the evolutionary origin lies in the mitochondria can be found in single-celled protozoans. In the ciliates (e.g. paramecium), telomerase is not expressed in mitosis (when the cell copies itself), (Source) but only when it conjugates (recombining genes with other individuals) with another. (Source) Thus a cell that self replicates without mixing its genes with another is designed to quickly die of cell senescence, it’s mission of self replication having occurred. But for cells that self replicate by exchanging genes with a partner, here,  teolmerase gets expressed. And this gene, called TERT is deeptly connected to the mitochondria. This mechanisms came about maybe a billion years ago.

Because most of the other important aging pathways we have examined are also under the strong influence of the mitochondria, in particular senescent cells, the P53 and stem cells, we therefore hypothesize that the central key to optimal longevity lies within both the mitochondria’s genome and its oxidative phosphorylation & ATP-AMPK system as well as the mitochondria’s brethren, within the microbiota and the nDNA-mtDNA circuit or axis and the Epigenome. Telomere shortening is still a relevant pathway, but since new findings have emerged, we are for now putting the Telomere length (TL) factor on a back-burner. The Happiness Medicine Institute has elaborated a Theory on Aging, but it is not yet finished.

We are now ready to examine how holistic medicine can contribute to down-regulate the aging mechanisms and optimizing healthy lifespans. But first, we need to identify conventional medicine’s research limitations (weaknesses) and delve into methodology

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Session G: Research, Methodology & Legal Perspectives

“The case against science is straightforward: much of the scientific literature, perhaps half, may simply be untrue. Afflicted by studies with small sample sizes, tiny effects, invalid exploratory analyses, and flagrant conflicts of interest, together with an obsession for pursuing fashionable trends of dubious importance, science has taken a turn towards darkness.” (Lancet Journal)

Medicine is a field of knowledge that is fraught with unreliability, contradictions, incompetence, careerism, conflicts of interests, fraud and change. Its published research findings are often refuted by subsequent evidence. Refutation and controversy is seen across the range of biomedical research designs, from clinical trials and traditional epidemiological studies to the most modern molecular research. Furthermore, much of biomedical research isn’t even reproducible.  And there is increasing concern that in modern conventional biomedical research, false findings may be the norm.  Integrative medicine is better, but also has it’s flaws.

“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of the New England Journal of Medicine” (“Dr. Marcia Angell, a physician and longtime Editor in Chief of the New England Medical Journal (NEMJ), which is considered to another one of the most prestigious peer-reviewed medical journals in the world). (Source)

In this Presentation, we will review the relevant facts with regard to methodological problems.

How to Find reliable scientific Data

Not always, but too often conventional medicine’s research experts use bias, reductionism and misleading statistical and rhetorical tricks to promote just about anything they get paid for. Integrative medicine’s experts are not immune from this human frailty either, occasionally using and abusing the People’s credibility and science virginity with biased studies on certain supplements, nutritional regimes, procedures and diagnosis tools. But the most pervasive harm that kills and maims the most patients (in the millions each year) comes from spined government-promoted studies that are ofen financed by conventional science’s food, agricultural, pharmaceuticaland medical industries, in particuar with regard to oncology, cardiology, neurology and metabolic diseases. A few illustrations will follow.Thereafter, we will give guidelines that can help to navigate the system so thataccurate and relevant data can be established.

Are Animal Experimentation studies reliable ?

A careful look at the litterature shows that more often than not, animals will react differently than humans when they are being used as experimentation agents. Even if we share many common genes, they are still metabolically quite different. Which means that many times, they will produce physiological effects that are different from humans and the information collected from animals will be expensive and not be very useful for root cause based human medicine.  Yet, animal research is at the core of  American biomedical research..

“The resulting evidence suggests that the collective harms and costs to humans from animal experimentation outweigh potential benefits and that resources would be better invested in developing human-based testing methods. (Source)

For example, while over  100 human clinical trials testing anti-inflammatory drugs have failed, these have all been successful in mice trials. There have been a lot of similar results in the biomedical field with other experimentation.

“A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models mimic human inflammatory diseases are nonexistent. Here, we show that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another. Among genes changed significantly in humans, the murine orthologs are close to random in matching their human counterparts (e.g., R2 between 0.0 and 0.1). In addition to improvements in the current animal model systems, our study supports higher priority for translational medical research to focus on the more complex human conditions rather than relying on mouse models to study human inflammatory diseases” (Source)

On the other hand, if the goal is to better undersand biochemical pathways and metabolic cascades regarding physiological processes like aging, then the use of rodents, worms, yeast and flies can be useful because we do share a pool of similar gene groups with all of cellular “Life”, hundreds of gene groups that have been identified 3.5 billions years ago from what is called the “Last universal common ancestor” and 6,331 gene groups common to all living animals that have been identified from a single most recent “common universal ancestor”  around 650 millions years ago in the Precambrian. (Cf. Borenstein, Seth (13 November 2013). “Oldest fossil found: Meet your microbial mom”. Associated Press)

So for  the task of better understanding underlying physiological mechanisms, animals have helped us, and in actuality, the mouse has been instrumental in 51 Nobel prizes. But for root-cause holistic medicine, the sacrifices of animals on the altar of medical research is not necessary. On the other hand,  for conventional medicine bent on treating symptoms with synthetic drugs, experimenting with animals is a sine qua non condition to research. But if root causes are the issue, then HM Institute posits that it would be more cost-effective, efficient and ethical to experiment directly with humans.

 Medical Law: Liability, the Standard-of-Care & the Legal Protection of Alternative Medicine &  Innovative Medical Research

“The medical profession is being bought by the pharmaceutical industry, not only in terms of the practice of medicine, but also in terms of teaching and research. The academic institutions of this country are allowing themselves to be the paid agents of the pharmaceutical industry. I think it’s disgraceful.”  Arnold Seymour Relman (1923-2014), Harvard Professor of Medicine and Former Editor-in-Chief of the New England Medical Journal

We need to invoke the Law because most (not all, just most) of Mainstream medicine can not continue to be one of the top killers (and hence anti-longevity perpetrators) without the active complicity of the legal system. By “legal system” we include courts, law schools, law-makers, their donation lackeys and a few other players. In other words, it’s impossible to understand, let alone change the medical system and public health policies without examining the law and its limitations.

In this perspective, one of key notions this Workshop will often speak about is the “standard of care”. We think of the “standard-of-care” as the definition of proper scientifically based care that a patient receives from the medical establishment. However, this representation is misleading. Standards of care in the US are not based on Science. They are based on what the “Medical Community” thinks is Science. Ther a huge difference between what mainstream trained doctors think of what Science is and what Science is. We will therefore demonstrate with a decent preponderance of the evidence that the primary function of conventional medicne’s  “standard of care” mantra is to quickly and impersonally deliver symptoms-only  cash-maximizing medical treatment. If only to insure that the patient will come back for more.

In this presentation, we will also share power point information for the benefit of alternative health-care providers on liabilities as well as on legal protection techniques that can be implemented in order to avoid legal pitfalls and thrive as best as possible under the present circumstances. In addition, key arguments that can be invoked in a Court of law when arbitrary legal attacks hit (from Medical Boards, FDA, FTC, frivolous patients, et al) will follow as well as a brief discussion of Patients’ Fundamental Health Rights and  Doctors’ Duties.

Case Study on Autologous Stem Cells, Cancer and the FDA

The Fact: Just recently, the FDA with the US Department of Justice filed suit against American stem cell clinics alleging that these clinics are using unproven and damaging stem cell therapies. In this Presentation, we will show to what degree law and medicine are intertwined. (Case study from the Holistic Justice Institute).

 Clinical Practice

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Top: coronary heart disease can be easily detected with a simple ear examination anyone can do

Session C: Holistic Cardiology in a Nutshell.  Extended Lifespans need Strong Hearts & Smooth Vasculature

“Keep a quiet heart, Sit like a tortoise, Walk sprightly like a pigeon, Sleep like a dog”  (Longevity advise from Li Ching-Yuen. Li was a mountain herbalist & a wine enthusiast who seemingly lived to 197 years.

Healthy extended lifespans need healthy epithelium. If the lining of the vessel walls are not healthy, all of the other tissues are affected. Blood flow is key and both holistic and nutritional medicine focus on this priority by prescribing daily servings of nitric oxide promoting dark green veggies, inter alia. (legal jargon for “among other elements”). (Source) When the epitehlium is damaged,  Cardiovascular diseases (CVD) abound. CVDs in the US constitute both the First cause of premature death and the easiest epidemic to fixed holistically. If holistic and happiness medicine were the standards of care, conventional cardiology would go bankrupt within days, thanks to which millions of Americans would avoid CVDs and get closer to acheive their 120 years potential.

In this Presentation, we will examine the hard evidence that shows that most of conventional cardiology is both outdated and laden with deleterious consequences that hinder the People’s birthright to live a healthy lifespan to 120 years. Concomitantly, we will prove via published power point studies that  integrative and holistic cardiology are clinically safer, more effective and cost-friendlier.

 Erectile Dysfunction (E.D.) is a  “CVD canary in the Coal Mine” symptom that justifies an immediate rendez-vous with Cardiology Monitoring

The evidence is crystal clear, libido health for both men and women declines when arteries get clogged up. ED is the highest CVD risk, fourty times more than other risks factors, including high blood pressure and low NO (nitric oxide). It is a red flag,  what the experts call a “canary in the  coal mine”. As a consequence, an immediate check-up at the cardiologist’s office as well as a blast of Omega 3 rich algae oil and a scoop of powedered flax seeds may be indicated pronto.

Lifestyle and nutrition have been increasingly recognized as central factors influencing vascular nitric oxide (NO) production and erectile function. This review underscores the importance of NO as the principal mediator influencing cardiovascular health and erectile function. Erectile dysfunction (ED) is associated with smoking, excessive alcohol intake, physical inactivity, abdominal obesity, diabetes, hypertension, and decreased antioxidant defenses, all of which reduce NO production. (…)  In men aged <60 years and in men with diabetes or hypertension, erectile dysfunction can be a critical warning sign for existing or impending cardiovascular disease and risk for death. The antiarrhythmic effect of omega-3 fatty acids may be particularly crucial for these men at greatest risk for sudden death.(…)…” (“The link between erectile and cardiovascular health: the canary in the coal mine”, Am J Cardiol. 2011 Aug 15;108(4):599-606)

In this Presentation, we will talk about a few holistic tips to restore both the endothelium  and glandular health. These tips are way safer and more efficient than viagra and any other drugs on the market. Without proper cardiovascular “self-care”, human lifespan is unlikely to reach 80 years old.

Debunking myths & misleading claims regarding Fats

There is no question that humans need cholesterol and lots of it. That’s why human liver cells as well as intestinal, reproductive and adrenal cells make it. Cholesterol is so vital for all of our cells’ membranes, hormones inter alia, that humans also have a HDL-based cholesterol recycling system. Recent well designed studies confirm that those who die the youngest have low cholesterol (Source) while those who live the longest and healthiest have more cholesterol.

“High LDL-C is inversely associated with mortality in most people over 60 years”. (BMJ, Source)

However, there’s controversy. When the body’s sensors register dietary cholesterol, (coming from animal sources), it signals  our cells to stop producing endogenous cholesterol. So is this “replacement” deleterious ? While most serious food scientists agree that we need cholesterol, many disagree with regard to the source and amount of cholesterol. The Keto-paleo schools argue that good heath requires lots of  dietary cholestrol from animals while other food scientists argue the opposite, that the body’s own cholesterol should be the only source of cholesterol.

In this perspective, Dr. William Clifford Roberts, Executive Director of Baylor Heart and Vascular Institute and long-time Editor in Chief of the American Journal of Cardiology, has argued  that atherosclerosis has only one single cause, dietary cholesterol. (Source)  In other words, neither being stressed out, overweight, smoking, diabetic, sedentary are sufficient factors by themselves to trigger CVDs. Roberts concluded that the sine qua non condition for a fatal or nonfatal atherosclerotic event like a heart attack is a high cholesterol levels. Source)  Other cardiologists like Drs Esselstyn, Kahn and Ornish argue that high animal dietary cholesterol and saturated fats not only promote CVDs, but they also promote many other chronic diseases, from  kidney failure to cancer and fertility dysfunctions. And still other published authors  show that statin drugs un-necessarily reduce needed cholesterol while depleting Co-Q-10 enzyme.

On the other hand, a landmark systematic review and meta-analysis of observational studies showed no clear correlation between saturated fat consumption and all-cause mortality.

“Conclusions Saturated fats are not associated with all cause mortality, CVD, CHD, ischemic stroke, or type 2 diabetes, but the evidence is heterogeneous with methodological limitations. Trans fats are associated with all cause mortality, total CHD, and CHD mortality, probably because of higher levels of intake of industrial trans fats than ruminant trans fats. Dietary guidelines must carefully consider the health effects of recommendations for alternative macronutrients to replace trans fats and saturated fats”. (BMJ 2015, Source)

So does CVD pathogenesis and treatment require a paradigm shift ? Should we now all eat lots of  animal cholesterol and saturated fat ? This Presentation we will attempt to clarify the cholesterol-fat debate and determine safe holistic protocols that safely promote endogenous cholesterol as well as all of the other types of good fatty acids the body and brain need for optimal functioning.

To Salt or Not to Salt ? The Evidence on Salt and CVD Diseases

In this Section, we will examine the salt question. Studies in Europe concluded that more salt is better for the health than less salt, including for CVD patients, provided the salt is not toxic and of the French celtic type, full of healthy minerals and trace minerals, over 60 of them. In the US, studies showed the opposite effects, the more salt was consumed, the more arterial stiffness, high blood pressure and CVD were seen. The Centers for Disease Control and Prevention (CDC) states that excess sodium can increase blood pressure and the risk for a heart disease and stroke in some individuals. (Source). Therefore, health authorities recommend limitations on dietary sodium. The United States Department of Health and Human Services recommends that individuals consume no more than 1500–2300 mg of sodium (3750–5750 mg of salt) per day (Source).

Japanese experts also found a link between higher sodium intake and an increased risk of hypertension (Takase et al, Journal of the American Heart Association, July 29, 2015; Murai et al, Journal of Hypertension, June, 2015, (Source). And a meta-analysis of 34 randomized trials found that modest salt reduction, to around 3 g/day, for at least a month lowered blood pressure significantly (He et al, BMJ, April 3, 2013). And still another study showed that everyone reacts differently,  not everyone benefits from cutting salt, this study found no connection between sodium or potassium intake and elevated blood pressure (Sharma et al, Journal of Clinical Hypertension, April 11, 2014 (Source). And still other studies demonstreated that low salt (below 3 grams per day) was the worse of the worse in termso of promoting  CVDs. (Source)

“Published in The Lancet, the study found that low salt, or sodium, intake may raise the risk of heart attack, stroke, and death, compared with an average salt intake. (Source)

In this Presentation, we will debunk myths, unmasks flawed studies and show the hard evidence with regard to the salt question.  There is no question that Sodium is an essential nutrient, its ions are needed in small quantities by most living things, as are chloride ions. Salt is involved in regulating the water content (fluid balance) of the body. The sodium ion itself is used for electrical signaling in the nervous system and other bodily functions. (Source) One of the keys lies in the quality of the salt as well as its synergy with other food spices and food. Refining salt so that  only sodium chloride is left is a miserable mistake like all refinement. Salt should be consumed unrefined and with quality food.  It is thus likely that most American conventional and integrative cardiologists are  misguided they recommend law-salt intake.

Case Studies: Reversing Cardio-vascular diseases (CVDs) with Holistic Cardiology

In this section, we will examine CVDs patients who have been able to reverse their cardiovascular conditions. In particular, we will look at the holistic rehabilitation of stroke patients and the holistic reversal of CVDs, in particular coronary disease.

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Session D: Detoxification, Fasting & Cleansing for Optimal Longevity

 “There were never so many able, active minds at work on the problems of disease as now, and all their discoveries are tending toward the simple truth that you can’t improve on nature.” (Thomas Edison, 1902)

In Conventional medicine, the Government’s N.I.H experts claim that  “…there isn’t any convincing evidence that detox or cleansing programs actually remove toxins from your body or improve your health. Weight loss on a detox diet may be because these diets are often very low in calories” (Source) while independent but conventional scientists in peer-reviewed studies will outrightly debunk detoxification techniques as being useful for disease reversal and longevity. On the other hand, experts in the integrative-functional-holistic fields validate detoxification’s powerful impact on healing. After assessing the pros and cons of holistic and metabolic detoxification, the Happiness Medicine Institute has determined that detoxification in general is overwhelmingly supported by the evidence and constitutes a powerful rejuvenation technique, notwithstand a few isolated and unsupported cash-flow motivated claims in the alternative health field.

In this section, we will thus compare the arguments and facts with regard to the pros and the cons of different detox techniques and then make a reasonable determination as to where the preponderance of the evidence lies regarding some of the more popular detoxificataion claims that are invoked in the integrative and holistic fields: in particular: anemas, colonics, saunas, ionic foot baths, detox supplements (clays, ALA, Nac, milk thistle etc), diet, fasting, sweating, exercises and more.

The Body’s has Six Key Metabolic Detoxification Pathways that need to be activated and fined-tuned

There are 6 Phase II detoxification pathways in the body that need to be in good shape for Life to durably withstand the passage of time. Each conjugation pathway serves a specific purpose of detoxifying certain toxins and toxicants. These biochemical pathways require specific nutrients to function. These 6 detoxification pathways include: Glutathione conjugation, Methylation, Sulfation, Acylation/Glycation, Acetylation, and Glucuronidation. In this presentation, examine how to best activate these pathways.

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Sauna, Hydrotherapy & Hot tub Therapies

While most health practitioners will agree with the importance of using a Sauna to better detox, most health practitioners will not recommend safe and efficient holistic protocols that should accompany sauna therapy as sweating is not enough to get rid of toxicants, if only because some of the released toxins and toxicants find their way back into the blood circulation where they can create havoc. In this Presentation, the H.M. Institute’s Holistic Approach to Sauna Detox and Hydrotherapy will be detailed.

Removing Glyphosate ASAP

Every generation and civilization has major toxicity challenges. In this Presentation, we will look at Glyphosate’s impact on over 15 common diseases and chronic conditions, delve into different protocols that can safely remove most of this ubiquitous poison. We will conclude with a word on testing.

Home Detox from the Sick Building Syndrome

We will also review the “home toxemia” challenge, the list of which is extensive. This Seminar’s section is important because holistic medicine’s first task is to identify the deep underlying causes to diseases and many of these causes are found in one’s living area and in the workshopee’s lifestyle. Just the air inside most homes have been determined to be up to five times worse than the air pollution outside, wrote the U.S. Environmental Protection Agency (ie, other sources say 10 times worse), while the W.H.O found that 4.3 million people die each year prematuraly from the air inside homes. (Source) To make matters worse, the non-profit Environmental Working Group tested over 2,000 cleaning products, and found that most of them contain chemicals that are linked to asthma, allergies, or even cancer. EWG found that, because American product manufacturers or distributors aren’t required to disclose all their ingredients, many of them don’t. Still worse, with electromagnetic and dirty electricity pollution, formaldehyde and arsenic in wood, lead in pipes, radon under the house, fire retardant outgasing from sofas and beds (toxic to the thyroid), mercury vapors in people’s mouths, deleterious bacteria and molds on the walls, and, among many other toxins, VOCs and phthalate esters all over (ie, these are plasticised polyvinyl chloride (PVC) materials used in floor (especially carpets) and wall covering materials, shower curtains, adhesives, synthetic etc), people develop respiratory, cancer, auto-immunity diseases, among other ailments.

Occupants of water-damaged buildings (WDBs)

Studies have demonstrated over and over that the indoor air of WDBs often contains a complex and deleterious mixture of fungi, mycotoxins, bacteria, endotoxins, antigens, lipopolysaccharides, and biologically produced volatile compounds. Occupants of water-damaged buildings (WDBs) can be victime to this SBS (sick building syndrome) involving multiple organ systems.

This Presentation will therefore look into this problem and also examine toxic garden, toxic cloth, toxic body & home care products that are injurious to health while not being effectively regulated by the Industry, let alone by the Government’s agencies.

 Fasting  Techniques for Detoxification

In this Presentation, we will briefly look at different types of Fasts, their benefits, limitations and risks. Some of the fasting techniques we will examine are the following:   fruit fasts,  mono-diet fasts, raw juicing fasts, caloric restriction, veggie-fruit rawfood diets, the Daniel fast, the “feast and famine” protocol, water fasts and, among others, the “warrior diet fast” (eating once a day), the intermittent and the alternate fast, all of which are new labels to simple millennia-old holistic techniques based on shutting down the gastric juices and exogenous food supply (and-or significantly reducing them) so that the body can better oxygenate, alkalinize, mineralize, detox, heal, retore homeostasis  and rejuvenate. Water and juice fasting should be preceded with other types of detoxification so that released toxins and toxicants can be removed in a more gentle way. Without propre preparation, long juice and especially water fasts can lead to serious toxemia complications. (Link)

 On the New “fasting mimicking diet” trend being adopted by the Anti-Aging Community

For the fasting mimicking diet (FMD), Professor Longo (presently director of the UCLA Longevity Institute) believes that his five days per month caloric restriction diet can mimic the effects of fasting with a meal program that is designed to inhibit the same metabolic pathways fasting would, thereby providing the body with nutrients that do not trigger the body’s growth responses. (See video below)

While Longo’ experimentations do show rejuvenation benefits from this “fasting mimicking diet”, we will argue that this mimicking diet can’t surpass a water-only fast, or even couple other types of light-food or herb-juice fasts. (Link)

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Juicing Cleanses

Like herbal teas, juice cleanses have been popular in holistic centers for millennia. While juicing cleanses are potentiated by other holistic techniques, by themselves, as stand-alones, they can also be beneficial in terms of oxygenating, alkalinizing, detoxification and mineralizing the body’s tissues. Furthermore, the body’s conductivity also gets more intense. We may show this conductivity via an electrical experiment. (3 a).  Water and juice fasting should be preceded with other types of detoxification so that released toxins and toxicants can be removed in a more gentle way.

 What is the best “detox” water to Drink ? (Hydration,  Structured Water & Toxicants)

Humans are made up of around 80 percent water. Given water’s essential role in cleaning out trillions and trillions of cells from metabolic waste, toxins and toxicants and in being the body’s lifeblood, it is important to avoid dead and toxic water. In this presentation, we will look at different hydration techniques, including vibrant mountain Vitamin B-12 rich spring water as well as structured water.

Toxins and toxicants are particularly relevant because many heavy metals and deleterious chemicals hinder the proper functioning of mammaliam metabolism, the repair genes, the mitochondria energy system, the immune system, the thyroid, the messaging molecules (cytokines, hormones, neuropeptides, neurotransmitters etc), genes’ co-factors, the microbiota, the metabolic detox pathways and the like. Two of many examples, when BPA and other obesogens latch on insulin receptors, insulin resistance is promoted, that which sets the stage for diabetes and early death (Source) and all the more so that animal saturated fat is abundant and exercises deficient. When heavy metals are present, Lyme’s bacteria become much stronger. There are hundreds of examples of this nature, a few of which will be discussed in this talk as well as house detox protocols via house plants, hepa filters, ionizers and essential oils, organic paint, healthy building material, water purifiers and more.

The Myth of Drinking Lots of Water

Just like eating three meals a day is myth, so is drinking eight 8 ounce glasses of water a day, an official report has confirmed this piece of allegation. (Source) More than maintream medicine’s dictats, thirst should govern by the hydration “instinct”, even among the elderly. When  intense exercises, the steam room or a hot day come one’s way, the concerned person is usually thirsty and should drink to satiation quality water. As long as there’s a mostly plant based diet, it’s rare to be dehydrated. The best way to tell is by pinching the skin or looking at the urine. As long as one is not taking riboflavin (i.e., which fluoresces and turns your urine bright yellow), or ingesting beets, then the urine should be a light-colored yellow. The lighter, the cleaner the blood is.  Moderately yellow urine can be OK too, especially after a heavy meal. (Source) Based on the results from different studies, a healthy person urinates on average about seven or eight times a day. Depending on one’s glucose or toxicity intake,  urination can me more frequent. Drinking too much can put them people at risk of exercise-associated hyponatremia (EAH). In hyponatremia, the cells, including those in your brain, swell with too much water. (Source)

Some “Toxicant & Cellular garbage disposal” help from our Microbiota  Gluthatione-producing Friends

There’s a relatively unknown probiotic strain that was discovered in Europe in 1995 and that naturally boosts glutathione levels. Glutathione is a powerful antioxidants that has wide-spread effects in that every cells of our body needs it to protect  DNA from oxidative damage, among other functions. As a consequence, this ME-3 lactobacillus fermentum strain should be present in every living gut.

“There is much information about glutathione (GSH) in eukaryotic cells, but relatively little is known about GSH in prokaryotes. Without GSH and glutathione redox cycle lactic acid bacteria (LAB) cannot protect themselves against reactive oxygen species. Previously we have shown the presence of GSH in Lactobacillus fermentum ME-3 (DSM14241). Results of this study show that probiotic L. fermentum ME-3 contains both glutathione peroxidase and glutathione reductase. We also present that L. fermentum ME-3 can transport GSH from environment and synthesize GSH. This means that it is characterized by a complete glutathione system: synthesis, uptake and redox turnover ability that makes L. fermentum ME-3 a perfect protector against oxidative stress..…”. (Prikl Biokhim Mikrobiol. 2010 Sep-Oct;46(5):527-31.”Complete glutathione system in probiotic Lactobacillus fermentum ME-3” (Source))

As the Workshop presentation will show, Glutathione plays a crucial role in our antioxidant defenses and detoxification pathways. So making sure one’s gut has this L. fermentum ME-3 species is all the more important that human cells are often deficient in this molecule and supplements are not well absorbed.  Glutathione is not an essential nutrient to consume because our body naturally makes it from cysteine, glutamine and glycine, but because most humans are hit with an continuous onslaught of toxicants, optimizing this molecule is essential if the goal is to live healthy for 120 years and beyond.

Case Study A : Titanium Dioxide Nanoparticles (Link)

Case Study B: Lead, Candles and More (Link)

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Session E: Quality, Traditional & Moderate Wine intake extends Healthy Lifespans 

“Stop drinking only water, and use a little wine because of your stomach and your frequent illnesses.” 1 Timothy 5:23

The evidence the Presentation will share suggests that early death and multiple chronic diseases appear to be either partially or primarily the result of abstaining from this “essential nutrient” we call wine. But only if the dosage is “small to moderate”.

As Paracelsus said over two thousands years ago, “wine is a medicine, a food or a poison depending on the dosage”, to which we can add quality, pairing and timing. Too much wine will obviously harm the liver, the brain and other organs, but in the right proportion and context, wine can be a good medicine, just like essential oils, sunlight, exercises, heat, botanicals, caloric restriction, food, sound and the like. But for wine to be great medicine, it must be sipped holistically and its grapes and vinification should be prepared traditionally, (for that extra resveratrol boost) and without chemicals. Today, in the United States, the FDA allows Americans to drink wine that can have  up to 76 additives, including but not limited to arsenic, lead and glyphosate. (Source) And because the US government does not require labeling, the wine consumer should ascertain that the wine is organic and traditionally made.

In this presentation, we will examine a few diseases that quality wine can help to both control and reverse as well as its impact on longevity.

“Wine is a traditional beverage that has been associated with both healthy and harmful effects. Conceptions like the so-called “French paradox” or the beneficial impact of the Mediterranean diet suggest benefit. (…) there is reasonable unanimity in beneficial effects of moderate wine consumption in cardiovascular disease, diabetes, osteoporosis, maybe neurological diseases, and longevity”. (Source)

On the issue of “Moderate” versus “biologically indicated” quality wine

While a new published study has suggested that even moderate wine could be deleterious to the health, another recently published study has corroborated that low dosage of alcohol consumption in comparison to no alcohol or high alcohol consumption was beneficial for glymphatic function, meaning that the mammalian brain was better able to clear itself of harmful debris, which is key if one wants to avoid neurological diseases and dementia.

This Presentation will look at the built-in flaws and biases conventional, alternative and  vegan scientists use to unfairly and unscientifically condemn wine, even in moderate amounts. Wine in essence is dose-dependent medicine, so it’s a given that drinking too much is not healthy. But drinking cheap wine is also unhealthy, if only because American modern viticulture is one of the most  soil-disturbing and chemically sprayed (i.e. lots of cancer among conventional viticulture farmers, including eye cancers). On the other hand, and most American physicians miss this piece of ancestral wisdom, quality wine in the right amount and at the right time and under the right holistic conditions is royal (great) medicine, the evidence of which remains overwhelming for dozens and dozens of health conditions. We will thus share a few elements of French holistic wine protocols to help control and reverse diseases, including liver diseases and alcoholism.

Does One glass of Red Wine a day contain enough Live Chemistry for Longevity Benefits ?

Differently from a resveratrol supplement, wine’s resveratrol is bathed in a milieu that contains hundreds of other inter-active live molecules, all of which helps resveratrol to be well assimilated and to perform its therapeutic “magic”. A typical glass of red wine can contain anything between 250 micrograms and 1.5 milligrams of resveratrol. Its precise amount  depends on a number of variables, from the type of grape is used to make the wine, where the grape is grown, with  what agricultural method (organic grapes have more resveratrol that non organic or poor grown grapes), with what vinification procedure (traditional long fermentation boosts resveratrol content), how ripe the grape is when it’s harvested, how long the wine is aged for  before it’s drunk etc. Like with people, some wines age better than others.

In this Presentation, we will go into the details regarding the resveratrol question as well as with wine’s other polyphenols, flavonoids and hundreds of other beneficial substances, including live micro-organisms that fine-tune wine’s health and aging benefits, just like the human microbiota fine-tunes human healthy longevity.

Case Studies

In this section, we will examine couple cases where patients have been able to reverse their disease conditions just with wine. (Links)

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Session F: Is the Body’s Endocannabinoid System essential  insofar as general homeostasis, wellbeing & Longevity are concerned ?

“It’s not because we are old that we don’t play, it’s because we don’t play that we get old” (George Bernard Shaw)

The endocannabinoid system (ECS) is a newly discovered biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system. The endocannabinoid system is also involved in regulating a variety of physiological and cognitive processes including but not limited to general homeostasis and brain rejuvenation (neurogenesis). Likewise with cancer and over one hundred heath disorders.

“…cannabinoids may inhibit tumor growth by causing cell death, blocking cell growth, and blocking the development of blood vessels needed by tumors to grow. Laboratory and animal studies have shown that cannabinoids may be able to kill cancer cells while protecting normal cells”. (From the Federal Government’s National Cancer Institute) Source

In this Presentation, after a brief review of the endocannabinoid system (ECS) and one of its diseases officially called clinical cannabinoid deficiency disorder (CECD), we will look at a recent finding regarding cannabiniods’ role in optimal longevity. In this perspective researchers in 2017 confirmed that cannabinoids may be a forgotten essential nutrient, in particular for the elderly. Because levels of natural cannabinoids in the ECS decline with aging,   these researchers focused on the correlation between cannabinoids and memory and provided convincing evidence that the lack of cannabinoids is a proximate cause of the loss of memory function in later life. Medical marijuana has also  been shown to be beneficial for the elderly regarding pain management. (Source) We will also show that it is possible to stave off cognitive decline by using low doses of tetrahydrocannabinol to supplement endogenous cannabinoids. Likewise with Cannabis’ benefit effect with mitigating the United State’s hard alcohol and prescription opiate epidemics. Cannabinoids from different plants will also be reviewed in terms of their contribution to healthy lifespans, including, but not limited to different varieties of exotic peppers that also contain healing cannabinoids.

The Big Three C’s: Cannabinoids, Curcuminoids and Carotenoids

Given the entourage effect, synergy, homeostasis and other mechanisms that are inherent to the very engine of evolutionary biology, when we mix cannabinoids like CBDs, CBGs, CBNs, THCs, inter alia (among others) with other molecules coming from a living Rainbow-like diet full of luxuriant pigments and rich in polyphenols and phytochemicals like curcuminoids, carotenoids, terpenoids, peperine, myrcenes and other molecules, the synergistic combination of which potentiates multiple therapeutic effects. In this realm, combining organic black pepper to curcuminoids will also enhance their anti-inflammatory and antioxidants virtues, if only because curcuminoids’ bioavailability will increase by 2000 times.

 “For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%.” (Source)

The fact that black pepper is rich in cannabinoids suggest that the curcumin-cannabis combo would be a medically efficient pairing. Now when we add carotenoids, the therapeutic bang may be even more interesting, as we will see via power point. In this presentation, we will thus demonstrate how to benefit from therapeutic formulas that can help upregulate both happiness  and Longevity genes, as well as their neuropeptides and hormones.

Case study: Cannabinoids and Cancer

In this Section, we will examine a few cases where patients suffering from serious diseases and pain have successfully mitigated and reversed their diseased conditions with cannabinoids. (Links)

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 Session H: The French & Holistic Approach to Health & Optimal Longevity

“The fixity of the milieu supposes a perfection of the organism such that the external variations are at each instant compensated for and equilibrated. Therefore, far from being indifferent to the external world, the higher animal is on the contrary constrained in a close and responsive relation with it, of such fashion that its equilibrium results from a continuous and delicate compensation established as if by the most sensitive of balances.” (Professeur Claude Bernard)

In France, much of medicine reflects the culture of the “le juste milieu”, the Goldylock “right balance”. As a consequence, half of French medical doctors practice homeopathy while the vast majority of them will prescribe lifestyle “joie de vivre” medicine, whether it be via the famous three weeks (per year) Government paid health spa vacation in one of France’s sunny resorts and-or other modality, some of which include thermal therapy, wine medicine, leisure,  homeopathy and  multiple destressing techniques like sophrology, aromatherapy, phytotherapy, or, among other integrative and holistic techniques, healthy flavorful and uplifting food, spices and herbs, what is officially called clinical nutritional medicine, all in the “right balance” within a rich bio-diversity “entourage” and enjoyable milieu.

“Instead they offer a holistic approach to alleviating chronic conditions such as arthritis and multiple sclerosis. As well as bathing, curistes drink 10 tiny glasses a day of the mineral rich water. To me, the water tasted rather salty. One man I spoke to said it kept him awake at night.  But most feel it helps, as do the massage, gymnastics and lessons in cooking healthy food that are also on offer. Between now and October, thousands of curistes – drawn mostly from France’s retired population – will spend up to three weeks floating and gossiping in the hot pools.  The spas are set in beautiful gardens and staffed by doctors, physiotherapists and dieticians… all of which comes at a hefty price. Most can only afford it because the bill is footed by the State. (…) (Source)

In this presentation, we will define the hippocratic-based French approach to medicine, food and public health and briefly show a few of  its strengths, some of which could benefit the American health-care system.  (6 b)

Joie de Vivre, French Cuisine & Tradition

In the “crudités” part of French Mediterranean meals, flavor and esthetics are combined with rainbow colors. Each color, made from different plant pigments, is endowed with rich and complex phytonutrients and polyphenols that target specific metabolic pathways. Anthocyanins, pygnogenol and resveratrol for example all help activate the longevity sirtuin genes, inter alia.

In this presentation, we will review a few French Mediterranean “super-foods” and dishes, including, but not limited to fruit, flower, veggie, grains, roots and the herb Kingdom as well as fungi from the mushroom kingdom and friendly bacteria, all of which can help to avoid and even treat chronic diseases while activating longevity and “happiness” genes.

Case Study A: French Homeopathy: Science, Wishful Thinking or Witchcraft  ? (Link)

Case Study B: Auriculotherapy (Ear Acupuncture): French Quakery, Chinese pseudoscience or evidence-based Medicine ? (Link)

Case Study C: Acupuncture and Longevity Optimization (Link)

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Lunch Break: Session I: Culinary Remedies, Longevity Smoothies, Essential Oils & Wine Demonstration

“Wine can be a poison, a food or a medicine depending on  the dosage” Paracelsus

In this Kitchen Demonstration, we will demonstrate how to optimize certain foods (using plants, herbs, flowers, roots, essential oils, mushrooms and the like) via the making of a longevity dish (Smoothie, soup or the like) that comes from either the Mediterranean Diet, the Vegan Diet and-or the Rawfood Whole-Plant diet. Concomitantly, we will demonstrate how wine is used medicinally. As we work on our  Demonstrations, the workshopees are free to munch on their own lunch.

Hormonal balancing

After-Lunch Meditation Exercise

Session J: Bio-Physics, Photons, Helio-therapy & inter-cellular Communication, Electro-acupuncture & TCM

“We are still on the threshold of fully understanding the complex relationship between light and life, but we can now say emphatically, that the function of our entire metabolism is dependent on light.” Dr. Fritz Albert Popp

As the mitochondria’s integrity erodes with time and entropy, there tends to be a cellular upheavel in the production of ATP, ROS and over-all inter-cellular communication. One of the consequences of this process is sarcopenia, the loss of muscles and bone density, a condition that leads  femoral and hip fractures among the elderly. Is this condition the result of a natural old age process or the result of impaired thinking ? Can Sun therapy (in Europe, this medicine is called “heliotherapy”, from the Greek “helio”, which means Sun), acupuncture, bio-photons, bio-electricity and a holistic lifestyle help to overcome sarcopenia, bone loss, brain atrophy and accelerated aging ?

“Biophotons may represent a complex cell-to-cell communication that relies upon speed of light transmission. The physics of light seems to fit the biological observations. Light is the most efficient and fastest mediator of information in the world. The coherent property of biophotons may have a profound effect on their ability to influence information transfer. Frequency coding gives light a capability of encoding information from DNA in biophotons. (Source)

While biophysics and longevity research is still nascent and unsettled, we already have emerging evidence that bio-electricity and photons may have an important role in health and longevity including on inter-cellular communication and the mitochondria, whose degradation is one of the aging hallmarks we have examined.

“In recent years, a growing body of evidence shows that photons play an important role in the basic functioning of cells. Most of this evidence comes from turning the lights off and counting the number of photons that cells produce. It turns out, much to many people’s surprise, that many cells, perhaps even most, emit light as they work. In fact, it looks very much as if many cells use light to communicate. There’s certainly evidence that bacteria, plants and even kidney cells communicate in this way”. (From M.I.T. Source)

In this presentation, we will show what the evidence suggests with regard to the role of photons on the mitochondria and inter-cellular communication. Bio-electricity and particle-wave medicine, from electro-acupunture to Pemf, low dose radiation, TENS, Sound frequencies and more all appear to favorably mitigate chronic diseases and modulate longevity pathways inc .

Case Study: Cell Phone Radiation & EMFs Toxicity (Link)

Acu-pressure, traditional Oriental Medicine, Yoga workshop.

Addressing Systemic Inflammation and inter-cellular Communication

As mammalian cells divide and transform into senescent cells, their communication with other cells becomes dysfunctional leading to an increase in chronic inflammatory distress signals and misfiring of hormonal and neurotransmitter messaging. As a consequence thereto, neuropeptides and hormonal signaling go haywire. For example, the aging hypothalamus changes neurohormone signals, which in turn affects food intake and metabolism. Since the hypothalamus also regulates sleep cycles, these changes can perturb sleep, inhibit DNA repair and, inter alia, accelerating aging even further.

All in all, there is more and more compelling evidence that aging is not an exclusively cell biological phenomenon and that it is coupled to a general alteration in intercellular communication as well as environmental factors including, but not limited to “fields”. Proof of principle already exists for rejuvenation through blood-borne systemic factors (Conboy et al., 2005; Loffredo et al., 2013; Villeda et al., 2011).

In this Presentation, we will look at what we can do as humans to both clean-up, cool-down and tune-up the inter-cellular communication network. It’s a bit like public international law. For the inter-state system to avoid war, diseases and function smoothly,  norms need to unite more than they divide and erode. While the inflammation cascade is beneficial under precise conditions, inflammation that accompanies chronic diseases is not, even slow mild inflamation is deleterious and damaged the inter-cellular network. There are dozens of plants and molecules that are effective in downregulating inflammation, from turmeric, frankincense, mushrooms and many plants.

Modified Citrus Pectin and Inflammation.

Found in the pith of citrus fruit peels, modified citrus pectin (MCP) has been shown to inactivate galectin-3, blocking its ability to send destructive inflammatory molecular signals throughout the body. (Cf 4Kolatsi-Joannou M, Price KL, Winyard PJ, Long DA. Modified citrus pectin reduces galectin-3 expression and disease severity in experimental acute kidney injury. PLoS One. 2011;6(4))

Because of its ability to block galectin-3, modified citrus pectin is emerging as a key natural compound for chronic diseases and longevity. This supplement is popular in the Integrative and Holistic Oncology world.

Case Studies: Addressing diseases with Frequency & Electro-medicine & TCM: Brain Cancer and more (Links).

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Session K: Dental Holistic Care & how the Conventional Toxic Dentistry System impedes Americans fr reaching healthy Lifespans

Because the present conventional dentistry standards of care are connected to chronic diseases and accelerated aging, this talk will review some of the key holistic measures that can avoid toxic dentistry, including but not limited to healing early-mid cavity decay with holistic savoir-faire techniques, detoxing via oil pulling, home-made essential oil mouthwash, safe mercury-amalgam removal protocols, biocompatible dental material, avoiding endocrine disrupting leaching chemicals like BPA from different dental components (e.g., including, but not limited to BPA sealants, if only because it has been shown that BPA can lead to autoimmune diseases), using ozone, lasers that can replace the “drill & fill” technique and more. Implants with one’s own dental stem cells is already operational, but the conventional dentistry system is hindering it’s full clinical availability while the Government’s NIH experts still refuse to finance studies on mercury’s devastating health effects, all of which are fully supported by hard evidence from hundreds of peer reviewed studies that can be found in the international scientific literature.

Given the US’s peridontal infection epidemic (over 65 percent of teeth loss is due to gum disease and over 90 percent of Americans have some form of gum disease) as well as the toxic heavy metal poisoning pandemic (including, but not limited to mercury and industrial fluoride), the root canal aberration (i.e. leaving a dead tooth in the body is medically insane), avoidable cavitations, galvo-currents and more, biological and holistic dentistry is a necessary tool to consider if the workshopee is serious about optimizing a healthy lifespans to 120 year and beyond. Likewise with new technologies like laser and 3 D cone beam scans that can detect serious infections and tooth abcesses that digital scans and x-rays miss. This Presentation will included case studies of cancer and cardiac cases being resolved once dental problems were holistically fixed.

On the Horizon: Dental stem cells

As mentioned above, natural implants that come from one’s own dental stem cells have already been successful with animals and humans via clinical trials, therefore in theory, this procedure is operational, but not yet accessible. In addition to the fine-tuning of scaffolds and growth factors, there is Bureaucracy. Meanwhile, stem cell research continues and now, the expert scientists are telling us that some time in the not too distant future, we will be able to use our own dental stem cells to regenerate non dental tissues, from heart tissue to hepatic, renal and more.

“.…Dental stem cells (DSCs) have a remarkable self-renewal capacity and multidifferentiation potential; DSCs are extremely accessible and prevail during all life; DSCs, as stem cells therapies, have shown amazing therapeutic abilities in oro-facial, neurologic, corneal, cardiovascular, hepatic, diabetic, renal, muscular dystrophy and autoimmune conditions; DSCs are becoming extremely relevant in tissue engineering and regenerative medicine” (Source).

There are already a different global services that will store fallen teeth for future regenerative use. For now, the focus is a child’s baby tooth, as they have the most potent stem cells, especially in wisdom teeth. See:  Store-A-Tooth. From what i understant, these companies partner with one’s dentist to collect the tooth and have it shipped overnight to their facility in a temperature-controlled kit. Once the tooth is in their hands, they extract the stem cells and place them in a culture where they can grow. Then, the cells,  along with the tooth,  are cryopreserved. The price is hefty. And there is no guarantee that in 20 years, these stem cells will still be potent.

Aromatherapy: for oral cavity and body health

Aromatherapy is one of many holistic dental techniques. French-invented, modern aromatherapy (founded by René-Maurice Gottefaussé & Vanet) has been taught in France for over a century, thanks to which we now know how to best use plant volatile essential oils and their blends for the optimization of the oral cavity, mood, detox, immune-boosting and many other conditions and diseases via their incorporation in water, food, air, land (as natural insecticides), massage, suppository and, among other modalities, intravenously and via mouthwash, in particular cloves essential oil whose eugenol compound helps to both numb tooth pain and remove deleterious bacteria. In this Presentation, we will review of few of the key essential oils that can be useful for healthy extended lifespans.

Case study: The link between the Oral Cavity and Chronic Diseases (Cancer, CVDs and others) (Link)

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Session L: The Reversal of Alzheimer’s Disease & Depression with Holistic Savoir-Faire

“In investigating nature you will do well to bear ever in mind that in every question there is the truth, whatever our notions may be. This seems, perhaps, a very simple consideration, yet it is strange how often it seems to be disregarded. I remember at an early period of my own life showing to a man of high reputation as a teacher some matters which I happened to have observed. And I was very much struck and grieved to find that, while all the facts lay equally clear before him, those only which squared with his previous theories seemed to affect his organs of vision.” (Lister)

It remains impossible to achieve a healthy 120 years, let alone JDV when serious mental and neurological disorders like Azheimer’s Disease (AD), Parkinson, Depression or M.S. hit. In the U.S., Alzheimer’s Disease incidence will triple to what it is today. In England, where holistic lifestyle has not been well rooted, AD has replaced both cancer and CVD as the number one killer and the US is not far behind, at least for the elderly. For those with the APOE 4 gene, the risk factors are higher and strike earlier.

Conventional Medicine neurological experts, just like in the cancer, cardiovascular and most other chronic disease fields, have blindly postulated that the major culprit is a symptom or group of symptoms that drives the disease. In this case, the central hallmark of AD. has been conventionally determined to be  the beta amyloid plaque, a form of misfolded proteins. After over 30 years and billions of dollars testing drugs in clinical trials, not one of these anti amyloidal drugs made a difference in terms of safely and efficiently treating this disease. (The amyloid plaque did shrink with some of these drugs but from the viewpoint of even delaying the Alzheimer’s process, these lab molecules failed. And they will continue to fail because their approach is symptomatic).

In this Presentation, we will show via documened power point that holistic scientists and neurologists have proven beyond any reasonable doubt, that amyloid plaque is a mere symptom, not the cause of Alzheimer’s Disease, just like high blood pressure is an adaptive and compensatory symptom of being in a very high altitude area. Furthermore, we can demonstreate that the amyloid plaque, just like the arterial and dental plaques, is a defense mechanism against other deeper causes that conventional medicine misses or refuses to investigate.

For over twenty years now, we have known that the so called “Alzheimer Disease hallmark”, the amyloidal plaques as the driver of the disease, is a dogma. Below, a 2004 piece from a group of scientists who are not fooled by conventional medicine’s approach.

“Ever since their initial description over a century ago, senile plaques and their major protein component, amyloid-beta, have been considered key contributors to the pathogenesis of Alzheimer disease. However, counter to the popular view that amyloid-beta represents an initiator of disease pathogenesis, we herein challenge dogma and propose that amyloid-beta occurs secondary to neuronal stress and, rather than causing cell death, functions as a protective adaptation to the disease….”. By analogy, individuals suffering from altitude sickness nearly always have elevated levels of hemoglobin. However, while hemoglobin is toxic to cells in culture and increased erythropoiesis at sea level can be deadly, it is clear that the increases in hemoglobin occurring at altitude are beneficial. Amyloid, like hemoglobin, may also be beneficial, in this case, following neuronal stress or disease. Although controversial, a protective function for amyloid-beta is supported by all of the available literature to date and also explains why many aged individuals, despite the presence of high numbers of senile plaques, show little or no cognitive decline. With this in mind, we suspect that current therapeutic efforts targeted toward lowering amyloid-beta production or removal of deposited amyloid-beta will only serve to exacerbate the disease process. (Ann N Y Acad Sci. 2004 Jun;1019:1-4). (Source)

Below, another piece of published evidence from 2002, wherein the authors show that both amyloid-beta and tau, the major components of senile plaques and neurofibrillary tangles, are less the central mediators of the pathogenesis of Alzheimer disease than protectors from upstream biochemical events, including, but not limited to oxidative stress.

“… in light of recent evidence, such “lesion-centric” approaches look to be inappropriate. In fact, rather than initiators of disease pathogenesis, the lesions occur consequent to oxidative stress and function as a primary line of antioxidant defense. (…) The notion that amyloid-beta and tau function as protective components brings into serious question the rationale of current therapeutic efforts targeted toward lesion removal”. Free Radic Biol Med. 2002 Nov 1;33(9):1194-9 (Source)

In clear, as we will see in this power point presentation, the brain’s innate intelligence puts in place defense mechanisms (in the form of amyloid-beta and tau proteins) in order to mitigate the assaults of toxins, allopathic drugs and heavy metals, including loads of mercury that are still systematically placed right under the brain, in the oral cavity’s teeth where mercury vapors are able to cross the blood brain barrier and accumulate therein

In this Presentation, we will thus show how to avoid Alzheimer’s as well as other neurological risks by over 90 percent. Reversal of most of these mental disorders has also been established, including for Alzheimer’s Disease via different holistic protocols, some of which we will examine.

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Detecting Alzheimer’s disease many years before symptomatology by looking at the Eye

Alzheimer’s disease (AD) develops undetected for many years due to the lack of early diagnostic biomarkers. In advanced AD, visual deficits related to cortical neurodegeneration are have been recognized. Recent recent studies have moreover identified that the retina could be affected prior to the Alzheimer attack on vulnerable brain areas such as cortex and hippocampus.

“Translation of these findings to clinical diagnosis could lead to earlier therapeutic interventions and, consequently, better chances to delay or halt AD progression”. (Curr Alzheimer Res. 2017;14(1):6-17)

In this above-mentioned meta analysis, a total of 134 papers were included in the review, the majority  dealing with the earliest dysfunction of synaptic and neuronal networks in vulnerable brain areas. The researchers found evidence  in 11 papers indicating why putative retinal synaptic dysfunction holds the potential to become the earliest sign of AD, allowing for a non-invasive and easy detection using modern imaging and functional techniques. Iridology also claims to be able to detect Alzheimer’s disease just by looking in the iris. But these claims appear to be contorversial. We will look into this deeper.

 Having APOE4 gene significantly ups Alzheimer’s Risk.  Holistic Techniques can remove these Risks

The APOE protein carries cholesterol and other fats through the blood. If we eat a high-fat diet, our bodies make more APOE. APOE is also found in the brain. It’s important for brain development and repair of brain structures after injury or inflammation (Source) This protein is encoded thanks to the APOE gene.

There are three major variations (alleles) of the APOE gene called APOE2, APOE3 and APOE4. We are each born with two alleles at the APOE gene and can have any combination of the three different alleles. For example, we could have E2/E2; E2/E3; E3/E3, E and so on.

These APOE gene alleles produce different forms of the protein Apolipoprotein E. Studies indicate those with the APOE4 allele are significantly more likely to get late-onset Alzheimer’s disease than others. Those with two copies of the APOE4 allele are at even greater risk.(Source) Having the APOE4 allele does not mean a person will definitely develop Alzheimer’s,  it just significantly increases the likelihood of acquiring not only AD, but also other forms of Dementia and CVDs.

On the other hand, the APOE2 is protective, especially in terms of longevity. In the general population in Europe / USA, roughly 75% of people are APOE3/3, and the APOE3/4 or 4/4 variants are present in 20 – 25 % of Westerners.

The most cost effective way to find what genes one has is through 23andMe company. (Source) See below in the Monitor tests for details. In this Presentation, we will show via power point how to significantly disarm APEO4 via holistic medicine.

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Movement  attenuates the deleterious effects of APOE4 & all other chronic diseases while boosting Telomeres, HGH & DHEA

Drawing from neuroscience, anthropology, and brain-imaging research, scientists have shown that the evolution of increased physical activity “…approximately 2 million years ago served to reduce the amyloid plaque and vascular burden of APOE ɛ4, relaxing genetic constraints on aging”(Source) Furthermore, in 2009, after Biochemistry Professor Elizabeth Blackburn discovered that the enzyme telomerase has the ability to lengthen the telomere (and won a Nobel Prize for her efforts), the following year, scientists showed that exercise mitigates the effect of chronic stress on telomere length. (Source) Complementary studies also found a reduction of telomere shortening when the elderly practiced high-intensity-type exercises. (Source)

Numerous other studies have shown that maintaining a minimum quantity and quality of exercise decreases the risk of death, prevents the development of certain cancers, lowers the risk of osteoporosis and increases longevity. Even daily walks helps. (Source), as well as ritual-exercises like Chi Gong, Tai Chi, Tibetan stances and Yoga. One study showed that daily yoga practice is linked to an increase in two key substances linked to youth and longevity: Growth hormone (GH or somatotropin), a peptide hormone and dehydroepiandrosterone sulphate (DHEAS), a key longevity androgen hormone. (Source)

Thus, everyone can benefit from exercises, especially ALzheimer and Chronic disease patients as well as those who are making efforts to reach 120 years.  In this Presentation, we will look a the supporting evidence as well as a few key longevity exercises, including the Tibetan ones.

Case Study: Reversing Alzheimer’s Disease with Holistic Medicine (Link)

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Depression and Holistic Medicine

Similarly, depression is less the result of a deficiency of psychotropic drugs than an inflammatory condition associated with neuro-transmitter imbalances, toxemia, lack of quality sleep and and other related factors. Because inflammation is greatly modulated by the immune system and the gut, holistic healers and teachers first address gut dysbiosis, then look at the immune system and finally the bain’s neuro-plasticity (which includes the nerve growth factor) and even neuro-genesis.

Diet, exercises (important to stave off depression), heliotherapy, meditation, massage, acupuncture and a few supplements are some of the healing tools Holistic practitioners use. Often, cancer patients who are zonked with radiation and chemo have their protein reserves decimated. Hence, healthy plant-based and fiber-strong nutrition with an abundance   of dark greens and quality fatty acids (most of the brain and cells membranes are made from fat) is key. And lots of vitamins, minerals, flavonoids and polyphenols are also helpful. For quick relief, acu-pressure, oxygenation via exercises and thermal detox are recommended as well as certain nutraceuticals (dietary supplements) like St John’s Wort, magnesium, curcumin,  mitochondrial boosters, drug-free regime (ie, tylenol for example eventually harms both the mitochondria and kidneys), acytel-choline, mushrooms, cafeine, omega 3, BDNF nutrients, cannabinoids, L-theanine from green tea, lavander essential oil (the Germans have a powerful one in capsules) and a few others. L-theanine with or without CBD cannabinoids can help to foster spiritual alertness and mental clarity, analagous to having a zen meditative state. Meditating and having some green organic tea with L-theanine and-or light roasted (or green infused) organic coffee can also be beneficial as is yoga and most everything else that is holistically restorative, including sleep of course. This Presentation will thus review a few evidence-supporting slides.

Case Study A : Depression and Gut Disorders (Link)

“Here we provide evidence that psychological stress— both perceived stress and chronicity of stress—is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells from healthy premenopausal women. Women with the highest levels of perceived stress have telomeres shorter on average by the equivalent of at least one decade of additional aging compared to low stress women”. (Source)

Case Study B :  Depression, stress and meditation (Link)

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Session M: The Microbiota Revolution in Medicine & how Microbiome Medicine Optimizes Longevity

Since 2012 when the Journal Nature published the Human Microbiome Project’s (HMP) results, the very face of medicine has changed. With 8 million Microbiota genes that cross talk with our 22,000 (or 23K) human eukaryotic genes, we better understand the Microbiota’s pivotal role with regard to physiology, diseases and longevity, all thanks to our inner Garden’s critters made from bacteria, virus, fungi, archaea and, inter alia, their genes.

“The human body contains trillions of microorganisms — outnumbering human cells by 10 to 1. Because of their small size, however, microorganisms make up only about 1 to 3 percent of the body’s mass (in a 200-pound adult, that’s 2 to 6 pounds of bacteria), but play a vital role in human health (…) Researchers now calculate that more than 10,000 microbial species occupy the human ecosystem. Moreover, researchers calculate that they have identified between 81 and 99 percent of all microorganismal genera in healthy adults (….) HMP researchers also reported that this plethora of microbes contribute more genes responsible for human survival than humans contribute. Where the human genome carries some 22,000 protein-coding genes, researchers estimate that the human microbiome contributes some 8 million unique protein-coding genes or 360 times more bacterial genes than human genes. This bacterial genomic contribution is critical for human survival. Genes carried by bacteria in the gastro-intestinal tract, for example, allow humans to digest foods and absorb nutrients that otherwise would be unavailable. (Source)

These discoveries on the microbiota have been shown to be useful for the control and reversal of not only  Alzheimer’s disease, but for auto-immune diseases, diabetes, cardiovascular issues, cancer and more. The evidence confirms that both the microbiota and the microbiome impact the expression  of our entire genetic Code in multiple ways.  In addition, the microbiota makes many of our key nutrients and molecules, from the vitamins K and B6, to neuropeptides like serotonin and dopamine that affects our neurochemistry, to short chain fatty acids, to the protection of the gut lining, the promotion of signaling molecules, the downregulation of inflammation and more.

In this Presentation, we will look at a few of these discoveries and show how human Lifespan can be extended with the use of a holistic lifestype and diet that includes certain probiotics, probiotics and superfoods that favor certain key gut bacteria that inhabit healthy centenarians, most of whom harbor a microbiota as rich and diverse as those of thirty years old.

Microbiota Dysbiosis

As we will see, the very same bacteria who have been so essential in the complexification of Life over the last 65 millions of years are living in our guts churning away to make us either sick and short lived or healthy and long lived. For example, supercentenarians have a diversed amount of youthful bacteria whereas sick people who die young have lots of dysbiosis and poor diversity. Microbiome science has been one of the most recent scientific revolutions in Medicine, disproving a big chunk of mainstream medical dogmas. In this Presentation, we will also look at binderswhat hinders the optimization of the microbiota’s robustness and diversity.

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Case study A: The Microbiota, Genes and Colon Cancer: Do Human eukaryotic genes cross-talk with Bacterial Genes ?

As we have seen and will see again one of the superhero Longevity Gene is the old (billion years old) Sirtiun 3 who has multiple roles in homeostasis and longevity. When it is well expressed, it talks with different species of human microbiota whose Sirtuin 2 genes resonate with human eukariotic Sirtuine 3 genes. In other words, they cross talk to figure out what is the best evolutionary strategy is regarding growing colon cells in the very gut that these genes reside. Crosstalking between gut microbiota and Sirtuin-3 in colonic inflammation and tumorigenesis  and the subsequent anti-inflammatory and tumor-suppressing tactics that are put in place with the Bacterial allies is less delusionary than real, anchored in biology, but not in the FDA data-banks.

“The key microbes that prevent downregulation of Sirt3 expression during colorectal tumorigenesis are L. reuteri and L. taiwanensis, which may provide a precise therapeutic strategy for the prevention of Sirt3-deficient colon cancer by manipulation of the gut microbiome… Moreover, Sirt3 and commensal microbiota synergize to regulate the expression of CLCN4 in the development of colon cancer…Considering the gut probiotic effect of SIRT3KO mice, it is possible that probiotic bacteria, such as Lactobacillus, may provide bacterial Sir2 (a gene was homologous to eukaryotic Sirt3) for deacetylase activity. A previous in vitro experiment demonstrated that bacterial Sir2 activity is elevated with co-culture of Lactobacillus acidophilus and Caco-2 cells (Source) Thus, Sirt3 may be crucial for a probiotic effect in gut tumorigenesis. In conclusion, Sirt3 is a novel colonic tumor suppressor that inhibits colonic tumorigenesis via an interaction with the gut microbiome”. (Source)

In this Presentation, we will look a little deeper at how the microbiota’ s genes and our own genes collaborate to remove cancer cells. But there’s a caveat. Human genes can also be hijacked by Microbiota genes to spread cancer thereby shorten longevity. The macriobiota can even block conventional oncology’s weapons of mass cellular destruction. Which may be a good thing, but Big Pharma & the FDA do not agree. The Key issue then is under which holistic conditions can we coordinate  human and bacterial genes to optimize cancer-free longevity ?

Case B: Are the Gut’s Bacteria capable of Detoxify human chemicals while favorably modulating ROS ?

One of the difference between Holistic Medicine and Conventional Medicine is that the Government’s medicine is based on ignorance, greed and war via weapons of cellular mass destruction, inter alia, while Holistic medicine is based on knowledge, (including the highest form, intuitive knowledge, the one Einstein used), generosity and peace, in particular via the harmonization of all of the constituent members of this thing called Life. So not only is the microbiota capable of removing the Government sponsored corporate chemicals that assail Life, including most, perhaps 99 percent of Conventional Oncology’s cytotoxic chemo (hence the epiphenomenon called chemo resistance), but it is also capable of producing its own Number One detoxifier molecule, the great Glutathione. Futhermore Glutathione helps with modulating ROS and since ROS is a factor in aging, we have a win win situation where  certain species of bacteria will both reduce ROS and activate the detox pathways. At least if the Government’s medicine stops spreading it’s chemical poisons tous azimuths.

There is much information about glutathione (GSH) in eukaryotic cells, but relatively little is known about GSH in prokaryotes. Without GSH and glutathione redox cycle lactic acid bacteria (LAB) cannot protect themselves against reactive oxygen species. Previously we have shown the presence of GSH in Lactobacillus fermentum ME-3 (DSM14241). Results of this study show that probiotic L. fermentum ME-3 contains both glutathione peroxidase and glutathione reductase. We also present that L. fermentum ME-3 can transport GSH from environment and synthesize GSH. This means that it is characterized by a complete glutathione system: synthesis, uptake and redox turnover ability that makes L. fermentum ME-3 a perfect protector against oxidative stress. “ (Source)

Case Study C: The Gut microbiata via fecal transplants and the reversal of multiple diseases

If time allows, we will also examine fecal transplants and how they have been successful with autism, obesity, colitis, infections and other diseases than hinder the 120 years reach.

Should Stool testing be part of all Diagnosis Work-ups ?

Given the importance of the microbiota as both factors and indicators of diseases, ordering a stool test should be part of the standard of care. In this presentation, we will identify simple methods that everyone can put in place in order to determine some of what stools indicate, in particular, in terms of smell, looks, texture and micro-organisms composition and their endotoxins and metabolites.

Screen Shot 2018-06-02 at 3.17.15 AM Session N: Holistic Nutrition, Gastroenterology, Weight Management & Diabetes

The Internet, bookstores and libraries are replete with nutritional claims that are often contradictory and scientifically spinned or biased, including, but not limited to dash-paleo-keto high-fat, mid-animal proteins, low-carb, high-calorie schools diets which tend to be inflammatory and deleterious for long term health and longervity.

On the other hand, anti-inflammatory plant-based, high fiber, high bitters, mid vegan fats, low protein, low calorie and high low-glycemic carbs ancestral diets tend to avoid chronic diseases and optimize longevity, including the mostly plant-based Mediteranean diet, as long as this diet has a low amount of clean quality animal foods, including raw organic honey and wild small clean fish (ie, Smash). But diets that include more than 5 percent animal foods (depending on the person’s gene pool) and-or have loads of processed foods tend to be deleteriously inflammatory and, inter alia, toxic to human kidneys, the endothelium and overall health. (9)  In other words, as Michael Polene put it, the available evidence suggests that Evolutionary Biology formed humans to be “mostly plant-based” eating fresh, whole and clean foods. In this Presentation, we will dive deep into the compelling evidence that proves beyond any reasonable doubt which diet is the best for which group of people..

The Paleo-Keto-Mediterranean-Vegan-Caloric Restriction-Diet Variation” Debate

What is the Best Diet for Energy Production, Memory Maintenance, Hormonal Optimization, Tissue & DNA repair, immune-enhancement and Cancer-Free Long Lifespans to 120 Years  that is also good for the Planet ?

Because Food is an important human element in both healthy lifespan protocols and sensory gratifying pleasures called “table pleasures” in French, which, for many, has become a religion, we will delve into this question with an added layer of rigor. For now, having reviewed the available scientific litterature, the facts suggest that the ideal human longevity diet is not consistent with the most popular diets in the US. In other words, this “ideal nutritional regime” is neither vegan, nor vegetarian, nor keto nor paleo nor compatabile with the Standard American Diet, let alone the insectivore diet.

While both the modern Paleo and Keto diets appear to be improvements over the over the 40,000 years old Neanderthal diets and the government’s GMO-based SAD (ie SAD = Standard American Diet), the facts show that both keto and paleo low-carb diets are not long term sustainable even if  they can be efficient for blood sugar control, weight management and a few other conditions (including epilepsy and  brain cancer with regard to a low protein restricted ketogenic diet).

In this Presentation, we will  show the compelling evidence that supports the best “across the board” nutrition plans that are consistent with the general principles of the Science of Optimal Longevity, the Engine of evolutionary biology and gastroenterology.

The Second part of this Discussion will go into specific and customized or personalized dietary recommendations according to different categories of adults, geographical differences and genetic variabilities. We will also look at some of the most popular American diets (e.g., the Zone Diet, Macrobiotic Diet, Dash & Sibo diets, the Low-Carb Diets (Keto or Ketogenic Diet, Atkins Diet, South Beach Diet, The Whole 30 Diet), pesca-vegetarian diet, veganism, Gerson and Hippocrates Institute diets etc) and identify both their strong and weak aspects.

Case Study A on the Keto and Paleo Diets (Link)

An effective recipe to die crippled with an onslaught of chronic diseases

The worse scenario in terms of insulin resistance and the onset of diabetes and CVDs is to ingest refined carbs, toxicants like BPa and an abundance of fats, especially animal and saturated fats. When the nutrition is adpated to human needs, insulin, which is one of the most anabolic hormones humans have, is beneficial to get not only blood sugar into tissues, but also amino and fatty acides. And glycogen (stored glucose in the liver) is needed for quick energy release, including during exerices and “fight & flight” episodes. Futhermore, the brain functions better on glucose than ketones, even if ketones can be an emergency fuel. While Drs Hymans and Mercola’s allegation that ketones are cleaner “fuels”  (in terms of ROS production) is not completely wrong, this claim is nonetheless misleading, if only because without enough healthy carbs and fibers, the body does not get to make enough of the good ROS the body needs, inter alia, the microbiota does not thrive as it should and multiple chronic diseases as well as accelerated aging creep in mid to long term.

This presentation will go into the details and show, with a preponderance of the evidence, that both the keto and paleo diets are not consistent with human optimal longevity. Maybe with dogs, as they can eat tons of animal cholesterol-laden meat and have impeccable endothelium, but humans can’t, with animal cholesterol and satruated fat rich foods, their arterial inner lining get clogged up as do their insulin receptors. A recent case in point is the ongoing President of the American Heart association who recently got hit with a heart attack at the age of 52. When we mix refined carbs with animal foods in the same meal, their saturated fats, in conjunction with deleterious chemicals, inter alia, compromise the entire insulin and blood stabilization machinery, as a result blood sugar spikes, insulin becomes resistant, it can’t activate the glucose transport pathway and the arteries get messed up to the point where thrombosis and heart attacks are likely. The evidence shows that even whole-food carbs like bananas can be a problem when high glycemic foods are synergiezed with animal fat in the same meal. To optimize healthy lifespans, workshopees  should first learn about holitic cardiology, chronobiology and the Med-diet.

Case Study B on Reversing Diabetes Holistically (Link)

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 Happiness Medicine Institute’s Holistic Mediterranean Diet & Executive Recommendations

“He will not look upon the rivers, the streams flowing with honey and curds”. Job 20:17

The Holistic Mediterranean Diet is an improvement over the classical Med-Diet in that it upregulates and improves the expression of thousands of genes while diversifying the microbiota like no drug or other diet can. For many decades, the prevailing evidence had determined that theclassical South European Mediterranean Diet has been the best human longevity diet. Thousands of published papers in the best peer-reviewed journals corroborate this piece of allegation. Even the controversial Ancel Keys ended up adopting the Med Diet by moving to South Europe where he  lived with his wife in decent shape until he reached 100 years. (Source)  The French version of this classical Italo-Greek Diet is what super-longevity champion Jeanne Calment thrived on until 122 and a half years.

Out of over a dozen Mediterranean versions of the Med-Diet, the Hapiness Medicine Institute’s Holistic Medicterranean Diet has fine-tuned this nutritional regime by taken the best of all of these Med-diet versions, from the Med-diet of Kosher Israel, to the mint-humus Med-diet of Morocco, Lebanon, Spain, Turkey, Icaria, Italy, Corsica, Croatia, Slovenia and more while improving it in light of new scientific discoveries, daring medical hypotheses and intuitive guidance.

In this Presentation, we will thus prove beyond any reasonable doubt that the Happiness Medicine Institute’s Holistic Med-Diet is clinically and nutritionaly superior to all other diets, in particular with regard to chronic diseases and TMAO avoidance, energy production, diversity of the microbiota and longevity optimization.

Case Study A: The Joie de Vivre French Approach to Food & the Art of Slow Eating (Link)

Case Study B: The Doctrine of Signatures (Teleological Nutritional Targeting) (Link)

Case Study  C:  Soy & Health (Link)

Case Study D: Can Quality A2 Traditional-made Cheese be a Longevity and Medical Food ? (Link)

Case Study E: The French Paradox on the High Cholesterol & Low CVDs

Wine as medicine workshop

Top:  In France, Cheese is prefered raw and organic, from grass fed animals, without antibiotics and artificial hormones and combined with wine. Although cow cheese is cheaper, most of the French prefer sheep and goats cheese, if only because these cheese have healthier casein protein and lipid profile than cow cheese, hence the gusto-olfactory contentment.  As an accompaniment, polyphenol-rich wine and when available, organic fresh grapes, olives and nuts are also indicated. This custom helps with digestion, bio-availability and mineral balance.  Organic catechin-rich Green tea can also help to burn cheese’s rich saturated and unsaturated fat content while flooding the bloodstream with complementary antioxidants, blood-thinning compounds and immuno-building molecules. A2 cheese is also rich in important fats, like DHA as well as its many fat-soluble vitamines, like Vitamin A, D and the prized K-2 and B-12 etc..

Holistic Solutions to Low Stomach Acid and Slow Bowel Movement

With improper eating and the passage of time (aging), gastric juice secretions malfunction.The Standard American Diet combined to American conventional medicine  (including proton pump inhibitor and anti-acid prescriptions) constitutes a “perfect storm” combo for gastro-intestinal related and metabolic disorders. In this Presentation, we will learn about Self-help tests for both bowel movements and stomach acid and examine holistic solutions to better assimilate both nutrients and the “information” flow of food.

Session O: Dietary Supplementation & Optimal Longevity

Are non prescription pills, supplements and neutraceuticals useful or deleterious for durable health and optimal longevity ? Many conventional and integrative medicine, biogerontology and anti-aging specialists claim that  many dietary supplements like niagen (nicotinamide riboside), resveratrol, D-ribose, vitamin D3, antioxydants, Fish and MCT-Krill DHA-rich Oils, Algae, Vitamin B-12, metformin, ketones, Co-Q-10, PQQ, berberine, L-Carnitine, NAC, BDNF boosters, vitamins D & K-2 and many other supplements are safe and efficient insofar as risk prevention and longevity activators are concerned. This talk will show the data that either substantiates some of these claims or debunks them.

For example, on one of dozens of supplements we may review, fish oils, the viewer can confirm via mouse click  below the data that confirms that fish oils are less and less reliable as healthy sources of long chain Omega 3s, worse, not only the evidence debunked the claim that fish oils are cardio-protective, even if they may reduce tryglicerides, but they were shown via multiple published peer-reviewed meta-analyses to significantly increase cancer risks, including, but not limited to aggressive prostate cancer (ie with a 71 percent risk).

Thus, for fish oil supplements and other pills and extracts (what is called neutraceuticals), we will weigh or evaluate the credibility and strength of the evidence and pinpoint where the preponderance of the evidence for a given product’s safety and efficiency may lie. In addition, we will teach workshopees how to employ a few of the forensic detective’s truth-digging tools, thanks to which the workshopee will be better able to distinguish flawed and biased publications from truthful ones supported by strong science and intuitive knowledge.

Case Study A: Safe and Efficient Supplementation for Healthy & Optimal  Lifespans (Link)

Case Study B: Unsafe and-or inefficient Supplementation (Link)

Case study C: Examples of Dietary Supplements ending up as expensive urine

Case study D: A Published Study Claims a 20 percent increase of Liver Damage coming from Dietary Supplements

Case Study E: Resveratrol in a  capsule, food or bottle ? Depends if one is a mouse, a patient, holistically inclined or a marketing agent

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Session O: Chronic Stress & The Inner Saboteur

 Consciousness Disorders

“I regard consciousness as fundamental. I regard matter as derivative from consciousness”  Max Planck (leading expert in quantic physics, Nobel laureate)

For reasons that are still mysterious, within human brains, the combined activity of billions of neurons generates a conscious experience as well as the awareness of conscious reality. In this perspective, the founder of quantic physics, Planck, summed up his Life’s work by stating that consciousness is so fundamental to the human experience, matter and the universe that nothing would exist without it. A paper published by Dean Radin, PhD, in the peer-reviewed journal Physics Essays, explains how the double slit experiment has been used multiple times to explore the role of consciousness in shaping the nature of physical reality. (source)

Thus, it follows that the psychology of aging and the “science” of Consciousness activation are important pieces of the holistic optimal longevity code. In these realms, most centenarians and supercentenarians who make it to over 100 years appear to have mastered the art of chronic stress and drama control. Chronic Stress seriously impacts the mind-body, as a consequence, it tends to alienate an equanimity-based Consciousness as well as the Gut microbiota’s “mood” and the brain’s lobe that is the most evolved, the prefrontal cortex.

The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental effects of stress exposure. Even quite mild acute uncontrollable stress can cause a rapid and dramatic loss of prefrontal cognitive abilities, and more prolonged stress exposure causes architectural changes in prefrontal dendrites.Recent research has begun to reveal the intracellular signalling pathways that mediate the effects of stress on the PFC. This research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness”. (Nat Rev Neurosci. 2009 Jun; 10(6): 410–422. (Source)

Furthermore, the scientific litterature confirms  that most of these super-longevity achievers have avoided all of the major chronic diseases of their peers. The HM Institute’s longevity hero, Jeanne Calment for example was the epitome of an unflappable archetype who avoided chronic degenerative diseases until she quite smoking cigarettes and eating sweets at 119 years old. Multiple studies also positively correlate optimism with longevity. On the other hand, chronic stress, emotional scars, what is called ACES (advanced childhood emotional stressors) or childhood traumas, durable maternal deprivation, as well as Professeur Laborit’s “inhibition of action” process can all negatively impact the epigenetic expression of human genomes and the development of degenerative diseases.

In this Presentation, we will explore different causes to the self-sabotage behavior and offer holistic solutions thereto.

Case Study: Successfully resolving the Self-Sabotage Disorder (Link)

Session P: Hands-on Techniques to enhance Longevity and de-activate the Inner Saboteur

“It’s not because we are old that we don’t play, it’s because we don’t play that we get old” (George Bernard Shaw)

In this Presentation, we will teach hands-on exercises to optimally breath, move, meditate, see and activate key energy fields, including via acu-pressure, EFT, reflexology, aromatherapy, sophrology and more. If time allows, we will also delve into evaluation techniques like muscle testing (kinesiology), Chinese nail and tongue testing, stool & urine analysis, psycho-morphology and facial diagnosis, metabolic body types assessment, ear lobe examination (that can help to predict coronary crises), alternate nostril breathing, HRV support and other holistic tools like organoleptic testing that can assist us in pinpointing warning signs, some of which can be as useful as genetic and biochemical tests given their relevance, simplicity and immediacy.

Session Q: Advanced Cancer Protocols

 Optimizing the Cancer Control, Repair & Reversal Code: a precondition to Optimal Longevity

« …si j’avais un cancer, je n’irai jamais dans un centre anticancéreux classique. Seules les victimes du cancer qui vivent loin de ces centres ont une chance. » “If i had a cancer, i would never to to a conventional anti cancer center. Only cancer victims who live far from these centers have a chance”. (Source) Pr Georges Mathé (famous contemporary French oncologist

For H.M. Institute, there is no question that integrative oncology’s modalities and clinics are much better than conventional oncology clinics. The well known Professor Georges Mathé (oncologist) used to say: “Si j’avais une tumeur, je n’irais pas dans un centre anticancéreux » (Le Monde, 4 mai 1998) (“If i had a tumor, i would not go to an anticancer center”) (Source). Among a few other French oncologists who have questioned the very legitimacy of conventional oncology’s thinking and modalities, I’m invoking Georges Mathé because he was recognized in the US as a cancer, stem cell and bone transplant pioneer in that he proved as early as 1963 that cancer was curable via the immune system. He also demonstrated that stem cells could both heal radiation damage and fight cancer. Dr. Joseph H. Antin, chief of stem cell transplantation at the famous Dana-Farber Cancer Institute in Boston, summed up Mathé’s work: “It was quite a leap of scientific genius. He’s one of the original innovators. Much of what we have accomplished can be linked back in a fairly direct way to the work that he did in the 1950s and ’60s.” (“Dr. Georges Mathé, Transplant Pioneer, Dies at 88”New York Times, Source).

Notwithstanding their nuisance, cancer cells have mastered the art of longevity since their “innate evolutionarily-based intelligence” has tweaked its genome to produce a continuous fresh supply of telomerase enzymes thanks to which they can divide endlessly and remain forever “strong” and “young”. In this Presentation, we will unmask cancer’s intrinsic weaknesses and explain a few of its underlying mechanisms. But between cancer as a biological reality and conventional oncology as a system of deleterious dogmas, the central problem lies with Conventional Oncology.We will thus discuss the limits of conventional oncology in relation to the strengths of holistic cancer  protocols.

From 1991 to the 2018, published studies, including in the Lancet Journal, have proven beyond any reasonable doubt that systemic cytotoxic chemo-blasting more often than not doesn’t durably save lives of those who have “solid” cancers. The five year survival rates for liquid canccers (e.g. lymphomas and, inter alia, leukemias) are much better, but these malignancies often come back with a vengeance after the five-year period and-or have toxic effects that seriously affect the patient’s ability to reach a healthy 120 years of lifespan. Worse, the evidence shows that with conventional chemotherapy, cancer patients’ demise tends to be accelerated. While radiation and cytotoxic chemo do shrink tumors, there are no published studies the H.M. Institute is aware of that show a positive correlation between tumor shrinkage and significant long-term survivability. Thus, the emerging reality (for the last 40 to 50 years) is that most of these conventional medical interventions will weaken what can restore the patient’s “élan vital” (i.e., a notion from Prof. Henri Bergson which include the immune, digestive, microbiota, endocannabinoid and neurological systems) while fueling what metastasizes cancer, in particular, the microscopic circulating tumor and stem cells that most conventional oncologists still refuse to inform the patient about, in violation of medmal law and ethics. Even most of conventional oncology’s more recent targeted monoclonal antibodies, signaling inhibitors, genetic interventions and immunotherapeutics have toxic side effects that can be avoided with alternative and holistic oncology. Many of these targeted therapies including immunotherapeutics have been hyped misleadingly as new cancer “cure-alls”. While it is true that a small percentage of cancers go away with immunotherapeutics, these effects are usually not long lasting, the modalities are very expensive and the outcome of holistic oncology’s cases tend to be much better, provided the patient is compliant with a holistic lifestyle and restorative protocols.

Case Study: Integrative Versus Conventional Oncology Clinics: Strengths and Limitations (Link)

Case Study: Cancer Reversal with Holistic Oncology (Link)

In this Presentation, we will  give a few tips on how to holistically restore the body’s hijacked immune-surveillance mechanisms and revitalize the entire metabolism (the body’s “soil” or “bioterrain”) with holistic savoir-faire so that cancer can’t grow and in many cases, starts to shrink within 2 to 5 weeks

Session R: Thermal Medicine: A French Speciality that would be of Benefit for the US Health-Care system

“Primum non nocere” (First do no Harm) Hippocrates, the Father of medicine

Hippocrates’ based Thermal Medicine or Thermalism includes, but is not limited to Spa, massage, traditional hydrotherapy, peat baths, balneotherapy treatments,  sulphur-based spa drinking water, pleasures of water games, relaxation, saunas, fitness programs, beauty treatments (in particular with clays), detox, wine therapy and, inter alia, hyperthermia therapies, in particular hot baths and showers that come from the sulphur-rich volcanic waters in France’s southern Spa resorts (called “Thermes”, “station thermale” or “Cure thermale”).

This type of preventive and curative medicine is so safe, efficient and cost-friendly that the French National Heath-care system has offered this therapy free of charge since 1944 for all who reside in France (including American residents) and benefit from a doctor’s “thermes” prescription. It is one of the most popular healing systems in France. Many French People will take a three weeks health-vacation per year in one of France’s thermal centers  where they can  soak up hot sulphur-based thermal spring water, among other detox and rejuvenation holistic techniques. In this Presentation, we will examine the health and longevity benefits of this type of Medicine and wrap up with a word on how it could be of great benefit to the US Health-care system.

Case Study: Heat Shock Proteins and  Hormesis Mechanism

Heat and cold hydrotherapy and other holistic techniques will spur the cell’s production of heat shock proteins, whose effects can be both protective and beneficial to health. In this Presentation, we will explore this mechanism in light of healthy lifespans. (Link)

Session S:  Optimizing balanced  Hormones & Neuro-transmitters & Regulating Cytokines,

There are over fifty known hormones. Almost all affect personality and physiology. At least seven vary greatly with gender. With the gift of Life, we have been equipped with key messaging molecules, three are central: neurotransmitters, cytokines and hormones. With the passage of time, many of these molecules get roughed up and imbalanced. This is why these messaging molecules need regular holistic “tune-ups”, especially then someone is trapped in the vicious cycle of accelerated aging. By holistic tune-ups, we don’t necessarily mean hormone or even bio-identical hormone replacement therapies. We are first and foremost talking about epigenetical fine-tuning of molecules that help us to be in coherence with our purpose, thereby optimizing healthy longevity and JDV.

The Bliss & longevity Hormone Chemistry Network

“There is no fear in love: but perfect love casteth out fear”. (1 John 4: 18)

The human body is equipped with dozens and dozens of key hormones and neuropeptides that need to be holistically tweaked, activated and balanced if humans are to live healthy lifespans with JDV to 120 and beyond in accordance to Genesis and human potential. The bonding and “love” chemical called oxytocin is key. This “double casquette” molecule is both a peptide hormone and a neuropeptide, as a result, its tasks are widespread and key, especially if humans are to shift from a morbid fear-based society to a more spiritual trust-based civilization. Not enough of it leads to distrust,  fear and defeat, while just enough, the right balance will be conducive to bonding, trust and biological Life’s mission, self-replication.

Then we have the “mother” hormone, pregnenolone as well as the more common “trio soldiers”, estrogen, progesterone and testosterone, all of which are key for happy and healthy lifespans and offspring reproduction. Cortisol and thyroid hormones are also necessary as well as many other endogenous compounds that make up the human neuropeptide-hormonal communicatory network. When thyroid gland dysfunctions, the body’s entire metabolism is off. So this endocrine organ should be promptly fined-tuned. The adrenal glands often get exhausted and can’t produce enough of its stress-related hormones, as a result, energy exhaustion and mitochondrial dysfunction tend to follow. So it’s important to maintain healthy the thyroid and adrenal glands with the H.M Institute’s holistic restorative program. In this Presentation, we will explore some of the more important hormones that modulate longevity pathways.

 Case Study A on DHEA, Pregenolone, Testosterone, Progesterone and Estrogen (Link)

Case Study B on Human Growth Hormone (HGH), IGF-1  Melatonin, Cortisol & Thyroxine (Link)

Case Study C on The Vasopressin & Oxytocin (Link)

The Oxytocin-Vasopressin Pathway in the Context of Love and Fear

Oxytocin (OT) and vasopressin (VP) are ancient peptide molecules with many behavioral and physiological functions. These pleotropic peptides evolved from a single genetic source  OT and VP, with their receptors, function as an integrated, adaptive system, allowing the mammalian body to survive, maintain homeostasis, and reproduce. For optimized results, need to be tweaked synergistically.

“..complex behavioral functions, including selective sexual behaviors, social bonds, and parenting require combined activities of OT and VP. The behavioral effects of OT and VP vary depending on perceived emotional context and the history of the individual.” Front Endocrinol (Lausanne). 2017; 8: 356. (Source)

Adding to the complexity of this pathway, the OT and VP receptors are quite variable and need to be epigenetically tuned. In this Presentation, we will look at a few techniques that optimizes this combo.

Case Study: The Klotho Hormone as well as a few others

Klotho is a pleiotropic protein that circulates as a hormone following cleavage from its transmembrane form. It regulates insulin (Kurosu et al., 2005), Wnt (Liu et al., 2007), and fibroblast growth factor (FGF) (Urakawa et al., 2006) signaling. Overexpression of klotho extends life in organisms (Château et al., 2010, Kurosu et al., 2005), up to 31% in one study (Source), whereas lowering klotho shortens it (Kuro-o et al., 1997). Elevated klotho levels in humans, resulting from genetic variation (Arking et al., 2002, Dubal et al., 2014, Yokoyama et al., 2017), is also associated with longer lifespan (Arking et al., 2002, Invidia et al., 2010) In this Presentation, we will show via power point different holistic techniques, nutrients and,  among other elements  supplements and  that can significantly help to activate this protein-hormone. We will also learn what undermines this protein-hormone.

Neuropeptides, Neuro-transmitters & Healthy Longevity

Neuropeptides are small protein-like molecules (peptides) used by neurons to communicate with each other. They are neuronal signalling molecules that influence the activity of the brain and the body in specific ways. Different neuropeptides are involved in a wide range of brain functions, including analgesia, reward, food intake, metabolism, reproduction, social behaviors, learning and memory. Neuropeptides are related to peptide hormones, and in some cases peptides that function in the periphery as hormones also have neuronal functions as neuropeptides In this perspective, the human genome contains more than 70 genes that encode precursors of neuropeptides. At present about 100 different peptides are known to be released by different populations of neurons in the mammalian brain.

“…neuropeptides are the most diverse class of signaling molecules in the brain engaged in many physiological functions. According to this definition almost 70 genes can be distinguished in the mammalian genome, encoding neuropeptide precursors and a multitude of bioactive neuropeptides” (Methods Mol Biol. 2011;789:1-36)

Neurotransmitters are endogenous chemicals that enable neurotransmission. It is a type of chemical messenger which transmits signals across chemical synapses which are associated to neurons. Neurons form elaborate networks through which nerve impulses (action potentials) travel. Each neuron has as many as 15,000 connections with neighboring neurons. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available from the diet and only require a small number of biosynthetic steps for conversion. Neurotransmitters play a major role in shaping everyday life and functions. Their exact numbers are unknown, but more than 100 chemical messengers have been uniquely identified. (Source)

GifBrainChemicalsReuptake

Defining Excitatory and inhibitory processes in Neuro-transmitters (Link)

Case Study on Serotoin, Dopamine, Acetylcholine, Norepinpehrine and GABA (Link)

Neurotransmitters’ Imbalance

Because neurotransmitters are functionally integrated with the immune system and the endocrine system (including the adrenal glands), neurotransmitter imbalances can cause widespread health problems such as Brain fog: loss of mental focus, ADD, ADHD, impaired memory, poor decision making.  Insomnia: difficulty falling asleep, staying asleep, or both;  Pain: migraines, fibromyalgia, fatigue. Obesity: metabolic syndrome, insulin resistance, and diabetes; Mood disorders: depression, mood swings, irritabilit  Anxiety: panic, obsessions, PTSD Behavioral disturbances  addictions, binge eating, compulsions impulsivity, gambling, autism and more.

Cytokines Signaling Molecules, Cytokines-Storms, Inflammaging & the Body’s integrity

Cytokines are a broad group of signaling proteins that are produced transiently, after cellular activation, and act as humoral regulators which modulate the functions of individual cells, and regulate processes taking place under normal, developmental and pathological conditions (Dinarello et al. 1990; Meager 1998).  Unlike hormones, cytokines are produced by cells which are not organized in special glands and which act systemically to affect biological phenomena such as inflammation, wound healing, organogenesis and oncogenesis. Cytokines include, but are not limited to chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors.

The Role of endogenous cytokines in premature death, disease, health and longevity

While cytokines are important for embryogenesis and fighting off infections and in other immune responses, they can get dysregulated, lose their balance, at which point conditions like inflammation, trauma, sepsis,  schizophrenia, major depression, Alzheimer’s disease and, inter alia,  cancer can ensue.

Case Study A: Homeostatic Imbalance  and Cytokine-storms (Link)

“Scientists said they were struck by how suddenly and overwhelmingly the 1918 flu struck seven macaques that were tested (…) The virus spread faster than a normal flu bug and triggered a “storm” response in the animal’s immune systems. Their bodies’ defenses went haywire, not knowing when to stop, researchers said. The lungs became inflamed and filled with blood and other fluids.  (…) “There was some surprise that it was that nasty,” University of Washington virologist and study co-author Michael Katze said. “It was the robustness of the immune system that helped victimize them.” (Source)

Case Study B: Holistic Interventions (Link)

With so many unhealthy conditions that pervade the American Nation, from over 80,000 unregulated toxic chemicals (toxicants), electrical pollution, chronic stress, massive autoimmunity,  desertification, drought and bacterial resistance, it is likely that there will be in the not too distant future pubic health crises and cyto-storms that will lead hundreds of thousands if not millions of tax-paying Americans into the death throes of cyto-storms and other biological and chemical onslaughts. It will therefore be useful to teach a few holistic techniques which can turn off cytokines switches. Furthermore, as inflammation accumulates, even and especially slow-growing inflammation, aging accelerates. Biogerontologists call this condition “inflammaging”. In this Presentation, we will look at different holistic ways to turn “off”  inflammatory  switchs, thanks to which we can reduce premature senescence.

Case Study C: Sepsis

In order for the elderly and less elderly to achieve 120 years, they must be knowledgeable about what can quickly kill them. One of these quick-kill modalities is a trip to a conventional hospital where a patient can acquire some form of infection, and acquire sepsis. Sepsis is a common American cause of death in conventional hospitals. Each year, an estimated 1 million Americans get sepsis (Source) and up to half of them die from this condition and-or the conventional treatment. (Source)  From a serious examination of the facts, it appears that Conventional hospital treatments for most chronic diseases, including sepsis are crafted more to maximize cash-flow than to optimize the People’s “blood-flow”, the public good, public health, good medicine, healthy longevity. According to the Agency for Healthcare Research and Quality, sepsis is the most expensive (i.e. lucrative) condition being treated in U.S. hospitals, costing more than $24 billion in 2014. (Source). A big proportion of the hospitalized elderly will die from this nosocomial disease. The condition becomes particularly deadly if the infection involves methicillin-resistant or vancomycin-resistant Staphylococcus aureus (MRSA or VRSA) bacteria, both of which, like cancer cells, have become resistant (stronger) to conventional medicine’s weapons of massive cellular destruction. These and other common hospital-acquired infections starts with symptoms of infection and can too often progress to septic shock, (Source) at which point the throes of death become a both a credible and creeping reality.

In this Presentation, we will review what to do (and take) and not do (and not take) when one needs to be present in infected areas. As we saw in the case above on the Spanish Flu, “cytokine storms” usually hit the worse those who have a healthy immune system, so the holistic preventive and curative solutions are not always to have the strongest immune system, albeit robust immunity is needed for most conditions. Thereafter, we will hone in on different holistic treatments that can resolve infections in generals and sepsis in particular. While antiobiotics are not always counter-indicated, they should only be used at the last resort since holistic medicine can be much safer, cost-friendly and effective in resolving infections and septic shocks without damaging the human organism. Consultation with one’s competent holisticlly trained doctor is encouraged.

Case Study D: Influenza Pandemics (Link)

Session S (bis):  Activating & Tweaking Key Longevity Genes

“Therefore I should infer from analogy that probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed.” (Darwin, Charles. On the Origin of Species. London: John Murray, Albermarle Street. 1859. pp. 484, 490)

In this Presentation, we will focus on activating three families of Longevity genes: the 7 members Sirtuin family, the APOE tribe and the wild FOXOs, a few members of whom can be helpful insofar as keeping human cellular repair and other longevity systems in decent shape. FOXO4 for example is elevated in senescent cells. (Source). Thus, to efficiently address senescent cells, we must also modulate this SNP (gene variation). Among other examples, let us consider one FOXO activator that is presently in the public debate.

Case Study A: SNPs, Methylation & other Pathways (Link)

Case Study B: FOXO3 Activators and Rejuvenation (Link)

Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity. FOXO proteins represent a subfamily of transcription factors conserved from Caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin and insulin-like growth factor signaling. In particuar FOXO3 appears to be especially interesting for optimal longevity.

“…. Several of these aging phenotypes were associated with FOXO3A genotype. Long-lived men also exhibited several biological markers indicative of greater insulin sensitivity and this was associated with homozygosity for the FOXO3A GG genotype. Further exploration of the FOXO3A gene, human longevity and other aging phenotypes is warranted in other populations. (Source)

In this Discussion, we will discuss what the ongoing research is with FOXO genes as well as holistic and nutritional approaches to activate and optimize the best of this Gene group.

Case Study C: Other Longevity Genes, the Continuum of Ancestral Genes & the universal nature of biochemistry (Link)

Session T: Mitochondrial Bio-Genesis’ Restoration

The capacity for mitochondrial biogenesis has been shown to decrease with age, and such decreased mitochondrial function has been associated with diabetes and cardiovascular disease. (Source)  Aging and disease can induce changes in the expression levels of proteins involved in the fission and fusion mechanisms of mitochondria, thus creating dysfunctional mitochondria. (Source). One hypothesis for the detrimental results of aging is associated with the loss of telomeres, the end segments of chromosomes that protect genetic information from degradation (Source). Telomere loss has also been associated with decreased mitochondrial function. Deficiency of telomerase reverse transcriptase (TERT), an enzyme that plays a role in preserving telomeres, has been correlated with activated p53, a protein that suppresses PGC-1α (Source).Therefore, the loss of telomeres and TERT that comes with aging has been associated with impaired mitochondrial biogenesis. AMPK expression has also been shown to diminish with age, which may also contribute to suppressing mitochondrial biogenesis. (Source)

Because the mitochondria is responsible for many important cellular functions, from apoptosis, to the production of ATP, ROS and much more, an optimal longevity program needs to figure out the best holistic strategies to strengthen this primitive bacteria. While Mitochondria dysfunction is only one of twenty aging hallmarks, it is one that has gotten a lot of attention in longevity circles. In this presentation, we will show how we can enhance healthy lifespans by holitically tweaking  mitochondria production and regulation, from BDNF promoting exercises, to holistic nutrition, biophotomodulation, meditation,  nutraceuticals, hormesis and more.

Case Study A: Pyrroloquinoline quinone (PQQ) and Mitochondrial Biogenesis (Link)

Case Study B: Other Mitochondrial enhancers (Link)

Session U: Stem Cells: Repair, Replacement & Regeneration

As humans age and oxidize (lose electrons), inter alia,  stem cells eventually lose their ability to divide and thus go into decline, at which point human bodies are unable to replace the stem cells that have migrated, differentiated, or died. Hence, the increase of age-related disorders, if only because the main function of stem cells is to repair and replace damaged tissues.

In adults, stem cells are responsible for the repair of damaged tissues, and the replacement and regeneration of tissues that turn over rapidly, such as the skin, blood or the lining of the intestine. Recent evidence suggests that most, if not all tissues may contain stem cells with the potential to repair damaged tissue”. (Source)

Because stem cell exhaustion is an important hallmark of aging, geroscientists and biogerontologists are working on attempts to rejuvenate stem cells with synthetic chemicals and high tech technology. However, most times, this leads to both drug resistance and significant complications and toxic effects. On the other hand, integrative and regenerative medicine focuses on the  early “banking” (storage) of stem cells that can be inoculated to worn out tissues when needed. These integrative clinics are also starting to use autologous stem-cells via injections on the same visit day. Holistic medicine’s focus is on preserving and holistically replenishing stem cells for quality living over 100 years. (Source) Before dieing,  supercentenarians tend to have fewer and fewer stem cells, less than a handful, it’s been recorded that one supercentenarian lady was living just on two stem cells. In this Presentation, we will therefore examine holistic techniques to both preserve and produce quality stem cells that can repair and replace tissues until 120 years or so.

Case Study A: General Stem Cell Longevity boosters (Link)

Case Study B:  Stem Cells, Natural Beauty and Longevity (Link)

Session V: Telomerase Therapy

Telomere Shortening tends to accelerate Aging

Located at the end of our chromosomes, these DNA repeats modulate the number of times cells divide. The longer the telomeres, the more cells divide, from 50 divisions or doublings to 70 for example, which corresponds to about 120 years, which has been called the Hayflick limit. The shorter telomeres get, the less they divide. When they can no longer divide, they then go into the senescence mode, and that not only clogs up the system, but accelerates aging.

Case Study: Telomerase Activators (Link)

Session W: Cellular Senescence, Autophagy Regulation & Amyloidosis

When telomeres shorten, cells can’t divide anymore, at which point they become senescent. When we are vibrant, senescent cells are thought to be cleared by the immune and the autophagy systems, as a result, healthy lifespans tend to be much longer. On the other hand, when senescent cells stick around secreting harmful inflammation molecules and sticking to healthy cells, aging is accelerated. Canakinumab was manufactured to dampen this senescence inflammation called infammaging. But this drug has its limits. (Source).

Unresolved DNA damage can impair cellular function, promote disease development, and accelerate aging (López-Otín et al., 2013). To prevent such undesired consequences, cells are equipped with a range of DNA repair mechanisms (Hoeijmakers, 2009). However, these mechanisms are not flawless. When repair falls short, tissue integrity is still at least initially maintained by independent stress-response mechanisms as apoptosis and cellular senescence (de Keizer, 2017). Senescent cells are permanently withdrawn from the cell cycle and generally develop a persistent pro-inflammatory phenotype, called the senescence-associated secretory phenotype (SASP) (Coppé et al., 2008). The SASP influences the cellular microenvironment, which can be beneficial early in life or in an acute setting of wound healing (Demaria et al., 2014, Muñoz-Espín et al., 2013). Unlike apoptotic cells, which are permanently eliminated, senescent cells can prevail for prolonged periods of time and accumulate with age (Krishnamurthy et al., 2004). Because of their low but chronic SASP, persistent senescent cells are thought to accelerate aging and the onset of age-related diseases (de Keizer, 2017). Indeed, senescence has been associated with a plethora of (age-related) pathologies, and, conversely, genetic clearance of senescent cells can delay features of aging (Baker et al., 2016).

In this Presentation, we will examine a few holsitic techniques that can help to clear cellular senescent cells as well as activate autophagy and deactivate Amyloidosis.

Case Study A:  A Review of different synolitics (senescent cell removers) (Link)

Case Study B: A review of different autophagy inducers and the link to longevity activation (Link)

When things are running smoothly in a cell, autophagy occurs at a low level, helping to recycle worn-out cellular components. It’s a type of ‘maintenance’ mode. But when things become stressed in a cell (not enough nutrients or energy, dysfunctional components, or invasion by microbes), autophagy kicks in its stress response mode. Activation of autophagy counteracts the age-associated accumulation of damaged cellular components and enhances the metabolic efficiency of cells. (Source) In particular, autophagy can be activated to remove dysfunctional mitochondria (mitophagy) which produce a lot of harmful reactive oxygen species (ROS) that degrade the cell (Source) These processes are reported to extend the lifespan of several species. (Source)

In this Presentation, we will show different ways to promote autophagy within different tissues. Exercises Dietary Restriction and fasting are all autophagic. Taken certain supplements also, in particular nicotinamide Nicotinamide is a member of the vitamin B family and an ingredient for making the essential energy molecule nicotinamide adenine dinucleotide (NAD). It has been reported to forestall Alzheimer’s through increasing autophagy in neurons. (Source) It can also induce autophagic recycling of mitochondria, which  is beneficial to cellular health and longevity. (Source)

Case Study C: Spermidine and Autophagy

Spermidine has been linked to hair growtharterial health, longevity, epithelial stem cell modulation, and autophagy activation. In effect, spermidine is another one of those molecules that erodes with non holistic aging and thus, needs to be seriously boosted.

“… Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells. In addition, spermidine administration potently inhibited oxidative stress in ageing mice. In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis. Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan. The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells.Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity. (Source)

In this Presentation, we will review different techniques and foods to increase spermidine (Source), some of which are soybean, wheat germ and certain ripe cheese.  (Source)

  Case Study D: Amyloidosis and the Art of Removing extracellular Deposition of Misfolding Proteins (Link)

Many centenarians and superccentenarians avoid chronic diseases and surf on a smooth plateau until the stem cells, inter alia, can’t keep up with the repair and-or replacement of tissues. Thereafter, cellular impairment can be massive, thanks to which the supercentenarian doesn’t have to wait too long before passing to the next round of spiritual adventures. And the most decisive element that accounts for the “extreme” elderly’s demise is less cancer, diabetes, lupus or heart attacks than the misfoldment of their own proteins, the TTR of which is a big one. ANd this misfoldment can clog up mutliple organs (the heart, kidneys and brain being three major ones) and be systemic.

“The systemic amyloidoses are a family of diseases induced by misfolded and/or misassembled proteins. Extracellular deposition of these proteins as soluble or insoluble cross β-sheets disrupts vital organ function.1 More than 27 different precursor proteins have the propensity to form amyloid fibrils.2 The particular precursor protein that misfolds to form amyloid fibrils defines the amyloid type and predicts the patient’s clinical course. Several types of amyloid can infiltrate the heart resulting in progressive diastolic and systolic dysfunction, congestive heart failure, and death. Treatment of cardiac amyloidosis is dictated by the amyloid type and degree of involvement. Consequently, early recognition and accurate classification are essential.3 (Source)

Case Study E: The Transthyretin transport protein (TTR)

Transthyretin (TTR) is a transport protein in the serum and cerebrospinal fluid that carries the thyroid hormone thyroxine T4 as well as the retinol-binding protein. This is how transthyretin got  its name: transports thyroxine and retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid. With time and unholistic living, this protein readily misfolds. In this Presentation, we will examine what the bio-tech Industry is working on to address this misfoldment challenge, and thereafter, we will look at Holistic medicine and its ability to both prevent and signficantly delay the onset of amydoilosis via this TTR and to mitigate it’s cellular havoc when it’s already there.

Session X: Circadian Rythms Activation & DNA Repair

The aging hallmark relative to the circadian pathway is relatively new. The 2017 Nobel Prize in Physiology (Medicine) went to scientists who dug deep to unravel some of the mysteries of circadian biology. When humans don’t respect Nature’s rhythms like the sleep-wake (melatonin-cortisol) cycle, aging is accelerated.

Deep restorative Sleep is one of Happiness Medicine’s twelve most important wellbeing tools, more powerful than pills, surgery and any high-tech procedure combined, because none of  conventional medicine’s weapons and procedures can repair damaged DNA, spur rejuvenation hormones, charge up neurotransmitters, calm inflammation, calm the mind  and detox beat-up tissues like deep  restorative sleep.

In this Presentation, we  will examine the best deep sleep protocols, including, but not limited to different ways to holistically resolve Apnea, snoring, frequent urination and other sleeping problems. As for holistic ways to promote DNA repair, this topic is so important that we will only briefly talk about it in this Seminar. Seminar B will focus more on this longevity mechanism.

 Case Study A: Nicotinamide Adenine Dinucleotide, NMN & DNA Repair

NAD+ is a key co-enzyme and metabolite called Nicotinamide Adenine Dinucleotide (NAD+) that the mitochondria in every cell of our bodies depend on to fuel all basic functions. (Source)  Over time, decreasing NAD+ promotes chronic diseases and aging. (Source). Different scientists claim that is one of the key factors that explains why we age (Source). In this NAD+ plays a key role in communicating between the nucleus of cells and the Mitochondria that power cell activity (Source). One of its key role is to ensure DNA repair, a longevity function which is essential.

“DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD+ (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD+ to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate–ribose) polymerase], a critical DNA repair protein. As mice age and NAD+ concentrations decline, DBC1 is increasingly bound to PARP1, causing DNA damage to accumulate, a process rapidly reversed by restoring the abundance of NAD+. Thus, NAD+ directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging.” Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A. Sinclair. A conserved NAD binding pocket that regulates protein-protein interactions during aging. Science, 24 Mar 2017: Vol. 355, Issue 6331, pp. 1312-1317  (Source) (Full article)

In this perspective, it would appear that the  supplement called with Nicotinamide Mononucleotide (NMN), the immediate precursor used by the body to create NAD+, can replenish stores of NAD+ and  help to reverse the aging process.

Case Study B: The metabolite NAD+ and DNA Repair (Link) 

Case Study C: Nicotinamide Riboside  (Link)

Case Study D:  Pterostilbene and Resveratrol Combo (Link)

Session Y: Monitoring Tests: From Self-testing to Genetic, Gut, Telomere & Methylation Evaluation

In this Presentation, we will thus delved into some of the most important holistic, functional, integrative and allopathic tests that can be done to determine health and disease status, (diagnosis) to monitor disease progression (prognosis) and to evaluate the safety and efficiency of treatment plans and longevity protocols. We will also quickly look at dozens of biomarker lab tests that can detect underlying chronic conditions that are not yet symptomatic. Like with gut and genetic tests.  We will also look at biological age testing, in particular telomere and epigenetic (methylation) tests.

Although proactive prevention is key in health, most people don’t get motivated to have a proactive & preventive holistic lifestyle until the “proof of the pudding” via lab tests and-or organ failure corroborate threatening signs. Integrative medicine experts  have dozens and dozens of lab tests to sell to their clients. But these can be quite expensive and many are not reimbursed by insurance companies. This section will thus focus on the most important ones. We will also go over a few self-care tests that can be done by the patient (i.e., via en educated examination of the ears, the eyes, tongue, poop, urine, smell, pelvic gait, temperature and more).

Session Z: Update on Today’s Bio-Engineering of anti-aging pharmaceuticals & Hi-Tech procedures

In this last Section, we will look at some of the most interesting innovative technologies that are either freshly on the market or still being worked on, from biogerontology institutes in France,  China, Japan, Germany, Israel to those in the US, including the Silicon Valley bio-tech giants and their prestigious scientists and billionaires. Some of these medical innovations target many of the aging mechanisms we have seen, from. telomerase insufficient, to senescent cell removal, (senolytics), caloric restriction mimickers, blood donor plasma transfer, nano-robots, gene editing, stem cell cyro-preservation, Sirtuin-activating molecules and the like). Pharmacological treatments have also been shown to extend lifespan through activation of autophagy, indicating autophagy could be equally a potential target to modulate animal and human lifespan. (Source)

Case Study A: Targeting Senescent Cells with  Conventional Pharmaceuticals

Not too long ago, scientists have genetically modified mice to remove their senescent cells, allowing the rodents to live longer and reducing plaque buildup in their arteries. (Source). Such genetic alterations aren’t practical for people, but researchers have reported at least seven compounds, known as senolytics, tha can terminate senescent cells’s lifespan. A clinical trial is testing two of the drugs in patients with kidney disease, and other trials are in the works..

Case Study B: What are Senolytics ? (Link).

Case Study C: Longevity Peptides (Link)

Brief Analysis on a few of the pending Longevity Human Clinical Trials

As we tried to show, we can have great longevity results with worms,  mice or even the naked mole rat, but for the “rubber to meet to road”, we need convincing well-designed impartial human clinical trials to ascertain if a supplement, pharmaceutical or whatnot works and is safe. Because the key three issues for the common consumer are and have always been these: Does it work ? Is it Safe ? And cost-friendly ? Most clinical trials will cover the first two issues via rigorous experimenations. We will look at the types of trials that are the most compelling, including their built-in flaws. But the ultimate determination comes from the Court of public opinion, first from peer-reviewed journals, then from consumers and lastly via class action suits, or the like.

Session : Summary

 Honing in on Key Rejuvenation and Life Extension Techniques

This Talk will hone in on what appears to be the quintessence and most promising of the present Research on significant and healthy lifespan extensions, most of which can be subsumed within three general categories: Telomerase cellular delivery via gene-tweaking; DNA repair mechanisms via molecular signaling and Metabolic Fine-tuning via holistic savoir-faire.

First Category relative to telomerase activation: Even though an abundance of telomerase enzymes and long telomeres can accompany conditions like cancer and accelerated aging, contemporary Research (including today’s 51  clinical trial on telomerase) is investing hundreds of million of dollars on a relatively new gene-therapy what was invented in 1999. Today, after 18 years of experimentation, longevity scientists are honing in on the telomerase enzyme as one of the central rejuvenation engines that could significantly reset the aging clock of somatic cells.  (See Source)

The second category is focused on DNA repair mechanisms and sirtuin genes. Many Longevity experts and Biogerontologists claim that aging’s central  hallmark is  characterized by the failure of DNA repair mechanisms to correctly unfold and fix the cell’s accumulated damage.

As a consequence, genomic instability accumulates and with it, carcinogenesis, other degenerative diseases and accelearted aging,  which would be one of Nature’s ways to invite death to end a person’s healthy lifespan for having excessively deviated from evolutionary biology. Professor Sinclair from Harvard is one of the main scientists who has invested a lot of time and effort in this realm. His  Lab has been focused on this question for years, first on wine’s resveratrol molecule and more recently on NAD +, inter alia. (See Exhibit D for illustrations)

The Third Category is hinged more on metabolic and holistic medicine, in particular of how food, movement and fasting can turn on and off epigenetically switches that will activate survival, feel-good and longevity genes. While the proponents of this school are not as extravagant or ambitious as the first two other schools in terms of extreme longevity to over 150 years, it’s theoretical foundations are coherent while its evidentiary basis is supported by petri dish, animal, comparative studies, epidemiology and non-randomized human clinical trials. Professor Seigfried, Longo, Ornish and the Happiness Medicine Institute’s Team are a few of its proponents. (See Exhibit B for illustrations).

In addition to a scant review of the pending clinical trials on senolytics, C.R. mimetics, senescent cells, what the National Institute of Aging and other Longevity Research institutes are working on and a word on the inter-connectivity of all of aging’s hallmarks, this Section will therefore weigh the central arguments of each of these three schools and make a factual determination as to which avenue of Research may be the most promising in terms of the People (ie, and not just the wealthy one-percent who can afford a one million dollar longevity treatment “shot”) being able to benefit from an affordable and meaningful access to the best optimal longevity tools that will significantly extend healthy Lifespans for the majority in the here and the now while  contributing in resolving both the Nation’s social security and the national debt crises.

 The Optimal Longevity Tune-up Protocol in a Nutshell

To maximize a healthy lifespan, the first physiological tune-up procedure that is usually needed accross the board is to address the Brain-Gut Axis by optimizing the patient’s sleep patterns followed by stress management protocol, a plan to  clear and clean up the excretion and detox pathways (which includes the oral cavity) and by making sure water & food intakes are personally optimized as well as the microbiota’s diversity and balance and the workshopee’s entourage field.

When the body is freed from nutritional imbalances, toxins, parasites, infections, auto-immunity, inflammation, oxidation, emotional scars, energy blocages, toxic fields and other co-morbidities, the workshopee will feel, digest and poop better, at which point the patient can better activate his-her body’s main bio-chemical signaling systems (ie, hormones, cytokines and neurotransmitters), thanks to which all of the body’s major physiological systems can get fine-tuned for optimal performance, including, but not limited to the body’s stem-cell based repair mechanisms, rejuvenation hormones and longevity genes.

In this Presentation, we will outline part of the Optimal Longevity Protocol (Strategy) to significantly reduce all  risks of chronic diseases while meaningfully increasing one’s lifespan to over 100 years. For the compliant good candidates, over 120 years. Seminar 2 and 3 will complete this Protocol.

Case Study A: The Healing Milieu & the Entourage Effect (Link)

Case Study B: The Holistic Therapeutic Effect Principle (Link)

 Conclusion

“My people are destroyed from lack of knowledge” (Hosea 4:6).

Aging is defined as a progressive decline in intrinsic physiological function, leading to an increase in age-specific mortality rate and a decrease in age-specific reproductive rate. Some of the major theories of aging that we have examined include telomere shortening theory, epigenetic and genetic regulation theory, stem cell theory, mitochondrial dysfunction, metabolic and immune deregulation, proteostasis loss and, among others, the gut microbiota regulating theory. We saw that some of these aging hallmarks could be favorably fixed. We also saw that fixing the roots of aging also benefits the resolution of most chronic diseases.

However, not all scientists  agree on all of the causes that explain the hallmarks of aging we identified, and in particular, the hierarchy of causation (which causes are the most important). But for the Happiness Medicine Institute’s executive Committee, the central cause is this constant onslaught of low and not so low bombardment of chemicals, fake food and chronic stress the American government still refuses to properly regulate as well as the refusal of those who control the Government to promote a holistic culture based on sustainability, holistic medicine and, inter alia, an UBI policy. If these conditions were respected, then most people would avoid chronic diseases, at which point the red carpet of 120 healthy years would unfold.

Since life began on Earth roughly 3.5 billion years ago, five major mass extinctions and several minor ones as well, have led to large and sudden drops in biodiversity and genetic variation. (Source) The Phanerozoic eon (the last 540 million years) marked a rapid growth in biodiversity via the Cambrian explosion, a period during which the majority of multicellular phyla first appeared. The next 400 million years included repeated, massive biodiversity losses classified as mass extinction events. In the Carboniferous, rainforest collapse led to a great loss of plant and animal life. The Permian–Triassic extinction event, 251 million years ago, was the worst; vertebrate recovery took 30 million years. The most recent, the Cretaceous–Paleogene extinction event, (Named the Holocene or Anthropocene extinction) occurred 65 million years ago and has often attracted more attention than others because it resulted in the extinction of the dinosaurs, today’s birds of which are one of the few flying creatures we still can enjoy. And since the emergence of humans, an ongoing biodiversity reduction and an accompanying loss of genetic diversity had grown almost exponentially. In the last 40 years, over half of wild Life has gotten destroyed. (The number of wild animals on Earth has halved in the past 40 years, according to a new analysis. Creatures across land, rivers and the seas are being decimated as humans kill them for food in unsustainable numbers, while polluting or destroying their habitats, the research by scientists at WWF and the Zoological Society of London found”(Source)

Likewise with the destruction of our own bio-diverse microbiota, those little critters (archaea, fungi, viruses, bacteria etc) whose millions of prokaryotic genes continuously cross-talk with our own eukaryotic genes, who were on Earth before humans, who were instrumental for the key mechanisms of this thing called Life many billions of years ago and who continue to guide us to healthy longevity or an inflammatory death. Without holistic medicine and a robust gut, optimal longevity, like the Planet’s survival, will remain too difficult to achieve.

GIfLovePeaceMandala

The expected Benefits from attending these three one-day long Seminars

“Man surprised me most about humanity. Because he sacrifices his health in order to make money. Then he sacrifices money to recuperate his health. And then he is so anxious about the future that he does not enjoy the present; the result being that he does not live in the present or the future; he lives as if he is never going to die, and then dies having never really lived.” The Dalai Lama

With this above-mentioned holistic knowledge, everyone who is motivated and compliant with holistic lifestyle and most of these longevity techniques and who has not gotten into serious debilitating accidents, including surgical, radiological and drug major incidents, should be able to reach the supercentenarian birth-right status without major chronic diseases, whatever the workshopee’s family history may be in terms of weak genetic links and SNPs (pronounced “snips”).

In particular, the knowledge imparted, if applied, can favorably impact up to 18 biomarkers, this means to say that the workshopee’s blood pressure, sugar stability, oxygen intake, neurogenesis, immune-regulation, hormonal signaling, insulin sensitivity, neurotransmitter firing, cholesterol-lipid profile, oral health, heart rate variability, hypothalamus-pituitary-adrenal axis homeostasis, mitochondrial function, microbiota diversity, bowel movement, deep sleep patterns, inflammation control (measured by CRP, interleukin 6, TNF alpha, inter alia) and many other health and longevity biomarkers should significantly improve within one to three months if not earlier.

As a double bonus, the workshopee, if holistically compliant, will strengthen his-her bio-terrain to such an extent that she-he will be quasi-immune from contracting some of the more common chronic “civilization” diseases, in particular, the Big Five, considered to be today’s “Black Plagues”: diabetes, cardiovascular events, cancer, auto-immunity and mental disorders like Azheimers, Depression and Parkinson. And as a last double bonus, the workshopee should appear biologically younger with visible radiance and save money by getting rid of most or all of his-her “symptom” based prescription drugs, in conformity with Dr. William Osler’s recommendation (see quote above) and the exigencies of  Reason.

The supercentenarian birth-right status starts at 110 years, but our human biological potential, as of this writing, has been formally determined to be around 120 years (called the Hayflick limit), the epitome of which is represented by a French Mediterranean upbeat lady Jeanne Calment who died at 122 and a half after experiencing a Life of purpose, enjoyment and holistic savor-faire, including via 2.2 kilos of dark chocolate each week, lots of dancing, fencing, socializing, musicotherapy, red wine and relishing in the Mediterranean Lifestyle with her daily unflappability vibe.

However, more and more research indicates that some time in the not too distant future, we may be able to tweak our genetic material, longevity pathways and wellbeing genes to prolong a healthy lifespan to beyond 140 years.  But we are not there yet. We will therefore focus on what we know is achievable, a Lifespan of 120 years in relatively good shape, with all of one’s conscious awareness and major bodily functions working enough to experience Life to its fullest, with what we call in France, “La Joie de Vivre”.

Ch. Joubert (H.M. Institute Director)

Workshop on psycho-neuro-endocrinology and hormonal balancing Workshop

Workshop Presenter

Pr. Joubert: Biogerontologist  and holistic oncology expert from France. Former Professor of Law and Holistic Medicine.  (Bio)  (22)

Director of the Happiness Medicine Institute, the Optimal Longevity Institute, the Advanced Cancer Research Institute, the Holistic Justice Institute and the Centre Mediterranéen Holistique de Vitalité et de Longévité Optimale in South Europe which organizes Optimal Vitality and Longevity mountain retreats during most Summers.

These workshops are fundraisers that will help us complete a book and a film-documentary on holistic oncology medicine.

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Top:  “To Life” (“L’ Chaim” in Hebrew)Professor Joubert, at the international integrative oncology convention (2016) in  San Diego toasting and “dégusting” (sipping) a small amount of red resveratrol-rich pinot wine with the conference President, Annie Brandt and her two assistants. “Wine is an appropriate article for mankind, both for the healthy body and for the ailing man.” Hippocrates 

Professor Joubert is also a French certified ECOCERT organic agricultural peasant-farmer and Holistic Mediterranean Diet Chef & wine master, in this capacity, he will prepare one Med-Diet Longevity dish and demonstrate how to pair wine with food as well as how to sip wine in a way that will enhance both wellbeing and neurogenesis

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“Medicine is a collection of uncertain prescriptions, the results of which taken collectively, are more fatal than useful to mankind. Water, air and cleanliness are the chief articles in my pharmacopeia”. Napoleon Bonaparte  To which Ben  Franklin, the Spiritual Father of the U.S. of A replied:  “The best of all medicines is resting and fasting”. Thus, these two giants agree on therapeutic siestas….(napping). Today, one of the central public issues is  to incorporate this piece of advise within the legally enforceable health Code. Which would mean that all employers, including the Govenment and its military, FDA and judicial branches, would need to install meditation and siesta equipment and allow a good two hours  for lunch breaks. 

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The Difference between a Conventional Check-up versus a Holistic Tune-up.

“Conventional Doctors are trained less to understand the conditions of health than to diagnose the symptoms of diseases. That’s why a 5 to 10 minutes doctor’s visit is sufficient. The Check-up visit mainly consists in identifying symptoms and finding a corresponding drug and-or surgical procedure to supress the identified symptoms.  On the other hand, a Holisically trained Health Professional is trained to identify the immediate and structural causes of diseases. Thereafter, the holistic healer will both guide and teach the patient to become “whole” again, to restore the body’s main homeostasis and repair mechanisms, at which point both the healer and the healee, as a team, can activate a customized (personalized) “tune-up” Protocol that will favorably modulate the mal-being and-or illness condition at hand.”  (H.M. Institute)

Workshop details

Scheduling: Pending

Location: Pending

Duration: Each Session is 8 hours.

Break-time: One hour for Leisure in between the 8 hours long Seminar. (Please bring your own lunch and-or snacks)

Content: All supported with Power Point Presentation and sometimes Video presentations

Price: To be fixed.

These funds will help to complete a documentary on holistic oncology.

Pre-registration required:

For Info and Registration, please contact info@happinessmedicine.com

goji
Top: Tibetan Mountain Goji Berries, a favorite super fruit  among supercentenarian Chinese Taoists and Tibetan Buddhists. Its polysaccharides  have many benefits including by enhancing:  “… neurogenesis in the hippocampus and subventricular zone, improving learning and memory abilities”(Source)
“Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.The enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being without distinction of race, religion, political belief, economic or social condition”.   (World Health Organization’s Constitution)

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Top: Ylang Ylang flower, from which is distilled one of the best aromatherapy essential oils

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Top: Rosemary, one of the Mediterranean plants that is abundant in both the Mediterranean longevity valleys and in centenarians’ guts

Workshop on Hormonal and neurotransmitter boosting and balancing as tools to develop more "joie de vivre" (enjoyment of Life). Click picture for details.

Top: red hot peppers, a great way to boost endorphins, immune function and metabolic pathways

For those interested in Holistic Retreat Updates & Continuing Education & Workshops from H.M. Institute

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“The young physician starts life with 20 drugs for each disease, and the old physician ends life with one drug for 20 diseases.”  (William Osler)  William Osler was a highly respected physician, professor and writer who authored “The Principles and Practice of Medicine” in 1892, which served as the standard clinical medicine text for 40 years. Later on in his life he wrote that one of the most crippling teachings in Medical schools is this “one pill for an ill” principle.

GifYogaBalance

“The art of medicine consists in amusing the patient while Nature cures the disease.”  Voltaire. One of 18th century Voltaire’s lessons to heal and be happy is to “cultivate one’s garden” (cf in his book Condide), that which can be translated to mean the cultivation of the low-key attitude of being joyfully humble and humbly joyful with an uplifting sense of purpose, awe and gratitude holistically expressed in the “now and here”, what is called in France “la joie de vivre”. 

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