Serum amyloid P component (SAP) binds to all amyloid fibrils including those in the plaques and tangles of Alzheimer patients. To investigate whether the plasma SAP concentration correlated to cognitive impairment, this study referenced below measured SAP levels in blood samples from 41 centenarians and compared these to the cognitive performance evaluated by Mini Mental State Examination (MMSE).
The results were as followed: there was a significantly (p < 0.001) increased SAP concentration (48.3+/-16.9 microg/ml; mean +/- SD) in the centenarians compared to gender-matched controls (32.8+/-11.4 microg/ml). Six severely demented centenarians had an even higher SAP concentration (60.2 microg/ml), while the subgroup of cognitive intact centenarians (MMSE score >24) showed a normal SAP concentration (38.4+/-9.3 microg/ml). The study’s authors assessed that:
“… the centenarians with impaired cognitive performance had significantly increased plasma concentrations of SAP, while the values for cognitive intact centenarians were within the normal range.” (1)
As a consequence thereto, serum amyloid P component (SAP) can be used as a mental impairement marker for those elderly who are suspected on suffering from amyloid fibrils associated to Alzheimer’s Disease.
(1). Dement Geriatr Cogn Disord. 1998 May-Jun;9(3):126-9. “Increased plasma concentration of serum amyloid P component in centenarians with impaired cognitive performance”. By: Nybo M1, Olsen H, Jeune B, Andersen-Ranberg K, Holm Nielsen E, Svehag SE.
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