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Senescent Cells & Holistic Medicine

Senescent cell are cells  that scientists call zombie cells because they refuse to die. Dysfunctional, they have ceased to divide and just linger in tissues in a state of inflammatory “decomposition”. Metabolically active, these cells are normally useful and get eliminated by the immune system or destroyed in the form of programmed cell death. If they don’t, if they accumulate in the body, they accelerate the aging process by harming surrounding cells over time. Senescent cells are removed from the body by a robust immune system.  The immune cells that participate in the clearance of senescent cells are natural killer cells,

Posted in Longevity Pathways

Longevity is connected to Attitude and Personality

Like humans, animals have distinct personalities. Our close evolutionary cousins chimpanzees even display the same five major personality traits that we do – extraversion, neuroticism, conscientiousness, openness, and agreeableness – as well as a distinct trait, for dominance. “Using data from 538 captive chimpanzees (Pan troglodytes) we tested whether any of the dimensions of chimpanzee personality – agreeableness, conscientiousness, dominance, extraversion, neuroticism, and openness – were associated with longevity, an attribute of slow life history strategies that is especially important in primates given their relatively long lives. We found that higher agreeableness was related to longevity in males, with weaker

Posted in Longevity Pathways

The Major Mechanisms of Aging

In this blog-article, I will review some of the central hallmarks or mechanims of aging,  (Section A)  And in the second section, I will examine subsidiary mechanisms of aging (Section B). Section A The Central Hallmarks of Aging Hallmarks of aging are comprised of multiple inter-related mechanisms that characterize the  process of aging. So far, there is an international scientific consensus that these central hallmarks are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.” (1) Aging hallmarks can also be defined in terms of how well

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Healthy Centenarians and Thirty years Old Healthy Individuals Share Similar Diverse Microbiota

In a recent microbiota study conducted in humans, researchers have shown a significant correlation between healthy aging and a healthy gut as compared to younger microbiota. In this blog-article, i will first examine the substance of these findings  (Section A)  and then compare them with other former studies from which this one derived.(Section B). Thereafter, I will discuss a  few implications that this and other studies inspire. (Section C). Section A Microbiota & Gut Diversity This microbiota longevity Study was published last  September 2017, in the journal mSphere (1). The Chinese researchers from this study found was a significant correlation between the gut

Posted in Longevity Pathways

DNA repair mechanisms recognized by a 2015 Nobel Prize in Chemistry

The Royal Swedish Academy of Sciences  awarded the 2015 Nobel Prize in Chemistry jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar for mechanistic studies of DNA repair. (1) The honored research recognized three DNA repair mechanisms that was recognized is relevant for a better understanding of the aging process and malignancy. SIGNIFICANCE OF INNOVATIVE DNA REPAIR RESEARCH The DNA (1)  is often damaged by industrial pollutants, conventional therapies like chemo and radiation therapy,  ultraviolet light from the sun and the like. To make matters worse, the human genome of each cell undergoes thousands of spontaneous changes each day. And DNA

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Super-centenarians, amyloidosis and the next frontier to human life span

Because most super-centenarians die from one of the different forms of amyloidosis, (1) Optimal Longevity Institute’s research team delves into deep research in order to better understand the underlying amyloidosis mechanisms and figure out ways to better control and reverse it. This article is based on extensive research and can be acquired for a fee. Copyright (c) 2016. Optimal Longevity Institute. All rights reserved. Disclaimer: Nothing in this educational blog should be construed as providing formal medical advise.

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Telomerase Gene Therapy Activates Longevity

Researchers at the Spanish National Cancer Research Center (CNIO) (1) have published a study in EMBO Mol Med. Journal  (2) that shows rodent lifespan to be extended from 13 percent  up to 24 percent in one “telomerase gene” treatment without spurring cancer or other metabolic dysfunctions. In this realm, the Spanish Scientists have thus tested the effects of this telomerase gene therapy on telomeres, (3)  in adult (1 year of age) and old (2 years of age) mice by treating 1- and 2-year old mice with an adeno associated virus (AAV) of wide tropism expressing mouse TERT.  (4) The results

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The “SAP”, an “Impaired cognitive performance” Marker for Centenarians

Serum amyloid P component (SAP) binds to all amyloid fibrils including those in the plaques and tangles of Alzheimer patients. To investigate whether the plasma SAP concentration correlated to cognitive impairment, this study referenced below measured SAP levels in blood samples from 41 centenarians and compared these to the cognitive performance evaluated by Mini Mental State Examination (MMSE). The results were as followed: there was a significantly (p < 0.001) increased SAP concentration (48.3+/-16.9 microg/ml; mean +/- SD) in the centenarians compared to gender-matched controls (32.8+/-11.4 microg/ml). Six severely demented centenarians had an even higher SAP concentration (60.2 microg/ml), while the

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Metformin Anti-Aging Study on Humans has been approved by the FDA

Just this last November 2015, the FDA has approved a large-scale human study to see if metformin, the common diabetes drug, can protect against the multiple diseases of aging. “Scientists believe the common diabetes drug metformin could hold the secret of long life and want to start a groundbreaking human trial in 2016. The world’s first anti-ageing drug will be tested on humans next year in trials which could see diseases like Alzheimer’s and Parkinson’s consigned to distant memory. Scientists now believe that it is possible to actually stop people growing old as quickly and help them live in good

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Activating longevity genes is never too late: new findings for the elderly.

In an advanced experimenation on the elderly,  a scientific team from the the University of California, Riverside examined a few years back  how gene activity changes when an elderly mouse eats less. By cutting calories for only four weeksm  old mice were able to  mimick most of the genetic effects of a lifetime of calorific restriction. The supporting evidence showed that over half the changes that usually occur with aging were absent from mice that were given 44% fewer calories. Since this study’s publication, the Institue’s team has not seen any evidence showing the contrary to what this study confirmed.

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