On and off telomerase switch for aging cells discovered

Scientists at the Salk Institute have discovered an on-and-off “switch” in aging cells. In a  study published September 19 2014, in the journal Genes and Development, scientists at the Salk Institute have discovered that telomerase, even when present, can be turned off.
“Previous studies had suggested that once assembled, telomerase is available whenever it is needed,” says senior author Vicki Lundblad, professor and holder of Salk’s Ralph S. and Becky O’Connor Chair. “We were surprised to discover instead that telomerase has what is in essence an ‘off’ switch, whereby it disassembles.”
Understanding how this “off” switch can be manipulated–thereby slowing down the telomere shortening process–could lead to treatments for diseases of aging (for example, regenerating vital organs later in life).
This study showed that immediately after the full telomerase complex has been assembled, it rapidly disassembles to form an inactive “disassembly” complex, essentially flipping the switch into the “off” position. This disassembly pathway may provide a means of keeping telomerase at exceptionally low levels inside the cell, which can be useful to minimize the cancer risks.

 

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Journal Reference:
T. M. Tucey, V. Lundblad. Regulated assembly and disassembly of the yeast telomerase quaternary complex. Genes & Development, 2014.
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Professor Joubert teaches how to extend a healthy cancer-free Lifespan to 122 years thanks to safe, efficient and cost friendly breakthrough protocols. Working on a documentary and book that redefines Medicine in light of new discoveries, ancient wisdoms, innovative research and holistic science, he can be nonetheless available to coach patients back to homeostasis, wellbeing & Joie de Vivre. On occasion, Pr. Joubert can also coach health professionals to better protect their holistic practice when they must deviate from outdated and-or irrational mainstream “standards of care” in order to genuinely serve their patients, evidence-strong Science and internationally recognized human rights. For details, see the links called “Contact” and “Mission” (under the “About” link).

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