Cardiovascular Disease Research


Cardiac pain: It remains quite difficult to timely detect any symptoms of the problem until atheromatous disease is very advanced.

Video from the American cardiology society on how coronaries get occluded

A picture of plaque build-up made from animal cholesterol, milk calcium, macrophages and other element, all of which tend to swell, at which point the platelet precipitate a clot.

Atheromata continue to be the primary underlying basis for disability and death. According to United States data, 2004, for about 65% of men and 47% of women, the first symptom of cardiovascular disease is myocardial infarction (heart attack) or sudden death (death within one hour of symptom onset.)




“Heart diseases is a toothless paper tiger that should never never exist”. Dr Esselstyn

Our genetic make-up, shaped through millions of years of evolution and connected to that of the great apes, determines our nutritional and activity needs. Although the human genome has remained primarily unchanged since the agricultural revolution 10,000 years ago, our diet and lifestyle have become progressively more divergent from those of our ancient ancestors. Accumulating evidence suggests that this mismatch between our modern diet and lifestyle and our Paleolithic genome is playing a substantial role in the ongoing epidemics of obesity, hypertension, diabetes, and atherosclerotic cardiovascular disease. Until 500 generations ago, all humans consumed only wild and unprocessed food foraged from their environment, much of which was raw and plant-based. These circumstances provided a diet in healthy protein, polyunsaturated fats (especially omega-3 [omega-3] fatty acids), monounsaturated fats, fiber, vitamins, minerals, antioxidants, and other beneficial phytochemicals, all of which constitute a form of caloric restriction in terms of today’s caloric intake.(See this study on caloric restriction, intermittent fast and strokes and heart disease). Historical and anthropological studies show our ancesters to be healthy, fit, and largely free of the degenerative cardiovascular diseases common in modern societies. Many studies show that converting to an organic, living plant-based diet with proper exericses and sunlight can not only avoid most chronic diseases, but also partially treat them….To read more, please click here….




In order to determine a satisfactory course of remedial action, it is necessary to know Alzheimers’ etiology (causes). In Alzheimer’s disease, a peptide called amyloid beta forms aggregates (oligomers), which accumulate in the brain and form deposits known as amyloid plaques. (Source) Inflammation and oxidative damage are also associated with the progession of Alzheimer’s disease. (Source). Recent research at the Brown University in Rhode Island and elsewhere (Source), suggests that the development of Alzheimers is connected to lifestyle assaults, in particular to that which causes diabetes, the lack of insulin sensitivity. To read more, click here….


Top: Electro-medicine and Alzheimer’s disease: “The pharmacological treatment of Alzheimer’s disease (AD) is often limited and accompanied by drug side effects. Thus alternative therapeutic strategies such as non-invasive brain stimulation are needed. Few studies have demonstrated that transcranial direct current stimulation (tDCS), a method of neuromodulation with consecutive robust excitability changes within the stimulated cortex area, is beneficial in AD. There is also evidence that tDCS enhances memory function in cognitive rehabilitation in depressive patients, Parkinson’s disease, and stroke. tDCS improves working and visual recognition memory in humans and object-recognition learning in the elderly. AD’s neurobiological mechanisms comprise changes in neuronal activity and the cerebral blood flow (CBF) caused by altered microvasculature, synaptic dysregulation from ß-amyloid peptide accumulation, altered neuromodulation via degenerated modulatory amine transmitter systems, altered brain oscillations, and changes in network connectivity. tDCS alters (i) neuronal activity and (ii) human CBF, (iii) has synaptic and non-synaptic after-effects (iv), can modify neurotransmitters polarity-dependently, (v) and alter oscillatory brain activity and (vi) functional connectivity patterns in the brain. It thus is reasonable to use tDCS as a therapeutic instrument in AD as it improves cognitive function in manner based on a disease mechanism. Moreover, it could prove valuable in other types of dementia. Future large-scale clinical and mechanism-oriented studies may enable us to identify its therapeutic validity in other types of demential disorders” .Front Psychiatry. 2012;3:48. doi: 10.3389/fpsyt.2012.00048. Epub 2012 May 15. Action mechanisms of transcranial direct current stimulation in Alzheimer’s disease and memory loss. Hansen N. Source Department of Neurophysiology, Ruhr University Bochum Bochum, Germany. (Source). There are 13 studies in pub med on tDCS and Alzheimier like conditions (source) and source a. Clinical trial ongoing. For Israel research, see source. For technique modalities, source. This technique is also good for pain source and source b and source c



Rheumatoid arthritis (RA) is an autoimmune disease that causes pain, swelling, stiffness and loss of function in the joints. Unlike osteoarthritis, the common arthritis that develops from wear and tear on joints and usually develops as people age, RA can affect the young and old in general and in particular those who lack sunlight (Source). The disease can cause enormous suffering, it may attack the eyes, mouth and lungs as well as joints (Source). According to the National Institutes of Health, there’s no known cause for RA and treatments include steroids and other drugs that can have serious side effects. Yet, Lancet show decades ago plant-based diet was one of the therapeutic keys. Source See also a New York Times article (Source). Quercetin, Oregano and dental hygiene are also important…To read more, click here..




“… Vitamin D deficiency has been implicated in the pathogenesis of autoimmune diseases, such as diabetes mellitus type 1 and multiple sclerosis. Reduced vitamin D intake has been linked to increased susceptibility to the development of rheumatoid arthritis (RA) and vitamin D deficiency has been found to be associated with disease activity in patients with RA (…) CONCLUSION: It appears that vitamin D deficiency is highly prevalent in patients with RA, and that vitamin D deficiency may be linked to disease severity in RA. As vitamin D deficiency has been linked to diffuse musculoskeletal pain, these results have therapeutic implications. Vitamin D supplementation may be needed both for the prevention of osteoporosis as well as for pain relief in patients with RA”. Ther Adv Endocrinol Metab. 2012 Dec;3(6):181-7. Vitamin D and rheumatoid arthritis. Kostoglou-Athanassiou I, Athanassiou P, Lyraki A, Raftakis I, Antoniadis C. Source Department of Endocrinology, Red Cross Hospital, 7 Korinthias Street, 115 26 Athens, Greece. Source (ie, mega dosages of vitamin D, not always appropriate, sunlight much better, source).



The ability of the body to tolerate wear and tear before it enters into an inflammatory auto-immune state of accelerated tissue damage is of the utmost importance to preserving health.  An emerging body of science shows that certain T cells act to regulate tolerance to high stress by activating a natural anti-inflammatory defense system referred to as heat shock proteins (HSP).  One’s ability to activate HSP is associated with longevity. It’s action mechanism is connected to gene signaling that activate HSP.    The primary traditional use of oregano oil is as a pain and germ killer, with documented anti-bacterial, anti-fungal, and anti-parasitic activity. Carvacrol Induces Heat Shock Protein 60. Source  Heat-shock proteins, especially Hsp70 are involved in binding antigens and presenting them to the immune system (Source), including binding protein fragments from dead malignant cells and presenting them to the immune system.


Top: Oregano, a medicinal plant that grows wild all over the Pyrenean center thanks to which we may be able to offer en masse this herb to the Holwerrc’s clients.

“OBJECTIVE: Stress proteins, such as members of the heat-shock protein (HSP) family, are up-regulated by cells in inflamed tissue and can be viewed functionally as “biomarkers” for the immune system to monitor inflammation. Exogenous administration of stress proteins has induced immunoregulation in various models of inflammation and has also been shown to be effective in clinical trials in humans. This study was undertaken to test the hypothesis that boosting of endogenous HSP expression can restore effective immunoregulation through T cells specific for stress proteins. METHODS: Stress protein expression was manipulated in vivo and in vitro with a food component (carvacrol), and immune recognition of stress proteins was studied. RESULTS: Carvacrol, a major compound in the oil of many Origanum species, had a notable capacity to coinduce cellular Hsp70 expression in vitro and, upon intragastric administration, in Peyer’s patches of mice in vivo. As a consequence, carvacrol specifically promoted T cell recognition of endogenous Hsp70, as demonstrated in vitro by the activation of an Hsp70-specific T cell hybridoma and in vivo by amplified T cell responses to Hsp70. Carvacrol administration also increased the number of CD4+CD25+FoxP3+ T cells, systemically in the spleen and locally in the joint, and almost completely suppressed proteoglycan-induced experimental arthritis. Furthermore, protection against arthritis could be transferred with T cells isolated from carvacrol-fed mice. CONCLUSION: These findings illustrate that a food component can boost protective T cell responses to a self stress protein and down-regulate inflammatory disease, i.e., that the immune system can respond to diet.”Arthritis Rheum. 2010 Apr;62(4):1026-35. doi: 10.1002/art.27344. A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis. Wieten L, van der Zee R, Spiering R, Wagenaar-Hilbers J, van Kooten P, Broere F, van Eden W. Source Institute of Infectious Diseases and Immunology, Utrecht University, 3584 CL Utrecht, The Netherlands.


Anecdotally, cherry juice has been used as a treatment for gout-related pain for decades. Though sample sizes are small, studies are also revealing that this juice might help with other types of joint pain and inflammation as well, including that caused by rheumatoid arthritis. Tart cherries have higher levels of anthocyanin, a phytonutrient and antioxidant, than sweet cherries and other fruits, making them power berries to reduce inflammation and pain, improve recovery time after strenuous activity.


“Fasting is an effective treatment for rheumatoid arthritis, but most patients relapse on reintroduction of food. The effect of fasting followed by one year of a vegetarian diet was assessed in a randomised, single-blind controlled trial. 27 patients were allocated to a four-week stay at a health farm. After an initial 7-10 day subtotal fast, they were put on an individually adjusted gluten-free vegan diet for 3.5 months. The food was then gradually changed to a lactovegetarian diet for the remainder of the study. A control group of 26 patients stayed for four weeks at a convalescent home, but ate an ordinary diet throughout the whole study period. After four weeks at the health farm the diet group showed a significant improvement in number of tender joints, Ritchie’s articular index, number of swollen joints, pain score, duration of morning stiffness, grip strength, erythrocyte sedimentation rate, C-reactive protein, white blood cell count, and a health assessment questionnaire score. In the control group, only pain score improved score. In the control group, only pain score improved significantly. The benefits in the diet group were still present after one year, and evaluation of the whole course showed significant advantages for the diet group in all measured indices. This dietary regimen seems to be a useful supplement to conventional medical treatment of rheumatoid arthritis.” Lancet. 1991 Oct 12;338(8772):899-902. Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Kjeldsen-Kragh J, Haugen M, Borchgrevink CF, Laerum E, Eek M, Mowinkel P, Hovi K, Førre O. Source Department of General Practice, University of Oslo, Norway. Source



Asthma is a chronic disease of the airways, most commonly driven by immuno-inflammatory responses to ubiquitous airborne antigens. Epidemiological studies have shown that disease is initiated early in life when the immune and respiratory systems are functionally immature and less able to maintain homeostasis in the face of continuous antigen challenge. In other words, the airway hyper-responsiveness measures the air passages’ tendency to constrict, leading to breathing difficulty.
Rresearchers found that
hyper-responsiveness was twice as high in patients with vitamin D levels below 30 nanograms per milliliter, lung function was worse, and the body responded more poorly to steroid therapy. Worse, the bodies of people with low vitamin D levels produced more of the immune system signaling chemical TNF-alpha, which increases inflammation. Consistent with many studies, that overweight or obese participants are were significantly more likely to suffer from vitamin D deficiency because fat sequesters vitamin D in the body, thus people with more body fat need higher levels of the vitamin. Children are also vulnerable and, without adequate vitamin D, are prone to become asthmatics. (Source) Asthma treatment can also in turn increases the risk of vitamin D deficiency.

“It is … known that glucocorticoids [steroids used in asthma treatment] increase the destruction of vitamin D, thus making patients with asthma at higher risk for vitamin D deficiency, which in turn decreases lung function and makes their disease worse,” said Michael F. Holick, of Boston University.


“RATIONALE: Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma. OBJECTIVES: To determine the effect of vitamin D levels on phenotype and GC response in asthma. (…) CONCLUSIONS: In asthma, reduced vitamin D levels are associated with impaired lung function, increased AHR, and reduced GC response, suggesting that supplementation of vitamin D levels in patients with asthma may improve multiple parameters of asthma severity and treatment response…” Am J Respir Crit Care Med. 2010 Apr 1;181(7):699-704. doi: 10.1164/rccm.200911-1710OC. Epub 2010 Jan 14. Vitamin D levels, lung function, and steroid response in adult asthma. Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Source Department of Medicine, University of Colorado, Denver, Colorado, USA. Source


Top: purple passion fruit, whose extract may be safely offered to asthmatic patients as an alternative treatment option to reduce clinical symptoms. (Source)

“Asthma, affecting as many as 400 million individuals worldwide, is one of the most prevalent chronic health condition in the United States. With an increasing number of patients with asthma and the frequent inability of conventional lifestyle modification and therapy to effectively control the problem, nutritional and dietary therapies are being sought. This study was undertaken to investigate the efficacy of the purple passion fruit peel (PFP) extract, a novel mixture of bioflavonoids, on asthma symptoms. Patients with asthma were studied in a 4-week randomized, placebo-controlled, double-blind trial with oral administration of PFP extract (150 mg/d) or placebo pills. The effects of PFP extract were evaluated by assessing the clinical symptoms of asthma and spirometry tests. Most clinical symptoms of asthma of the PFP extract-treated group were moderated significantly compared to the baseline. The prevalence of wheeze, cough, as well as shortness of breath was reduced significantly in group treated with PFP extract (P < .05), whereas the placebo caused no significant improvement. Purple passion fruit peel extract supplementation resulted in a marked increase in forced vital capacity (P < .05) as placebo showed no effect. However, no significant improvement was observed in the forced expiratory volume at 1 second of those supplemented with PFP extract. No adverse effect was reported by any of study participants. The PFP extract may be safely offered to asthmatic subjects as an alternative treatment option to reduce clinical symptoms” .Nutr Res. 2008 Mar;28(3):166-71. doi: 10.1016/j.nutres.2008.01.003. Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma. Watson RR, Zibadi S, Rafatpanah H, Jabbari F, Ghasemi R, Ghafari J, Afrasiabi H, Foo LY, Faridhosseini R. Source Southwest Scientific Editing and Consulting L.L.C., Tucson, AZ 85749, USA.(Source)


Top: Probiotics, key for immune-regulation, proper digestion, inflammation control and asthma (Source)

“Increasing awareness of the role of intestinal commensal bacteria in the development and modulation of the immune system has led to great interest in the therapeutic potential of probiotics and other bacteria-based strategies for a range of immune-related disorders. Studies in animal models have identified strong immunomodulatory effects of many nonpathogenic bacteria and provided evidence that intestinal microbes can activate a common mucosal immune response and, thus, influence sites distant to the intestine, including the respiratory tract. Respiratory effects of probiotics in animal models have included attenuating allergic airway responses and protecting against respiratory pathogens. Dendritic cells appear central to directing the beneficial immune response to probiotic bacteria and in translating microbial signals from the innate to the adaptive immune system, whereas regulatory T cells are emerging as potentially key effectors of probiotic-mediated responses, particularly in the reduction of allergic inflammation. Despite progress in basic research, clinical trials of probiotics in allergy/asthma and respiratory infection have been highly variable at best, leading to an undermining of confidence in this potential therapeutic strategy. It is clear that there is still much to learn regarding the determinants of the diverse immune responses elicited by different bacterial strains. A deeper knowledge of the interactions between administered probiotics and the existing microbiota, together with an understanding of how the dialogue between microbes and the innate immune system is translated into beneficial/protective responses, will be required before we can achieve clinically effective bacteria-based strategies that maintain and promote respiratory health”. Chest. 2011 Apr;139(4):901-8. doi: 10.1378/chest.10-1861. Probiotics and lung diseases. Forsythe P. Source Brain-Body Institute and Department of Medicine, McMaster University, Hamilton, ON, Canada. Source


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