Arthritis Diseases Research

RHEUMATOID ARTHRITIS

Rheumatoid arthritis (RA) is an autoimmune disease that causes pain, swelling, stiffness and loss of function in the joints. Unlike osteoarthritis, the common arthritis that develops from wear and tear on joints and usually develops as people age, RA can affect the young and old in general and in particular those who lack sunlight (Source). The disease can cause enormous suffering, it may attack the eyes, mouth and lungs as well as joints (Source). According to the National Institutes of Health, there’s no known cause for RA and treatments include steroids and other drugs that can have serious side effects. Yet, Lancet show decades ago plant-based diet was one of the therapeutic keys. Source See also a New York Times article (Source). Quercetin, Oregano and dental hygiene are also important…To read more, click here..

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“… Vitamin D deficiency has been implicated in the pathogenesis of autoimmune diseases, such as diabetes mellitus type 1 and multiple sclerosis. Reduced vitamin D intake has been linked to increased susceptibility to the development of rheumatoid arthritis (RA) and vitamin D deficiency has been found to be associated with disease activity in patients with RA (…) CONCLUSION: It appears that vitamin D deficiency is highly prevalent in patients with RA, and that vitamin D deficiency may be linked to disease severity in RA. As vitamin D deficiency has been linked to diffuse musculoskeletal pain, these results have therapeutic implications. Vitamin D supplementation may be needed both for the prevention of osteoporosis as well as for pain relief in patients with RA”. Ther Adv Endocrinol Metab. 2012 Dec;3(6):181-7. Vitamin D and rheumatoid arthritis. Kostoglou-Athanassiou I, Athanassiou P, Lyraki A, Raftakis I, Antoniadis C. Source Department of Endocrinology, Red Cross Hospital, 7 Korinthias Street, 115 26 Athens, Greece. Source (ie, mega dosages of vitamin D, not always appropriate, sunlight much better, source).

 

HEAT SHOCK PROTEINS, OREGANO AND RHEUMATOID ARTHRITIS.

The ability of the body to tolerate wear and tear before it enters into an inflammatory auto-immune state of accelerated tissue damage is of the utmost importance to preserving health.  An emerging body of science shows that certain T cells act to regulate tolerance to high stress by activating a natural anti-inflammatory defense system referred to as heat shock proteins (HSP).  One’s ability to activate HSP is associated with longevity. It’s action mechanism is connected to gene signaling that activate HSP.    The primary traditional use of oregano oil is as a pain and germ killer, with documented anti-bacterial, anti-fungal, and anti-parasitic activity. Carvacrol Induces Heat Shock Protein 60. Source  Heat-shock proteins, especially Hsp70 are involved in binding antigens and presenting them to the immune system (Source), including binding protein fragments from dead malignant cells and presenting them to the immune system.

 

Top: Oregano, a medicinal plant that grows wild all over the Pyrenean center thanks to which we may be able to offer en masse this herb to the Holwerrc’s clients.

“OBJECTIVE: Stress proteins, such as members of the heat-shock protein (HSP) family, are up-regulated by cells in inflamed tissue and can be viewed functionally as “biomarkers” for the immune system to monitor inflammation. Exogenous administration of stress proteins has induced immunoregulation in various models of inflammation and has also been shown to be effective in clinical trials in humans. This study was undertaken to test the hypothesis that boosting of endogenous HSP expression can restore effective immunoregulation through T cells specific for stress proteins. METHODS: Stress protein expression was manipulated in vivo and in vitro with a food component (carvacrol), and immune recognition of stress proteins was studied. RESULTS: Carvacrol, a major compound in the oil of many Origanum species, had a notable capacity to coinduce cellular Hsp70 expression in vitro and, upon intragastric administration, in Peyer’s patches of mice in vivo. As a consequence, carvacrol specifically promoted T cell recognition of endogenous Hsp70, as demonstrated in vitro by the activation of an Hsp70-specific T cell hybridoma and in vivo by amplified T cell responses to Hsp70. Carvacrol administration also increased the number of CD4+CD25+FoxP3+ T cells, systemically in the spleen and locally in the joint, and almost completely suppressed proteoglycan-induced experimental arthritis. Furthermore, protection against arthritis could be transferred with T cells isolated from carvacrol-fed mice. CONCLUSION: These findings illustrate that a food component can boost protective T cell responses to a self stress protein and down-regulate inflammatory disease, i.e., that the immune system can respond to diet.”Arthritis Rheum. 2010 Apr;62(4):1026-35. doi: 10.1002/art.27344. A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis. Wieten L, van der Zee R, Spiering R, Wagenaar-Hilbers J, van Kooten P, Broere F, van Eden W. Source Institute of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands.

 

Anecdotally, cherry juice has been used as a treatment for gout-related pain for decades. Though sample sizes are small, studies are also revealing that this juice might help with other types of joint pain and inflammation as well, including that caused by rheumatoid arthritis. Tart cherries have higher levels of anthocyanin, a phytonutrient and antioxidant, than sweet cherries and other fruits, making them power berries to reduce inflammation and pain, improve recovery time after strenuous activity.

RHEUMATOID ARTHRITIS AND PLANT BASED DIET

“Fasting is an effective treatment for rheumatoid arthritis, but most patients relapse on reintroduction of food. The effect of fasting followed by one year of a vegetarian diet was assessed in a randomised, single-blind controlled trial. 27 patients were allocated to a four-week stay at a health farm. After an initial 7-10 day subtotal fast, they were put on an individually adjusted gluten-free vegan diet for 3.5 months. The food was then gradually changed to a lactovegetarian diet for the remainder of the study. A control group of 26 patients stayed for four weeks at a convalescent home, but ate an ordinary diet throughout the whole study period. After four weeks at the health farm the diet group showed a significant improvement in number of tender joints, Ritchie’s articular index, number of swollen joints, pain score, duration of morning stiffness, grip strength, erythrocyte sedimentation rate, C-reactive protein, white blood cell count, and a health assessment questionnaire score. In the control group, only pain score improved score. In the control group, only pain score improved significantly. The benefits in the diet group were still present after one year, and evaluation of the whole course showed significant advantages for the diet group in all measured indices. This dietary regimen seems to be a useful supplement to conventional medical treatment of rheumatoid arthritis.” Lancet. 1991 Oct 12;338(8772):899-902. Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Kjeldsen-Kragh J, Haugen M, Borchgrevink CF, Laerum E, Eek M, Mowinkel P, Hovi K, Førre O. Source Department of General Practice, University of Oslo, Norway. Source

 

 

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